Bw Chen

Differential Helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South China

Background: Carriers of Helicobacter pylori are believed to have a three‐ to six‐fold increased risk of developing gastric cancer. We have recently conducted a simultaneous cross‐sectional population study on the prevalence of H. pylori infection in a cohort of asymptomatic adult volunteers in two contrasting gastric cancer risk regions of South China, Hong Kong and Changle of Fujian. Their mean annual gastric cancer mortality has been approximately 7.5 and 75/100 000 population, respectively, since the beginning of the last decade. The aim of this study was to evaluate if H. pylori prevalence bears any relationship to gastric cancer mortality rates in these two southern regions of China.

Zinc sulphate solution enema decreases inflammation in experimental colitis in rats

Background : It has been reported that zinc sulphate contributes an anti‐inflammatory action in many animal models; however, the impact of zinc in colitis remains unclear. The aim of the present study was to examine the role of zinc sulphate in experimental colitis.

Seroprevalence of cytotoxin‐associated gene A positive Helicobacter pylori strains in Changle, an area with very high prevalence of gastric cancer in South China

: Helicobacter pylori, especially the CagA‐positive strains, are closely associated with peptic ulcers and gastric cancers. We performed a large scale gastric cancer screening project and examined the prevalence of H. pylori and CagA‐positive strains in Changle, China, an area with one of the World’s highest gastric cancer mortality. We also compared the prevalence with that in Hong Kong which has one‐tenth of the gastric cancer mortality of that in Changle.

Gastric cytoprotection by amoxycillin in the rat

Abstract Amoxycillin in combination with anti‐ulcer agents has been shown to prolong duodenal ulcer remission. While this effect can be related to the eradication of Helicobacter pylori, it is not known if amoxycillin might possess cytoprotective properties. Protection against ethanol‐induced gastric mucosal damage by intragastric instillation of amoxycillin suspension (prepared from capsule form) and solution (from injection form, 100% pure amoxycillin), and by intraperitoneal injection of amoxycillin solution was studied using an ex vivo gastric chamber in the rat. Intragastric and intraperitoneal administration of amoxycillin dose‐dependently protected the rat gastric mucosa from damage by absolute ethanol. This protection was lost when the rats were pretreated with indomethacin. Gastric mucosal blood flow as measured by laser Doppler flowmetry and gastric acid output were unaffected by amoxycillin. Amoxycillin imparts gastric cytoprotection, and one possible mechanism is by the release of prostaglandins.

CagA does not increase the prevalence of atrophic gastritis and intestinal metaplasia in a high gastric cancer risk region in China

Second Western Pacific Helicobacter Congress, Kota Kinabalu, Sabah, Malaysia, 25-27 June 1998. In Journal of Gastroenterology and Hepatology, 1998, v. 13 no. 7, p. A94, abstract no. D15

Age is a predicting factor for the association between CagA positive Helicobacter pylori (Hp) infection and serum pepsinogen I:II ratio in a high gastric cancer risk region in China

• G1359 AGE IS A PREDICTING FACTOR FOR THE ASSOCIATION BETWEEN CagA POSITIVE HELICOBACTER PYLORI (Hp) INFECTION AND SERUM PEPSINOGEN I:II RATIO IN A HIGH GASTRIC CANCER RISK REGION IN CHINA. BCY Wone. SK Lam, CK Ching, J Ho, ST Yuen, E Kwok, WHC Hu, KC Lai, LY Ong, Z Gao, JS Chen, BW Chen, XW Jiang, XH Hou, JY Lu, WH Wang, K Miki, A Covacci. Department of Medicine & Pathology, University of Hong Kong, Hong Kong; Public Health Bureau, Changle, and Changle Institute for Cancer Research, Fujian, China, First Dept of Internal Medicine, University of Tokyo, Japan, and *Immunobiological Research Institute, Siena, Italy.