Haruki Ogawa
Chugai Pharmaceutical Co.
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Immunopharmacology | 1983
Tsutomu Kawaguchi; Morio Suematsu; Hisako Masuda Koizumi; Hiroki Mitsui; Shigeo Suzuki; Takashi Matsuno; Haruki Ogawa; Kikuo Nomoto
Motility, adhesiveness, IL1 production, and inhibition of tumor cell growth in vitro were examined in murine peritoneal macrophages obtained after intraperitoneal injection of a streptococcal preparation OK-432, heat-inactivated OK-432 (HI-OK-432), and thioglycollate medium (TG). By varying the interval between intraperitoneal injection of OK-432 and the harvest of peritoneal macrophages, it was found that OK-432 induced a time-dependent multi-step alteration of these properties: step I increased motility on day 1: step II increased adhesiveness on day 2; and step II increased inhibition of tumor cell growth and IL1 production. During step III, the peritoneal macrophage population, including Ia-bearing cells, increased dramatically in the peritoneal cavities of OK-432-treated mice. In contrast, injection of either HI-OK-432 or TG, which lack antitumor activity in vivo, initiated steps I and II, but not step III. The Ia-bearing macrophages induced by OK-432 showed high ability of IL1 production, but low growth inhibitory activity against tumor cells. Based on these results, OK-432 seems to be performing a dual function: eliciting a new population of macrophages to the site of injection (heat stable function), and inducing two different populations of antitumor macrophages and Ia-bearing macrophages (heat unstable function).
Annals of the New York Academy of Sciences | 1983
Kazuhito Hisatsune; Sukekatsu Nozaki; Toshiaki Ishikawa; Mikio Hayashi; Kaneo Nogaki; Haruki Ogawa
The effects of tuftsin and one of its analogues (4 [lys]-tuftsin) on phagocytosis of Staphylococcus aureus and Candida albicans were investigated in mice and rabbits. Mice were intravenously or orally administered 1-25 mg of 4 [lys]-tuftsin per kg daily for 4 to 7 days. After the mice were further treated with cyclophosphamide, they were intravenously challenged with C. albicans. More than 50% of the mice infected with C. albicans were killed within 7 days, although only 20% to 40% of those infected with the same microbes after 4 [lys]-tuftsin treatment died. A combination of 4 [lys]-tuftsin and an antibiotic was found to be somewhat more effective than either one alone. Further, pretreatment with 4 [lys]-tuftsin depressed microbial growth in the kidneys of mice bearing S-180 tumors. Rabbit peritoneal macrophages and polymorphonuclear leukocytes were harvested by intraperitoneal injection of liquid paraffin and of glycogen solution, respectively. For in vitro study of phagocytosis, rabbit macrophages of polymorphonuclear leukocytes were incubated in Hanks solution together with S. aureus and the number of survivors was determined. Enhanced engulfing activity of macrophages and increased bactericidal activity of polymorphonuclear leukocytes were shown by the in vitro phagocytosis experiments. It is expected that 4 [lys]-tuftsin will be effective against infectious disease, especially in immunocompromised hosts such as patients with malignant tumors.
GANN Japanese Journal of Cancer Research | 1973
Tetsuo Ono; Sumiko Kurata; Kiyoshige Wakabayashi; Yutaka Sugawara; Motoo Saito; Haruki Ogawa
Archive | 1979
Yutaka Sugawara; Akihiro Yamamoto; Mitsuaki Handa; Hiroko Usami; Haruki Ogawa
The Journal of Antibiotics | 1976
Takao Noto; Toshiyuki Nehashi; Hisao Endo; Motoo Saito; Shuzo Matsubara; Yusuke Harada; Seikichi Suzuki; Haruki Ogawa; Kenjiro Koyama; Yasuko Kaneko; Sachiko Goto
Archive | 1979
Nobuhiro Oi; Bunya Aoki; Teizo Shinozaki; Kanji Moro; Isao Matsunaga; Takao Noto; Toshiyuki Nebashi; Yusuke Harada; Hisao Endo; Takao Kimura; Hiroshi Okazaki; Haruki Ogawa; Minoru Shindo
GANN Japanese Journal of Cancer Research | 1975
Seikichi Suzuki; Akihiro Yamamoto; Haruki Ogawa
Archive | 1978
Hideo Oishi; Takao Noto; Yoshiharu Nawata; Hiroshi Okazaki; Hiroshi Sasaki; Kunio Ando; Haruki Ogawa
The Journal of Antibiotics | 1976
Yusuke Harada; Shuzo Matsubara; Morio Kakimoto; Takao Noto; Toshiyuki Nehashi; Takao Kimura; Seikichi Suzuki; Haruki Ogawa; Kenjiro Koyama
Archive | 1978
Nobuhiro Ooi; Bunya Aoki; Teizou Shinozaki; Kanji Moro; Isao Matsunaga; Takao Nofuji; Toshiyuki Nehashi; Yuusuke Harada; Hisao Endou; Takao Kimura; Hiroshi Okazaki; Haruki Ogawa; Minoru Shindou