Bishan Zhou

A Convergent Route for the Total Synthesis of the Eleuthesides

A ring expansion/ring contraction sequence is one of the key steps in the stereoselective synthesis of the tricyclic eleutheside skeleton 2 from α-phellandrene 1. Eleuthesides are natural products that are isolated from different marine sources, and several of these compounds display taxol-like anticancer activity.

Synthetic explorations in the saframycin-ecteinascidin series: construction of major chiral subunits through catalytic asymmetric induction

The major subunits needed to reach the titled targets have been assembled by chemistry, which included p-Claisen rearrangement, asymmetric epoxidation and asymmetric dihydroxylation.

A novel face specific Mannich closure providing access to the saframycin-ecteinascidin series of piperazine based alkaloids

The Mannich-like closure of 10→6 directly provides the backbone stereochemistry required for the titled alkaloids, in contrast to the stereochemical outcome in a related earlier case (3→4).

Eine konvergente Route zur Totalsynthese der Eleutheside

Eine Sequenz aus Ringerweiterung und Ringverengung ist einer der Schlusselschritte bei der stereoselektiven Synthese des tricyclischen Eleuthesid-Grundgerusts 2 ausgehend von α-Phellandren 1. Eleutheside sind Naturstoffe, die aus unterschiedlichen marinen Quellen isoliert wurden und von denen einige taxolahnliche Wirkung haben.