Bruce Bejcek
Western Michigan University
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Publication
Featured researches published by Bruce Bejcek.
Molecular and Cellular Biochemistry | 2007
Denise Smith; Takeshi Shimamura; Stephanie Barbera; Bruce Bejcek
NF-κB is a family of transcription factors that have been shown to be elevated in a variety of tumor types and in some cases central to their survival and growth. Here we present evidence that U-87 MG and U-118 MG growth is regulated by NF-κB and controlled by PDGF. NF-κB activity was suppressed by a dominant negative mutant of the human PDGF type β receptor and PDGF-B chain neutralizing antibodies. Creation of cell lines that had inducible expression of shRNAs directed against either c-Rel or RelA inhibited growth almost 90% indicating that NF-κB plays a central role in glioblastoma growth.
Biosensors and Bioelectronics | 2010
Binu Baby Narakathu; Massood Z. Atashbar; Bruce Bejcek
An impedance based electrochemical biosensor was designed and fabricated for the detection of various chemical and biological species, with glass as substrate material and gold interdigitated electrodes. A flow cell with inlet and outlet ports for the microfluidic chamber was designed and fabricated using acrylic material with a reservoir volume of 78 μl. The feasibility of the fabricated sensor for detecting very low concentration of chemical and biological species was demonstrated. Electrochemical impedance spectroscopy (EIS) was employed as the detection technique. The impedance based response of the two-terminal device revealed a very high sensitivity with low concentrations of mouse monoclonal IgG, sarcosine, cadmium sulphide (CdS) and potassium chloride (KCl) at pico mole levels.
IEEE Sensors Journal | 2006
Massood Z. Atashbar; Bruce Bejcek; Srikanth Singamaneni
In this paper, we describe a single-wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules like Streptavidin and IgG. SWNTs have been employed for two types of sensing mechanisms. First, the changes in the electrical conductance of the carbon nanotube (CNT) matrix on noncovalent binding of the biomolecules to the side walls of the CNT and, second, quantification of mass uptake of the matrix on biomolecule incubation are presented. Both sensing mechanisms exhibited consistent and highly sensitive responses. Biomolecular immobilization on the CNT surface was monitored by atomic force microscopy
ieee sensors | 2004
Massood Z. Atashbar; Bruce Bejcek; Srikanth Singamaneni; S. Santucci
We describe a single wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules like Streptavidin and IgG. SWNTs have been employed for two types of sensing mechanisms: changes in the electrical conductance of the carbon nanotube matrix on non-covalent binding of biomolecules to the side walls of the carbon nanotubes; quantification of mass uptake of the matrix on biomolecule incubation. Both sensing mechanisms exhibit consistent and highly sensitive responses. Biomolecular immobilization on the carbon nanotube surface was monitored by atomic force microscopy.
MRS Proceedings | 2004
Massood Z. Atashbar; Bruce Bejcek; Srikanth Singamaneni
In this paper we describe a single wall carbon nanotube (SWNT) based biological sensor for the detection of biomolecules using streptavidin and IgG. Two types of sensing mechanisms have been used to demonstrate the ability of carbon nanotubes to form nanoscale biosensors. The first sensing mechanism involves a CNT based conduction sensor in which the decrease in the current was observed when the specific biomolecule was bound. In the second mechanism Quartz Crystal Microbalance (QCM) was used to quantify the mass of the biomolecule bound on the sidewalls of the carbon nanotube. Both sensing mechanisms proved to be efficient and consistent. Immobilization of the biomolecules on the carbon nanotube surface was confirmed by Atomic Force Microscopy.
ieee sensors | 2009
Binu Baby Narakathu; Bruce Bejcek; Massood Z. Atashbar
An impedance based electrochemical biosensor was designed and fabricated for the detection of various chemical and biological species, with glass as substrate material and gold electrodes. A flow cell with inlet and outlet ports for the micro fluidic chamber was designed and fabricated using an acrylic material with a reservoir volume of 78 µl. The feasibility of the fabricated sensor for detecting very low concentration of chemical and biological species was demonstrated. The impedance based response of the two-terminal device revealed a very high sensitivity with low concentrations of Potassium Chloride (KCl), Cadmium Sulphide (CdS), Mouse Monoclonal IgG, and D - Proline at pico mole levels.
Clinical and Translational Science | 2018
Nathan P. Coussens; G. Sitta Sittampalam; Rajarshi Guha; Kyle R. Brimacombe; Abigail Grossman; Thomas Dy Chung; Jeffrey R. Weidner; Terry Riss; O. Joseph Trask; Douglas S. Auld; Jayme L. Dahlin; Viswanath Devanaryan; Timothy L. Foley; James McGee; Steven D. Kahl; Stephen C. Kales; Michelle R. Arkin; Jonathan B. Baell; Bruce Bejcek; Neely Gal‐Edd; Marcie A. Glicksman; Joseph Haas; Philip W. Iversen; Marilu Hoeppner; Stacy Lathrop; Eric W. Sayers; Hanguan Liu; Bart Trawick; Julie McVey; Vance Lemmon
The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
Archive | 2004
G. Sitta Sittampalam; Nathan P. Coussens; Henrike Nelson; Michelle R. Arkin; Douglas S. Auld; Christopher M. Austin; Bruce Bejcek; Marcie A. Glicksman; James Inglese; Philip W. Iversen; Zhuyin Li; James McGee; Owen McManus; Lisa Minor; Andrew D. Napper; John M. Peltier; Terry Riss; O. Joseph Trask; Jeffrey R. Weidner
Sensors and Actuators B-chemical | 2005
Massood Z. Atashbar; Bruce Bejcek; Aditya Vijh; Srikanth Singamaneni
Journal of Pharmacological Sciences | 2008
Krystal N. Anderson; Bruce Bejcek