Bettina M. Frost

An Experimental Model for Evaluation of Antifungal Agents in a Trichophyton mentagrophytes Infection of Guinea Pigs

A Trichophyton mentagrophytes infection of guinea pigs induced by an occlusive procedure is described. The method of evaluation permits comparison of efficacy of antifungal agents which are not tested simultaneously. Activity was demonstrated following topical application of clotrimazole, miconazole, tolnaftate or griseofulvin and oral administration of griseofulvin. Oral ketoconazole had little effect in this dermatophyte model.

Induced in vitro Resistance of Staphylococci to Streptomycin and Penicillin.

Summary 1. Under certain conditions strains of S. aureus develop resistance in vitro to streptomycin or to penicillin (G). 2. Greater variation occurs in the degree and rate at which resistance is acquired to penicillin than to streptomycin. 3. All of the streptomycin and penicillin-resistant strains studied showed some decrease in resistance upon transfer in broth free of the antibiotics. 4. Two of the penicillin-fast strains increased in resistance to streptomycin whereas the streptomycin-fast strains remained sensitive to penicillin. 5. Some streptomycin-fast staphylococcal strains show a change in pigment production and a reduction in the rate of carbohydrate fermentation.

In vitro and in vivo Activity of 3-(1-Methyl 1-5-Nitro-2 Imidazolylmethylideneamino)-2-OxazoIidinone against Pasteurella

Furazolidone was more active than 3-(1-methyl)-5-nitro-2-imidazolyl-methylideneamino)-2-oxazolidinone (MABN) against a series of 34 isolates of Pasteurella and 11 of Yersinia (forme