C. Laresche

Increased Levels of Circulating Microparticles Are Associated with Increased Procoagulant Activity in Patients with Cutaneous Malignant Melanoma

Microparticles (MPs) are known to be increased in various malignancies and are involved in tumor invasion, angiogenesis, coagulation, and metastasis. We investigated the plasma levels of annexin-V MPs (AV(+)MPs), platelet-derived MPs (PMPs), and endothelial-derived MPs (EMPs) in patients with melanoma (n=129) and in healthy controls (n=49). A functional coagulation test STA Procoag-PPL measuring the clotting time was performed on samples containing MPs to evaluate their procoagulant potential. The plasma levels of PMPs, EMPs, and AV(+)MPs were significantly higher, and the clotting time-PPL was significantly lower in melanoma patients than in healthy controls. The plasma levels of PMPs, EMPs, and AV(+)MPs were higher in stage IV than in the other stages of melanoma, but with no significant difference. In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis.

Kaposi's sarcoma: a population‐based cancer registry descriptive study of 57 consecutive cases diagnosed between 1977 and 2009

There are few epidemiological data available on rare skin cancer, including Kaposis sarcoma (KS), which is a multifocal illness affecting the skin, mucosa, and viscera. Four different types of KS have been described: classic, AIDS‐associated, iatrogenic, and African. The purpose of this study was to describe the epidemiology and evolution of the different types of KS in the Doubs region of France.

Increased levels of circulating platelet-derived microparticles are associated with metastatic cutaneous melanoma

We investigated the plasma levels of PMPs in patients with 45 stage III and 45 stage IV melanoma. PMPs were characterised by flow cytometry and their thrombogenic activity. We also investigated the link between PMPs circulating levels and tumor burden. The circulating levels of PMPs were significantly higher in stage IV (8500 μL−1) than in patients with stage III (2041 μL−1) melanoma (P=.0001). We calculated a highly specific (93.3%) and predictive (91.7%) cut‐off value (5311 μL−1) allowing the distinction between high‐risk stage III and metastatic stage IV melanoma. The thrombogenic activity of PMPs was significantly higher in patients with stage IV melanoma (clotting time: 40.7 second vs 65 second, P=.0001). There was no significant association between the radiological tumoral syndrome and the plasma level of PMPs. Our data suggest the role of PMPs in metastatic progression of melanoma.

Étude épidémiologique rétrospective descriptive de la maladie de Kaposi dans le Doubs sur la période 1977 à 2009

faite par le DLQI. Il par ailleurs été observé une excellente acceptation du FSFI par les patientes. Conclusion.— Notre étude a permis de mettre en évidence que les patientes atteintes de PV ont une forte altération du bien-être sexuel et principalement celles souffrant de PV cancéreuse et précancéreuse. Il est donc important que ce bien être sexuel puisse être pris en compte au cours d’une consultation de PV. Le FSFI peut répondre à ce besoin car il est un outil largement accepté par les femmes et d’utilisation aisée. Déclaration d’intérêt.— Aucun.

Le blueberry muffin baby : à propos de deux cas ☆

P46 Le blueberry muffin baby : à propos de deux cas C. Laresche a,∗, E. Puzenat a, S. Penz a, E. Plouvier b, F. Aubin a,c,d, P. Humbert a,c,e a Dermatologie, CHU, Besançon, France b Hémato-pédiatrie, CHU, Besançon, France c Université de Franche-Comté, Besançon, France d EA3181, IFR133, Besançon, France e Inserm U645, IFR133, Besançon, France Iconographie disponible sur CD et Internet. ∗ Auteur correspondant.