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Dive into the research topics where Bingjiang Zhou is active.

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Featured researches published by Bingjiang Zhou.


Nature Communications | 2014

A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation

Jiechao Ge; Minhuan Lan; Bingjiang Zhou; Weimin Liu; Liang Guo; Hui Wang; Qingyan Jia; Guangle Niu; Xing Huang; Hangyue Zhou; Xiang-Min Meng; Pengfei Wang; Chun-Sing Lee; Wenjun Zhang; Xiaodong Han

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of ~1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo- and pH-stability, and biocompatibility.


Journal of Organic Chemistry | 2013

Coumarin- and rhodamine-fused deep red fluorescent dyes: synthesis, photophysical properties, and bioimaging in vitro.

Jianhong Chen; Weimin Liu; Bingjiang Zhou; Guangle Niu; Hongyan Zhang; Jiasheng Wu; Ying Wang; Weigang Ju; Pengfei Wang

A series of deep red fluorescent dyes (CR1 to CR3) was developed via introduction of a coumarin moiety into the rhodamine molecular skeleton. The novel dyes possessed the individual advantages of coumarin and rhodamine derivatives, and the emission wavelength was extended to the deep red region (>650 nm) due to the extension of fused-ring conjugate structure simultaneously. To illustrate its value, we designed and conveniently synthesized a series of novel deep red bioimaging dyes (CR1E to CR3E) by esterification of CR1 to CR3, which could selectively stain mitochondria. They were superior to the MitoTrackers for mitochondrial staining in terms of large Stokes shift, excellent contrast for imaging, high photostability, and low cytotoxicity. Furthermore, the fluorescence of the coumarin moiety and rhodamine-like fluorophore could be switched like classical rhodamine. Thus, they could be used as an effective platform in constructing fluorescence sensors. Based on this fact, we constructed a novel ratiometric sensor (CR1S) for Hg(2+) with good selectivity that could be successfully applied to the imaging of Hg(2+) in living A549 cells. This design strategy is straightforward and adaptable to various deep red dyes and sensing platforms by simply introducing different fluorophores.


Advanced Healthcare Materials | 2016

Carbon Dots with Intrinsic Theranostic Properties for Bioimaging, Red‐Light‐Triggered Photodynamic/Photothermal Simultaneous Therapy In Vitro and In Vivo

Jiechao Ge; Qingyan Jia; Weimin Liu; Minhuan Lan; Bingjiang Zhou; Liang Guo; Hangyue Zhou; Hongyan Zhang; Ying Wang; Ying Gu; Xiang-Min Meng; Pengfei Wang

Cancer nanotheranostics combining therapeutic and imaging functions within a single nanoplatform are extremely important for nanomedicine. In this study, carbon dots (C-dots) with intrinsic theranostic properties are prepared by using polythiophene benzoic acid as carbon source. The obtained C-dots absorb light in the range of 400-700 nm and emit bright fluorescence in the red region (peaking from 640 to 680 nm at different excitations). More importantly, the obtained C-dots exhibit dual photodynamic and photothermal effects under 635 nm laser irradiation with a singlet oxygen ((1)O2) generating efficiency of 27% and high photothermal conversion efficiency of 36.2%. These unique properties enable C-dots to act as a red-light-triggered theranostic agent for imaging-guided photodynamic-photothermal simultaneous therapy in vitro and in vivo within the therapeutic window (600-1000 nm).


RSC Advances | 2013

A red fluorescent probe for thiols based on 3-hydroxyflavone and its application in living cell imaging

Song Chen; Peng Hou; Bingjiang Zhou; Xiangzhi Song; Jiasheng Wu; Hongyan Zhang; James W. Foley

A novel red (λmaxem = 632 nm) fluorescent probe based on 3-hydroxyflavone was designed and synthesized for thiol recognition with high sensitivity and excellent selectivity. Application of the probe for selective detection of intracellular thiols has been successfully demonstrated.


Nano Letters | 2014

Silicon Nanowire-Based Fluorescent Nanosensor for Complexed Cu2+ and its Bioapplications

Rong Miao; Lixuan Mu; Hongyan Zhang; Guangwei She; Bingjiang Zhou; Haitao Xu; Pengfei Wang; Wensheng Shi

A silicon nanowires (SiNWs)-based fluorescent sensor for complexed Cu(2+) was realized. High sensitivity and selectivity of the present sensor facilitate its bioapplications. The sensor was successfully used to detect the Cu(2+) in liver extract. Meanwhile, real-time and in situ monitoring of Cu(2+) released from apoptotic HeLa cell was performed using the as-prepared SiNW arrays-based sensor. These results indicate that the present SiNWs-based sensor would be of potential applications in revealing the physiological and pathological roles of Cu(2+).


Biosensors and Bioelectronics | 2015

Imaging of nucleolar RNA in living cells using a highly photostable deep-red fluorescent probe.

Bingjiang Zhou; Weimin Liu; Hongyan Zhang; Jiasheng Wu; Sha Liu; Haitao Xu; Pengfei Wang

A new crescent-shape fluorescent probe (named here as CP) that selectively stains RNA in nucleoli of living cells is prepared. CP shows a deep-red emission (658 nm) and a large Stokes shift because of the introduction of rigid-conjugated coumarin moiety into the molecular structure. Cell imaging experiments indicate that CP can rapidly stain nucleoli in living cells by binding with nucleolar RNA, showing performance superior to commercially available nucleoli dye SYTO RNASelect in terms of high photostability and selectivity. More significantly, these excellent properties together with low cytotoxicity enable CP to monitor nucleolar RNA changes during mitosis, and after treating with anti-cancer drugs cisplatin, actinomycin D and α-amanitin. Thus, CP could be a potential tool for real-time, long-term visualization of the dynamic changes for nucleolar RNA and evaluation of the therapeutic effect for anti-cancer drugs that targeted RNA polymerase I (Pol I).


