Kenneth W. Kinzler
University of Wisconsin-Madison
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Publication
Featured researches published by Kenneth W. Kinzler.
Archive | 2001
Prasad V. Jallepalli; Irene Waizenegger; Fred Bunz; Sabine Langer; Michael R. Speicher; Jan-Michael Peters; Kenneth W. Kinzler; Bert Vogelstein; Christoph Lengauer
Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian cells are therefore of great interest. Here we show that human cells without an hSecurin gene lose chromosomes at a high frequency. This loss was linked to abnormal anaphases during which cells underwent repetitive unsuccessful attempts to segregate their chromosomes. The abnormal mitoses were associated with biochemical defects in the activation of separin, the sister-separating protease, rendering it unable to cleave the cohesin subunit Scc1 efficiently. These results illuminate the function of mammalian securin and show that it is essential for the maintenance of euploidy.
Genomics | 1993
Cindy Luongo; Karen A. Gould; Li Kuo Su; Kenneth W. Kinzler; Bert Vogelstein; William F. Dietrich; Eric S. Lander; Amy R. Moser
Archive | 2003
Brad St. Croix; Kenneth W. Kinzler; Bert Vogelstein
Archive | 2001
Victor Velculescu; Andrew Sparks; Kenneth W. Kinzler; Bert Vogelstein
Archive | 1994
Bert Vogelstein; Kenneth W. Kinzler
Archive | 2001
Jian Yu; Kenneth W. Kinzler; Bert Vogelstein
Archive | 2001
Nickolas Papadopoulos; Hai Yan; Bert Vogelstein; Kenneth W. Kinzler
Archive | 2002
Bert Vogelstein; Kenneth W. Kinzler; Le-ming Shih
Archive | 1997
Albert de la Chapelle; Bert Vogelstein; Kenneth W. Kinzler
Archive | 1998
Albert de la Chapelle; Bert Vogelstein; Kenneth W. Kinzler
