Brian D. Storey

Double Layer in Ionic Liquids: Overscreening versus Crowding

We develop a simple Landau-Ginzburg-type continuum theory of solvent-free ionic liquids and use it to predict the structure of the electrical double layer. The model captures overscreening from short-range correlations, dominant at small voltages, and steric constraints of finite ion sizes, which prevail at large voltages. Increasing the voltage gradually suppresses overscreening in favor of the crowding of counterions in a condensed inner layer near the electrode. This prediction, the ion profiles, and the capacitance-voltage dependence are consistent with recent computer simulations and experiments on room-temperature ionic liquids, using a correlation length of order the ion size.

Water Vapour, Sonoluminescence and Sonochemistry

Sonoluminescence is the production of light from acoustically forced bubbles; sonochemistry is a related chemical processing technique. The two phenomena share a sensitive dependence on the liquid phase. The present work is an investigation of the fate and consequences of water vapour in the interior of strongly forced argon micro–bubbles. Due to the extreme nonlinearity of the volume oscillations, excess water vapour is trapped in the bubble during a rapid inertial collapse. Water vapour is prevented from exiting by relatively slow diffusion and non–equilibrium condensation at the bubble wall. By reducing the compression heating of the mixture and through primarily endothermic chemical reactions, the water vapour reduces the temperatures within the bubble significantly. The quantity and disposition of hydroxyl radicals produced within the bubble are studied in some detail, as this is of keen interest in sonochemistry. It was recently shown by Moss and co–workers that light emission from a sonoluminescence bubble depends sensitively on the water–vapour content. The quantity of trapped water vapour determined in the present analysis is in excellent agreement with the amount found by Moss and co–workers to match photon yields and pulse widths of recent experiments.

Instability of electrokinetic microchannel flows with conductivity gradients

Electrokinetic flow is leveraged in a variety of applications, and is a key enabler of on-chip electrophoresis systems. An important sub-class of electrokinetic devices aim to pump and control electrolyte working liquids with spatial gradients in conductivity. These high-gradient flows can become unstable under the application of a sufficiently strong electric field. In this work the instability physics is explored using theoretical and numerical analyses, as well as experimental observations. The flow in a long, rectangular-cross-section channel is considered. A conductivity gradient is assumed to be orthogonal to the main flow direction, and an electric field is applied in the streamwise direction. It is found that such a system exhibits a critical electric field above which the flow is highly unstable, resulting in fluctuating velocities and rapid stirring. Modeling results compare well with experimental observations. The model indicates that the fluid forces associated with the thin dimension of the c...

Clusters of circulating tumor cells traverse capillary-sized vessels.

Significance Metastasis is responsible for 90% of cancer-related deaths and is driven by tumor cells circulating in blood. However, it is believed that only individual tumor cells can reach distant organs because multicellular clusters are too large to pass through narrow capillaries. Here, we collected evidence by examining clusters in microscale devices, computational simulations, and animals, which suggest that this assumption is incorrect, and that clusters may transit through capillaries by unfolding into single-file chains. This previously unidentified cell behavior may explain why previous experiments reported that clusters were more efficient at seeding metastases than equal numbers of single tumor cells, and has led to a strategy that, if applied clinically, may reduce the incidence of metastasis in patients. Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of distant organ metastasis. However, it is currently assumed that CTC clusters are too large to pass through narrow vessels to reach these organs. Here, we present evidence that challenges this assumption through the use of microfluidic devices designed to mimic human capillary constrictions and CTC clusters obtained from patient and cancer cell origins. Over 90% of clusters containing up to 20 cells successfully traversed 5- to 10-μm constrictions even in whole blood. Clusters rapidly and reversibly reorganized into single-file chain-like geometries that substantially reduced their hydrodynamic resistances. Xenotransplantation of human CTC clusters into zebrafish showed similar reorganization and transit through capillary-sized vessels in vivo. Preliminary experiments demonstrated that clusters could be disrupted during transit using drugs that affected cellular interaction energies. These findings suggest that CTC clusters may contribute a greater role to tumor dissemination than previously believed and may point to strategies for combating CTC cluster-initiated metastasis.

