Mary E. Valiant

An Experimental Model for Evaluation of Antifungal Agents in a Trichophyton mentagrophytes Infection of Guinea Pigs

A Trichophyton mentagrophytes infection of guinea pigs induced by an occlusive procedure is described. The method of evaluation permits comparison of efficacy of antifungal agents which are not tested simultaneously. Activity was demonstrated following topical application of clotrimazole, miconazole, tolnaftate or griseofulvin and oral administration of griseofulvin. Oral ketoconazole had little effect in this dermatophyte model.

Binding of Novobiocin with Plasma Proteins

Summary 1. Fraction studies with plasma from a dog treated with novobiocin showed that novobiocin is extensively bound to plasma albumin. 2. In vitro experiments with crystalline bovine albumin showed that the binding is a reversible process.

In vitro and in vivo Activity of 3-(1-Methyl 1-5-Nitro-2 Imidazolylmethylideneamino)-2-OxazoIidinone against Pasteurella

Furazolidone was more active than 3-(1-methyl)-5-nitro-2-imidazolyl-methylideneamino)-2-oxazolidinone (MABN) against a series of 34 isolates of Pasteurella and 11 of Yersinia (forme