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Dive into the research topics where Bruce R. Blazar is active.

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Featured researches published by Bruce R. Blazar.


Biology of Blood and Marrow Transplantation | 1999

Dose and timing of interleukin(IL)-12 and timing and type of total-body irradiation : effects on graft-vs. -host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients

Megan Sykes; Denise A. Pearson; Patricia A. Taylor; Gregory L. Szot; Samuel Goldman; Bruce R. Blazar

Paradoxically, a single injection of recombinant murine interleukin (IL)-12 on the day of bone marrow transplantation (BMT) inhibits graft-vs.-host disease (GVHD) while preserving graft-vs.-leukemia (GVL) effects in lethally irradiated mice receiving fully MHC-mismatched bone marrow and spleen cells. These protective effects are mediated by interferon (IFN)-gamma, whose early secretion is induced by IL-12 treatment. We investigated the relationship of IL-12 dose and timing of administration, as well as timing and type of total-body irradiation (TBI), with the ability of IL-12 to inhibit GVHD or mediate toxicity. The results show that a relatively low dose of IL-12 (as little as 50 U in a single injection) can mediate significant GVHD protection. The timing of IL-12 administration, however, is a critical factor. IL-12 administered 1 hour before BMT was most protective, but protection was still observed when it was administered 1-12 hours after BMT. Delaying IL-12 administration to 36 hours post-BMT completely obviated its protective effect. Administration of a second IL-12 injection 6 days after BMT negated the protective effect of an initial injection at the time of BMT. While IL-12 protection was evident when TBI was administered by 137Cs-irradiator in one or two fractions on day -1 or day 0, the use of an X-irradiator to deliver TBI on day -1 was associated with marked IL-12 toxicity. Whereas the protective effect of IL-12 against GVHD depended on donor-derived IFN-gamma, toxicity depended on the ability of host cells to produce IFN-gamma. Careful studies are warranted to test the effects of IL-12 in the context of BMT with various conditioning regimens in large animal preclinical models before this novel approach to GVHD protection can be applied clinically.


Blood | 1995

Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts

Bruce R. Blazar; Patricia A. Taylor; S Smith; Da Vallera


Blood | 1995

Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor grafts

Bruce R. Blazar; Patricia A. Taylor; Angela Panoskaltsis-Mortari; Gary S. Gray; Da Vallera


Blood | 1995

In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities

Bruce R. Blazar; Patricia A. Taylor; Da Vallera


Blood | 1995

Adult bone marrow-derived pluripotent hematopoietic stem cells are engraftable when transferred in utero into moderately anemic fetal recipients

Bruce R. Blazar; Patricia A. Taylor; Da Vallera


Blood | 1994

Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow

Bruce R. Blazar; Patricia A. Taylor; Suren N. Sehgal; Daniel A. Vallera


Blood | 1992

Promotion of murine marrow alloengraftment and hematopoietic recovery across the major histocompatibility barrier by administration of recombinant human interleukin-1α

Bruce R. Blazar; M. B. Widmer; Patricia A. Taylor; Daniel A. Vallera


Blood | 1995

Therapy for ongoing graft-versus-host disease induced across the major or minor histocompatibility barrier in mice with anti-CD3F(ab')2-ricin toxin A chain immunotoxin

Da Vallera; Patricia A. Taylor; Angela Panoskaltsis-Mortari; Bruce R. Blazar


Archive | 2004

Role of T-Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation

Bruce R. Blazar; Patricia A. Taylor


Biology of Blood and Marrow Transplantation | 2004

The role of CD4+CD25+ T regulatory (Treg) cells in allogeneic bone marrow transplantation

Bruce R. Blazar; Angela Panoskaltsis-Mortari; Bruce L. Levine; Carl H. June; Philip J. Lucas; Ronald E. Gress; Jonathan S. Serody; Patricia A. Taylor

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Patricia A. Taylor

Medical College of Wisconsin

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Angela Panoskaltsis-Mortari

Science Applications International Corporation

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Daniel A. Vallera

Baylor College of Medicine

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Da Vallera

University of Minnesota

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Carl H. June

National Marrow Donor Program

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Wayne R. Godfrey

University of Pennsylvania

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