Can Ceylan

Non‐Melanoma Skin Cancers between the Years of 1990 and 1999 in Izmir, Turkey: Demographic and Clinicopathological Characteristics

The incidence of nonmelanoma skin cancers (NMSCs) has been rapidly increasing in epidemic proportions all over the world. The purpose was to evaluate the demographic and clinico‐pathological patterns of skin cancers in Izmir, a region with high ultraviolet light exposure. The study was retrospective and hospital‐based. The data related to all NMSC patients registered from January 1, 1990, to December 31, 1999, in the Dermatology Department of Ege University Medical School in Izmir, were collected and analyzed according to the personal statistics, anatomic location, dimensions of the lesion and clinical and histopathological type of skin cancer. A total number of 2,879 patients, aged between 20 and 96 years, were included in the study; among them 1,633 were men and 1,246 were women. The mean age of the patient population was 62.81 years, with a standard deviation of 12.50 years. Among the tumour patients, there were 2,062 basal cell carcinomas (BCCs), 746 squamous cell carcinomas (SCCs) and 71 both BCC and SCC; the total number of lesions was 3,186 (2,339 BCCs, 847 SCCs). Of all the NMSC lesions studied, the highest percentage (46.6%) were located on the face. For the BCCs, the most frequent histopathological subtype was the solid pattern (50.74%). The mean male: female ratios for SCC and BCC lesions were 2.86 and 1.01, respectively. Nodular and ulcerative forms (69.8%) were the most commonly found clinical types. Of all NMSCs, 78.4% had diameters in the 11 to 20 mm. BCC is the most common type of skin cancer diagnosed in our region. Among the NMSC patients, farming was the most widespread and risky job. The majority of SCC tumors were observed mostly in men 60 years old or above. This is the first comprehensive description of NMSCs in our region.

Skin diseases in Turkish renal transplant recipients.

Background  Organ transplant recipients are predisposed to a variety of cutaneous complications due to immunosuppressive therapy. We aimed to determine the prevalence and the clinical spectrum of skin diseases in renal transplant recipients (RTRs).

Long-term Follow-up of Positive Surgical Margins in Basal Cell Carcinoma of the Face.

BACKGROUND Basal cell carcinoma (BCC) in central facial locations and tumors with positive margins are at a higher risk of recurrence. The most effective treatment is total excision, which includes an adequate pathological margin. OBJECTIVE To evaluate the outcome of the patients who underwent surgery for BCCs of the head and neck and of those who had positive surgical margins where Mohs surgery is not available. METHODS This study was conducted at Ege University Medical School between 2004 and 2014. One hundred thirty patients with 154 BCC who underwent surgical excision were included. In the histopathologic report, the existence of positive margin, BCC subtype, localization of the tumor, and distance of margins to the tumor were evaluated. RESULTS Twenty-three lesions (14.9%) of 22 patients revealed positive surgical margins. Six patients (26.1%) had recurrences on the surgical site. The BCC subtypes of recurrent patients were reported to be multifocal superficial in 2 (33.3%), infiltrative (16.7%) in 1, and micronodular (50%) in 3. CONCLUSION Patients with superficial multifocal or micronodular tumors should undergo reoperation because of high recurrence rates.

Isotretinoin (13‐Cis‐Retinoic Acid) Associated Atrial Tachycardia

We describe a 16‐year‐old boy who presented with palpitations for 1 week while being on isotretinoin treatment for nodulocystic facial acne for 3 months. Twenty four‐hour Holter monitoring showed frequent premature atrial beats and episodes of nonsustained atrial tachycardia. He never had any episodes of palpitations previously. His complaints almost disappeared within a week after stopping the treatment. He remained asymptomatic since the discontinuation of the drug. The temporal relationship between isotretinoin treatment and patients symptoms in the presence of documented arrhythmia suggests a drug‐related cause. As a result, clinicians should be aware of the possible arrhythmogenic effect of isotretinoin.