Inertially driven inhomogeneities in violently collapsing bubbles: the validity of the Rayleigh–Plesset equation

When a bubble collapses mildly the interior pressure field is spatially uniform; this is an assumption often made to close the Rayleigh–Plesset equation of bubble dynamics. The present work is a study of the self-consistency of this assumption, particularly in the case of violent collapses. To begin, an approximation is developed for a spatially non-uniform pressure field, which in a violent collapse is inertially driven. Comparisons of this approximation show good agreement with direct numerical solutions of the compressible Navier–Stokes equations with heat and mass transfer. With knowledge of the departures from pressure uniformity in strongly forced bubbles, one is in a position to develop criteria to assess when pressure uniformity is a physically valid assumption, as well as the significance of wave motion in the gas. An examination of the Rayleigh–Plesset equation reveals that its solutions are quite accurate even in the case of significant inertially driven spatial inhomogeneity in the pressure field, and even when wave-like motions in the gas are present. This extends the range of utility of the Rayleigh–Plesset equation well into the regime where the Mach number is no longer small; at the same time the theory sheds light on the interior of a strongly forced bubble.

Effects of electrostatic correlations on electrokinetic phenomena.

The classical theory of electrokinetic phenomena is based on the mean-field approximation that the electric field acting on an individual ion is self-consistently determined by the local mean charge density. This paper considers situations, such as concentrated electrolytes, multivalent electrolytes, or solvent-free ionic liquids, where the mean-field approximation breaks down. A fourth-order modified Poisson equation is developed that captures the essential features in a simple continuum framework. The model is derived as a gradient approximation for nonlocal electrostatics of interacting effective charges, where the permittivity becomes a differential operator, scaled by a correlation length. The theory is able to capture subtle aspects of molecular simulations and allows for simple calculations of electrokinetic flows in correlated ionic fluids. Charge-density oscillations tend to reduce electro-osmotic flow and streaming current, and overscreening of surface charge can lead to flow reversal. These effects also help to explain the suppression of induced-charge electrokinetic phenomena at high salt concentrations.

Heat and mass transfer during the violent collapse of nonspherical bubbles

The very high speed of collapse of cavitation bubbles is responsible for a number of phenomena of interest in science and engineering: Luminescence, sonochemistry, cavitation damage, ultrasonic cleaning, etc. Strongly forced bubbles may collapse with such violence that the relatively slow processes of diffusion of the heat of compression and of excess vapor to the bubble wall are obviated. This leads to an approximately adiabatic system with nearly constant mass during the final stages of extreme collapses, accompanied by the evolution of sharp thermal and compositional boundary layers on either side of the interface. It is shown that the boundary layers, which are involved in the determination of the interfacial temperature through the balance of sensible and latent heats, may profitably be described mathematically through integral equations. This complements well the boundary integral solution of the fluid dynamics, which has been the basis of much progress in the field.

The Olin curriculum: thinking toward the future

In 1997, the F. W. Olin Foundation of New York established the Franklin W. Olin College of Engineering, Needham, MA, with the mission of creating an engineering school for the 21st century. Over the last five years, the college has transformed from an idea to a functioning entity that admitted its first freshman class in fall 2002. This paper describes the broad outlines of the Olin curriculum with some emphasis on the electrical and computer engineering degree. The curriculum incorporates the best practices from many other institutions as well as new ideas and approaches in an attempt to address the future of engineering education.

The Effect of Streamwise Vortices on the Frost Growth Rate in Developing Laminar Channel Flows

Abstract An experimental study is presented to assess the influence of streamwise vortices on frost growth in a steady, developing, laminar channel flow. Using a simple model and scale analysis, frost growth rate (ablimation) data are normalized with respect to temperature, humidity and time. Measurements from baseline experiments in a rectangular channel are found to be accurately correlated using the proposed scaling relation. Upon introducing streamwise vortices in the channel flow, frost growth still follows the scaling relation, but local growth rates were observed to increase by more than 7% in regions where the streamwise vortices induce a surface-normal flow toward the frost surface. Frost thickness measurements, flow visualization, and deposition patterns are used to explain these findings.

Radial Response of Individual Bubbles Subjected to Shock Wave Lithotripsy Pulses In Vitro

Direct measurements of individual bubble oscillations in lithotripsy fields have been performed using light-scattering techniques. Studies were performed with bubble clouds in gassy water as well as single levitated bubbles in degassed water. There is direct evidence that the bubble survives the inertial collapse, rebounding several times before breaking up. Bubble dynamics calculations agree well with the observations, provided that vapor trapping (a reduction in condensation during bubble collapse) is included. Furthermore, the afterbounces are dominated by vapor diffusion, not gas diffusion. Vapor trapping is important in limiting the collapse strength of bubbles, and in sonochemical activity.