Biosensors and Bioelectronics | 2013

Ultrasensitive and selective gold film-based detection of mercury (II) in tap water using a laser scanning confocal imaging-surface plasmon resonance system in real time

Hongyan Zhang; Liquan Yang; Bingjiang Zhou; Weimin Liu; Jiechao Ge; Jiasheng Wu; Ying Wang; Pengfei Wang

An ultrasensitive and selective detection of mercury (II) was investigated using a laser scanning confocal imaging-surface plasmon resonance system (LSCI-SPR). The detection limit was as low as 0.01ng/ml for Hg(2+) ions in ultrapure and tap water based on a T-rich, single-stranded DNA (ssDNA)-modified gold film, which can be individually manipulated using specific T-Hg(2+)-T complex formation. The quenching intensity of the fluorescence images for rhodamine-labeled ssDNA fitted well with the changes in SPR. The changes varied with the Hg(2+) ion concentration, which is unaffected by the presence of other metal ions. The coefficients obtained for ultrapure and tap water were 0.99902 and 0.99512, respectively, for the linear part over a range of 0.01-100ng/ml. The results show that the double-effect sensor has potential for practical applications with ultra sensitivity and selectivity, especially in online or real-time monitoring of Hg(2+) ions pollution in tap water with the further improvement of portable LSCI-SPR instrument.


Journal of Organic Chemistry | 2015

Aminobenzofuran-Fused Rhodamine Dyes with Deep-Red to Near-Infrared Emission for Biological Applications

Guangle Niu; Weimin Liu; Jiasheng Wu; Bingjiang Zhou; Jianhong Chen; Hongyan Zhang; Jiechao Ge; Ying Wang; Haitao Xu; Pengfei Wang

Aminobenzofuran-fused rhodamine dyes (AFR dyes) containing an amino group were constructed by an efficient condensation based on 3-coumaranone derivatives. AFR dyes exhibited significantly improved properties, including deep-red and near-infrared emissions, a large Stokes shift, good photostability, and wide pH stability. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium assay experiments show that these AFR dyes are biocompatible for their low cytotoxicity to both A549 and HeLa cells. Cell imaging data reveal that AFR1, AFR1E, and AFR2 are mainly located in the mitochondria, while AFR3 is a lysosome tracker. As far as we know, NIR AFR3 is the longest fluorescent rhodamine derivative containing the amino group. These amino group-containing AFR dyes hold great potential in fluorogenic detection, biomolecule labeling, and cell imaging.


ACS Applied Materials & Interfaces | 2015

Deep-Red Emissive Crescent-Shaped Fluorescent Dyes: Substituent Effect on Live Cell Imaging

Weimin Liu; Bingjiang Zhou; Guangle Niu; Jiechao Ge; Jiasheng Wu; Hongyan Zhang; Haitao Xu; Pengfei Wang

A series of crescent-shaped fluorescent dyes (CP1-CP6) were synthesized by hybridizing coumarin and pyronin moieties with different amino substituents at both ends. The molecular structures and photophysical properties of these fluorescent dyes were investigated through X-ray diffraction, absorption spectroscopy, and fluorescence spectroscopy. Results show that the fluorescent dyes exhibited crescent-shaped structures, deep-red emissions (approximately 650 nm), and significant Stokes shifts. In live-cell-imaging experiments, CP1 stains mitochondria, whereas CP3 and CP6 stain the lysosomes in a cytoplasm and the RNA in nucleoli. The relationships between different amino substituent groups and the imaging properties of CP dyes were discussed as well. Additionally, findings from the cytotoxicity and photostability experiments on living cells indicated the favorable biocompatibility and high photostability of the CP dyes.


Journal of Organic Chemistry | 2016

Deep-Red and Near-Infrared Xanthene Dyes for Rapid Live Cell Imaging.

Guangle Niu; Weimin Liu; Bingjiang Zhou; Hongyan Xiao; Hongyan Zhang; Jiasheng Wu; Jiechao Ge; Pengfei Wang

In this work, two xanthene dyes (H-hNR and TF-hNR) have been synthesized by a convenient and efficient method. These two dyes exhibited deep-red and near-infrared emissions, high fluorescence quantum yields, and good photostability. Their structure-optical properties were investigated by X-ray crystal structure analysis and density functional theory calculations. Live cell imaging data revealed that H-hNR and TF-hNR could rapidly stain both A549 and HeLa cells with low concentrations. The excellent photophysical and imaging properties render them as promising candidates for use in live cell imaging.

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Pengfei Wang

Chinese Academy of Sciences

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Weimin Liu

Chinese Academy of Sciences

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Hongyan Zhang

Chinese Academy of Sciences

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Jiechao Ge

Chinese Academy of Sciences

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Guangle Niu

Chinese Academy of Sciences

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Jiasheng Wu

Chinese Academy of Sciences

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Qingyan Jia

Chinese Academy of Sciences

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Haitao Xu

Chinese Academy of Sciences

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Liang Guo

Chinese Academy of Sciences

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Xiang-Min Meng

Chinese Academy of Sciences

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