Two Cases of Acneiform Eruption Induced by Inhibitor of Epidermal Growth Factor Receptor

Background: Cetuximab is a member of a new family of antineoplastic agents that inhibit the epidermal growth factor receptor (EGF-R), and which are increasingly being used in the treatment of solid tumors. Methods: We have observed new secondary side effects. We present here 2 patients with acneiform eruption secondary to the administration of cetuximab (IMC-C225, Erbitux). The diagnoses of these patients were adenocarcinoma. Results: Histologically, a superficial purulent folliculitis and disordered differentiation with focal parakeratosis were observed. The follicular eruption responded favorably to treatment with 5% benzoyl peroxide and 4% erythromycin gel. These lesions healed within a few days after treatment. Conclusion: The cutaneous adverse effects of cetuximab are similar to other EGF-R-targeted agents and result from direct interference with the functions of EGF-R signaling in the skin.

A case of basal cell carcinoma arising in epidermal nevus

A 24‐year‐old man was admitted to our outpatient clinic with lesions in a linear configuration. On dermatologic examination, widespread, dark brown, warty papules and plaques over an erythematous base, following Blaschkos lines, extended from the middle of the chest to the right arm. These lesions had been present on the chest since birth and had gradually extended during childhood. Recently, a nodular lesion had appeared in the pre‐existing epidermal nevus in the middle part of the chest ( Fig. 1 ). The nodular lesion was totally excised by a plastic surgeon.

White fibrous papulosis of the neck

A 56-year-old white man with multiple, discrete nonfollicular papules on the neck is presented. Clinical and histopathologic features were compatible with the entity of white fibrous papulosis of the neck (WFPN). Pseudoxanthoma elasticum–like papillary dermal elastolysis (PXE-PDE) and WFPN are further clinicopathologic patterns of intrinsic aging. Clinically, WFPN is characterized by isolated, whitish papules, whereas those of PXE-PDE are yellowish and often coalesce to form “cobblestone” plaques. Our case showed clearly marginated whitish papules. The major histopathologic feature of WFPN is superficial dermal fibrosis with scant elastolysis; in PXE-PDE, there is papillary dermal elastolysis but no sign of fibrosis. No recurrence was performed in the 3 years’ follow-up in our case. Surgical treatment may be considered in such cases with well-circumscribed lesions.

Delayed Diagnosis in a Case of Lupus Vulgaris with Unusual Localization

Lupus vulgaris is the most common form of cutaneous tuberculosis, and the usual sites of involvement are the head and neck. We present a forty‐six‐year‐old woman with lupus vulgaris on the external surface of the left leg and foot, an unusual site. Based on histopathological and clinical features, this case was diagnosed as lupus vulgaris with unusual localization.

Tuberculosis Cutis Orificialis in Adalimumab Related Immunosupressive Patient

114 Ann Dermatol Received October 27, 2015, Revised December 26, 2015, Accepted for publication January 7, 2016 Corresponding author: Mehdi Iskandarli, Department of Dermatology and Venereology, Ege University Faculty of Medicine, Ankara Street 31, Bornova, Izmir 35100, Turkey. Tel: 90-5545955552, Fax: 90-2323903399, E-mail: nerman111@yahoo.com This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright

PARAPSORİASİS PLAĞINDA TOPİKAL FOTODİNAMİK TEDAVİ

Fotodinamik tedavi, aktinik keratoz, Bowen hastaligi, melanom disi deri kanserleri gibi epitelyal prekanseroz ve kanseroz lezyonlarda etkili bir tedavi yontemidir. Isiga duyarlandirici madde ile isigin etkilesimi sonucu ortaya cikan reaktif oksijen ara urunlerinin hastalikli dokuyu tahrip etmesi prensibine dayanir. Buyuk plak tipi parapsoriasis, mikozis fungoidese donusebilen bir Iezyondur. Bu calismanin amaci buyuk plak tipi parapsoriasiste fotodinamik tedavinin etkinligini saptamaktir. Calisma kontrol grubu olmayan pilot calisma olarak yapilmistir. Bu amacla 70 yasindaki plak parapsoriasisli hasta tedavi edildi. Tedavi oncesinde histopatolojik ve klinik degerlendirme yapildi. Daha sonra lezyon, yerel 5- aminolevulinik asit uygulamasini takiben inkoherent isik kaynagi ile isinlanmak suretiyie tedavi edildi. Isinlama sirasinda 580-720 nm dalga boyunda kirmizi isik bandi kullanildi. Onsekiz aylik takip sonucu rekurrens bulgusu saptanmadi.