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Brian Eugene Cunningham

Eli Lilly and Company

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Publication

Featured researches published by Brian Eugene Cunningham.

Bioorganic & Medicinal Chemistry Letters | 2015

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Timothy Paul Burkholder; Brian Eugene Cunningham; Joshua Ryan Clayton; Peter Ambrose Lander; Matthew L. Brown; Robert Anthony Doti; Gregory L. Durst; Chahrzad Montrose-Rafizadeh; Constance King; Harold E. Osborne; Robert M. Amos; Richard W. Zink; Lawrence E. Stramm; Thomas P. Burris; Guemalli R. Cardona; Debra L. Konkol; Charles Reidy; Michael E. Christe; Michael James Genin

The design, synthesis, and structure activity relationships for a novel series of indoles as potent, selective, thyroid hormone receptor β (TRβ) agonists is described. Compounds with >50× binding selectivity for TRβ over TRα were generated and evaluation of compound 1c from this series in a model of dyslipidemia demonstrated positive effects on plasma lipid endpoints in vivo.

Archive | 2000

Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists

Karin Briner; Joseph Paul Burkhart; Timothy Paul Burkholder; Brian Eugene Cunningham; Matthew Joseph Fisher; William Harlan Gritton; Shawn Christopher Miller; Jeffrey Thomas Mullaney; Matthew Robert Reinhard; Dennis Charles Thompson; Leonard L. Winneroski; Yanping Xu

Journal of Medicinal Chemistry | 2004

Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3

Thomas A. Engler; James Robert Henry; Sushant Malhotra; Brian Eugene Cunningham; Kelly Wayne Furness; Joseph T. Brozinick; Timothy Paul Burkholder; Michael P. Clay; Joshua Ryan Clayton; Clive Gideon Diefenbacher; Eric Hawkins; Philip W. Iversen; Yihong Li; Terry D. Lindstrom; Angela Lynn Marquart; Johnathan Alexander Mclean; David Mendel; Elizabeth A. Misener; Daniel A. Briere; John O'Toole; Warren J. Porter; Steven Queener; Jon K. Reel; Rebecca A. Owens; Richard A. Brier; Thomas E. Eessalu; Jill R. Wagner; and Robert M. Campbell; Renee Vaughn

Bioorganic & Medicinal Chemistry Letters | 2005

The development of potent and selective bisarylmaleimide GSK3 inhibitors.

Thomas A. Engler; Sushant Malhotra; Timothy Paul Burkholder; James Robert Henry; David Mendel; Warren J. Porter; Kelly Wayne Furness; Clive Gideon Diefenbacher; Angela Lynn Marquart; Jon K. Reel; Yihong Li; Joshua Ryan Clayton; Brian Eugene Cunningham; Johnathan Alexander Mclean; John C. O’Toole; Joseph T. Brozinick; Eric Hawkins; Elizabeth A. Misener; Daniel A. Briere; Richard A. Brier; Jill R. Wagner; Robert M. Campbell; Bryan D. Anderson; Renee Vaughn; Donald B. Bennett; Timothy I. Meier; James A. Cook

Archive | 2003

Pyrrole-2, 5-dione derivatives and their use as gsk-3 inhibitors

Pamela Ann Albaugh; Jochen Ammenn; Timothy Paul Burkholder; Joshua Ryan Clayton; Scott Eugene Conner; Brian Eugene Cunningham; Thomas A. Engler; Kelly Wayne Furness; James Robert Henry; Yihong Li; Sushant Malhotra; Mark Joseph Tebbe; Guoxin Zhu

Archive | 2003

Pyrrole-2, 5dione derivatives and their used as GSK-3 inhibitors

Pamela Ann Albaugh; Jochen Ammenn; Timothy Paul Burkholder; Joshua Ryan Clayton; Scott Eugene Conner; Brian Eugene Cunningham; Thomas A. Engler; Kelly Wayne Furness; James Robert Henry; Sushant Malhotra; Mark Joseph Tebbe; Guoxin Zhu; Yihong Li; Brian R. Berridge; Charles Edward Ruegg; John M. Sullivan

Archive | 2003

PYRROL-2,5-DION DERIVATE UND DEREN VERWENDUNG ALS GSK-3 INHIBITOREN

Pamela Ann Albaugh; Jochen Ammenn; Brian R. Berridge; Timothy Paul Burkholder; Joshua Ryan Clayton; Scott Eugene Conner; Brian Eugene Cunningham; Thomas A. Engler; Kelly Wayne Furness; James Robert Henry; YiHong Burlingame Li; Sushant Malhotra; Charles Edward Ruegg; John M. Sullivan; Mark Joseph Tebbe; Guoxin Zhu

Archive | 2003

Pyrrol-2,5-dion derivate und deren verwendung als gsk-3 inhibitoren Pyrrole-2,5-dione derivatives and their use as inhibitors of GSK-3

Pamela Ann Albaugh; Jochen Ammenn; Brian R. Berridge; Timothy Paul Burkholder; Joshua Ryan Clayton; Scott Eugene Conner; Brian Eugene Cunningham; Thomas A. Engler; Kelly Wayne Furness; James Robert Henry; YiHong Burlingame Li; Sushant Malhotra; Charles Edward Ruegg; John M. Sullivan; Mark Joseph Tebbe; Guoxin Zhu

Archive | 2000

Benzofurylpiperazines: 5-ht2c serotonin receptor agonists

Karin Briner; Joseph Paul Burkhart; Timothy Paul Burkholder; Brian Eugene Cunningham; Matthew Joseph Fisher; William Harlan Gritton; Shawn Christopher Miller; Jeffrey Thomas Mullaney; Matthew Robert Reinhard; Dennis Charles Thompson; Leonard L. Winneroski; Yanping Xu

Archive | 2000

Benzofurylpiperazines et benzofurylhomopiperazines: antagonistes de la serotonine

Karin Briner; Joseph Paul Burkhart; Timothy Paul Burkholder; Brian Eugene Cunningham; Matthew Joseph Fisher; William Harlan Gritton; Shawn Christopher Miller; Jeffrey Thomas Mullaney; Matthew Robert Reinhard; Dennis Charles Thompson; Leonard L. Winneroski; Yanping Xu

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Collaboration

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Timothy Paul Burkholder

Eli Lilly and Company

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Joshua Ryan Clayton

Eli Lilly and Company

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James Robert Henry

Eli Lilly and Company

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Kelly Wayne Furness

Eli Lilly and Company

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Sushant Malhotra

Eli Lilly and Company

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Thomas A. Engler

Eli Lilly and Company

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Dennis Charles Thompson

Eli Lilly and Company

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Guoxin Zhu

Eli Lilly and Company

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Jeffrey Thomas Mullaney

Eli Lilly and Company

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Jochen Ammenn

Eli Lilly and Company

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