Can Hasdemir

Demonstration of ventricular myocardial extensions into the pulmonary artery and aorta beyond the ventriculo-arterial junction.

Background: A subgroup of outflow tract (OT) ventricular tachycardias (VT) originate from the aortic sinuses or the main stem of the pulmonary artery. The anatomic substrate for these tachycardias is unknown. The aim of this study was to investigate the presence of ventricular myocardial extensions (VME) into the pulmonary artery (PA) and aorta (Ao) beyond the ventriculo‐arterial junction (VAJ) and determine the anatomical and histological characteristics of these muscle extensions.

Tachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors.

Idiopathic Ventricular Arrhythmias and Cardiomyopathy.u2002Introduction: Idiopathic ventricular arrhythmias in the form of monomorphic premature ventricular contractions (PVC) and/or ventricular tachycardia (VT) can cause tachycardia‐induced cardiomyopathy (TICMP). The aim of this study was to determine the incidence, clinical and electrophysiologic characteristics, and the predictors of TICMP in patients with idiopathic ventricular arrhythmias.

Late Gadolinium Enhancement CMR in Patients with Tachycardia-Induced Cardiomyopathy Caused by Idiopathic Ventricular Arrhythmias

Background: u2002Idiopathic ventricular arrhythmias in the form of monomorphic premature ventricular contractions (PVC) and/or ventricular tachycardia (VT) can cause tachycardia‐induced cardiomyopathy (TICMP). The aim of this study was to determine the prevalence of late gadolinium enhancement (LGE) in patients with TICMP caused by idiopathic ventricular arrhythmias.

Transcriptional Profiling of Septal Wall of the Right Ventricular Outflow Tract in Patients with Idiopathic Ventricular Arrhythmias

Background: Frequent, monomorphic premature ventricular contractions (PVC) and/or ventricular tachycardia (VT) in patients with structurally normal heart usually arise from the right ventricular outflow tract (RVOT). The underlying arrhythmogenic substrate for the genesis of RVOT tachycardias is largely unknown. The aim of this study was to investigate the genome‐wide transcriptional profiling of the septal wall of the RVOT in patients with RVOT tachycardia and control subjects.

Time Course of Recovery of Left Ventricular Systolic Dysfunction in Patients with Premature Ventricular Contraction-Induced Cardiomyopathy.

Idiopathic ventricular arrhythmias in the form of frequent, monomorphic premature ventricular contractions (PVC) can cause PVC‐induced cardiomyopathy (PICMP). The aim of this study was to determine the baseline echocardiographic characteristics and the time course and degree of recovery of left ventricular (LV) systolic dysfunction in patients with PICMP.

Human Model Simulating Right Ventricular Outflow Tract Tachycardia by High-Frequency Stimulation in the Left Pulmonary Artery: Autonomics and Idiopathic Ventricular Arrhythmias

Introduction: Frequent monomorphic premature ventricular contractions (PVC) and/or ventricular tachycardia (VT) in patients with structurally normal heart usually arise from the right ventricular outflow tract (RVOT). An animal model simulating RVOT tachycardia by high‐frequency stimulation (HFS) of the sympathetic input to the proximal pulmonary artery (PA) has been previously described. The aim of this study was to similarly induce RVOT tachycardia in humans.

Increased Myocardial Collagen Turnover in Patients with Progressive Cardiac Conduction Disease

Background: Histopathologically, progressive cardiac conduction disease (PCCD) is characterized by progressive fibrosis and sclerodegenerative changes in the proximal and distal conduction system of the heart. Therefore, we sought to determine the serum levels of myocardial collagen turnover markers, extracellular matrix components, transforming growth factor β1 (TGFβ1), and bone morphogenic protein‐7 (BMP‐7) in this population.

β1 and β2‐Adrenergic Receptor Polymorphisms and Idiopathic Ventricular Arrhythmias

Introduction: Idiopathic ventricular arrhythmias commonly refer to ventricular tachycardia (VT) and/or frequent/monomorphic premature ventricular contractions (PVC) in patients with structurally normal heart. Activation of sympathetic tone has been shown to play an important role in the provocation and maintenance of these arrhythmias. We investigated whether common single nucleotide polymorphisms in the β1 and β2‐adrenergic receptors are associated with idiopathic ventricular arrhythmias.

Giant Right Atrial Diverticulum Associated with Wolff‐Parkinson‐White Syndrome

Giant Right Atrial Diverticulum Associated with Wolff-Parkinson-White Syndrome CAN HASDEMIR, M.D.,∗ CEMIL GURGUN, M.D.,∗ OGUZ YAVUZGIL, M.D.,∗ ALPER YUKSEL, M.D.,† and KAREN J. BECKMAN, M.D.‡ From the ∗Department of Cardiology, Ege University School of Medicine, Izmir, Turkey; †Department of Radiology, Kent Hospital, Izmir, Turkey; and ‡Department of Medicine, Cardiac Arrhythmia Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

Chronic cough and tachycardia-induced cardiomyopathy in a patient with idiopathic frequent, monomorphic premature ventricular contractions.

A 70‐year‐old woman presented with a 1‐year history of dry cough. Extensive work‐up ruled out common causes of chronic cough. She was found to have very frequent, monomorphic premature ventricular contractions (PVCs) and mild‐to‐moderate left ventricular systolic dysfunction. Propafenone 450 mg/day resulted in complete resolution of her cough and disappearance of PVCs within 24 hours of initiation. One month after the initiation of propafenone therapy, left ventricular ejection fraction normalized and her chronic cough resolved completely. (PACE 2013; 36:e156–e158)