C. Ross Ethier

Piping systems, frictionfactors, and drag coefficients

Consider the case of mitral regurgitation. If the connection between the ventricle and atrium can be treated as a hole of diameter 0.2xa0cm, estimate the rate of leakage from the ventricle into the atrium at a time when the ventricular pressure is 100xa0mmxa0Hg and the atrial pressure is 10xa0mmxa0Hg. (Note that 760xa0mmxa0Hg =xa01.01xa0×xa010 5 xa0Pa.) You can neglect unsteadiness. Use a blood density of 1.06xa0g/cm 3 and a viscosity of 0.04xa0g/cmxa0perxa0s. One way to measure cardiac output is to inject a tracer into the blood stream and watch how quickly it disperses. This requires a rapid injection of tracer, which is often done by using a tracer-injector device. One such injector consists of a large syringe that creates a pressure of 300 kPa. The tracer flows from the injector through 4 m of smooth plastic tubing of internal diameter 3 mm, then through a smooth 23-gauge needle (4 cm long, internal diameter 0.455 mm) before entering a peripheral vein where the pressure is 10 mm Hg (1.333 kPa). Neglecting minor losses and the height difference between the injector and the vein, what will the flow rate of tracer be?