Bunya Aoki | Researchain

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Advances in Experimental Medicine and Biology | 1989

The Activity of AA-193, A New Uricosuric Agent, in Animals

Takashi Dan; Hiroshi Koga; Etsuro Onuma; Haruko Tanaka; Haruhiko Sato; Bunya Aoki

A new uricosuric agent, 5-chloro-7, 8-dihydro-3-phenylfuro[2, 3-g]-1, 2-benzisoxazole-7-carboxylic acid (AA–193), was compared with other uricosurics in the rat, mouse and cebus monkey.

The Journal of Antibiotics | 1986

SEMISYNTHETIC β-LACTAM ANTIBIOTICS

Nobuhiro Ohi; Bunya Aoki; Kanzi Moro; Toshihiko Kuroki; Naoyuki Sugimura; Takao Noto; Toshiyuki Nehashi; Masahiko Matsumoto; Hiroshi Okazaki; Isao Matsunaga

The synthesis and the relationship between in vitro and in vivo activities of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-R1-1-ureido]-2- phenylacetamido]penicillanic acids having C2 approximately 8 alkyl or substituted alkyl groups as the substituents (R1) are described. In this series, 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido] -2-phenylacetamido]penicillanic acid (1b, AO-1100) showed the most potent protective effect on mice in experimental Pseudomonas aeruginosa infections, although it did not have the strongest in vitro activity among the penicillins we synthesized.

The Journal of Antibiotics | 1986

Semisynthetic beta-lactam antibiotics. I. Synthesis and antibacterial activity of new ureidopenicillin derivatives having catechol moieties.

Nobuhiro Ohi; Bunya Aoki; Teizo Shinozaki; Kanzi Moro; Takao Noto; Toshiyuki Nehashi; Hiroshi Okazaki; Isao Matsunaga

The Journal of Antibiotics | 1987

Semisynthetic beta-lactam antibiotics. III. Effect on antibacterial activity and comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid.

Nobuhiro Ohi; Bunya Aoki; Kuroki T; Masahiko Matsumoto; Kojima K; Toshiyuki Nehashi

Chemical & Pharmaceutical Bulletin | 1987

Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate

Nobuhiro Ohi; Bunya Aoki; Teizo Shinozaki; Kanzi Moro; Toshio Kuroki; Takao Noto; Toshiyuki Nehashi; Masahiko Matsumoto; Hiroshi Okazaki; Isao Matsunaga

Chemical & Pharmaceutical Bulletin | 1967

Studies on Antiviral Agents. III. Synthesis of Tenuazonic Acid Derivatives.

Hidetaka Yuki; Yasuo Tohira; Bunya Aoki; Tokio Kano; Shinichi Takama; Tsuyoshi Yamazaki

Chemical & Pharmaceutical Bulletin | 1991

Studies on Uricosuric Diuretics. II. Substituted 7, 8-Dihydrofuro[2, 3-g]-1, 2-benzisoxazole-7-carboxylic Acids and 7, 8-Dihydrofuro[2, 3-g]benzoxazole-7-carboxylic Acids

Haruhiko Sato; Takashi Dan; Etsuro Onuma; Haruko Tanaka; Bunya Aoki; Hiroshi Koga

Journal of Medicinal Chemistry | 1991

Studies on uricosuric diuretics. 4. Three-dimensional structure-activity relationships and receptor mapping of (aryloxy)acetic acid diuretics.

Hiroshi Koga; Haruhiko Sato; Takashi Dan; Bunya Aoki

Archive | 1979

Penicillanic acid derivatives

Nobuhiro Oi; Bunya Aoki; Teizo Shinozaki; Kanji Moro; Isao Matsunaga; Takao Noto; Toshiyuki Nebashi; Yusuke Harada; Hisao Endo; Takao Kimura; Hiroshi Okazaki; Haruki Ogawa; Minoru Shindo

Chemical & Pharmaceutical Bulletin | 1967