Canan Alatlı

Clinical and histopathological investigation of odontomas: review of the literature and presentation of 160 cases.

PURPOSE The purpose of the present study was to evaluate the clinical and histopathologic aspects of different types of odontomas. MATERIALS AND METHODS One hundred sixty odontoma cases sent to the Institute of Oncology, Department of Tumor Pathology, Istanbul University from 1971 through 2010 were investigated. These tumors were compared by age of patient, gender of patient, localization, histopathologic type, clinical diagnosis, and clinical and microscopic features. RESULTS Odontomas were classified histopathologically as complex, compound, or mixed. Of all investigated cases, 99 were complex, 57 were compound, and 4 were mixed odontomas. The mean age at diagnosis was 27.9 years, and odontomas were diagnosed most frequently at 10 to 19 years of age. CONCLUSIONS From the perspective of community health, the presence of odontomas within the jaws is important because these constitute 21% to 67% of all odontogenic tumors. The present study showed 2 interesting findings that differed from previous studies. These are the lower incidence rate of odontomas within the category of odontogenic tumors and the higher incidence of complex odontomas over compound odontomas.

c-erbB-2 Gene Amplification in Nasopharyngeal Carcinoma

Abstract Amplification of the c-erbB-2 gene has been associated with poor prognosis in different types of cancer. However, there are no data on the c-erbB-2 expression levels in nasopharyngeal cancer. In this study, amplification of the gene has been investigated in the tumor tissue of patients with nasopharyngeal cancer by competitive polymerase chain reaction c-erbB-2 amplification was observed in 43.3% of the patients. The increase in the gene copy number correlated with the T stage. No correlation was found with lymph node involvement, histologic grade, differentiation, presence of metastases, or age and sex. We conclude that c-erbB-2 amplification may contribute to the pathogenesis of nasopharyngeal cancer. Our report is the first study investigating the expression of the c-erbB-2 gene in nasopharyngeal cancer at the DNA level.

Solitary plexiform neurofibroma of the oral cavity : A case report

A solitary plexiform neurofibroma localized on the vestibular side of the right mandible in a 37-year-old woman is described. The tumor was excised, and there was no recurrence after 2 years.

Hemangioma of the Peroneal Nerve: Case Report and Review of the Literature

A case of hemangioma of the peroneal nerve is presented. The tumor, which exerted compression on the main trunk of the peroneal nerve, was excised without causing damage to the nerve. Symptoms due to compression vanished within a month, and there was no recurrence in the 14 months that followed.

Odontogenic and nonodontogenic cysts in Istanbul: Analysis of 5088 cases

The aim of this study was to determine the prevalence of 5088 odontogenic and nonodontogenic cysts over a 40‐year period in the Turkish population and to compare results with findings in the literature.

The effects of supplemental melatonin administration on the healing of bone defects in streptozotocin-induced diabetic rats

ABSTRACT Diabetes mellitus (DM) causes an increased production of free radicals that can impair bone healing. Melatonin is a hormone secreted mainly by the pineal gland, which participates in the neutralization process of free radicals. Objective The aim of this study was to investigate histologic and biochemical effects of supplemental melatonin administration on bone healing and antioxidant defense mechanism in diabetic rats. Material and Methods Eighty-six Sprague-Dawley male rats were used in this study. Diabetes mellitus was induced by intraperitoneal (i.p.) administration of 65 mg/kg streptozotocin (STZ). Surgical bone defects were prepared in the tibia of each animal. Diabetic animals and those in control groups were treated either with daily melatonin (250 μg/animal/day/i.p.) diluted in ethanol, only ethanol, or sterile saline solution. Rats were humanely killed at the 10th and 30th postoperative days. Plasma levels of Advanced Oxidation Protein Products (AOPP), Malondialdehyde (MDA), and Superoxide Dismutase (SOD) were measured. The number of osteoblasts, blood vessels and the area of new mineralized tissue formation were calculated in histologic sections. Results At the 10th day, DM+MEL (rats receiving both STZ and melatonin) group had significantly higher number of osteoblasts and blood vessels as well as larger new mineralized tissue surfaces (p<0.05 for each) when compared with DM group. At the 30th day, DM group treated with melatonin had significantly lower levels of AOPP and MDA than those of DM group (p<0.05). Conclusion Melatonin administration in STZ induced diabetic rats reduced oxidative stress related biomarkers and showed beneficial effects on bone healing at short term.

Odontogenic lesions in a pediatric population: Review of the literature and presentation of 745 cases.

OBJECTIVES Pediatric odontogenic lesions are rare clinical entities and are not well addressed in the otolaryngology literature. Knowledge of the biologic and clinical behavior of these lesions and their basic features such as location and age are key aspects for otolaryngologists in developing an early clinical differential diagnosis, such that they can provide adequate treatment. METHODS Six thousand histologically-diagnosed odontogenic lesions from a 40-year period were reviewed. Pediatric patients (745 cases, 12.7%) aged up to 17 years were selected and reevaluated. The patients were divided into three age groups according to dentition periods: primary dentition (0-5 years), mixed dentition (6-12 years), and permanent dentition (13-17 years). Clinical data, including age, sex, and location, were collected from pathology records. RESULTS Of the total of 745 cases, 596 specimens (80%) were diagnosed as odontogenic cysts and 149 specimens (20%) were diagnosed as odontogenic tumors. The most frequent odontogenic cysts were radicular cysts (48.4%), followed by dentigerous cysts (16.7%). The most common odontogenic tumor was odontoma (8.05%). CONCLUSION This study shows that all odontogenic lesions in the pediatric group are benign. Odontogenic tumors are relatively rare in this age group. Knowledge of the biological and histopathological behaviors of odontogenic lesions and their basic features such as location and age is a key aspect for developing an early clinical differential diagnosis and providing adequate treatment.

Triester glycerol oxide in the treatment of recurrent aphthous stomatitis: A cytological investigation

Abstract Aim: The objective of the present study was to evaluate the clinical and cytological effects of a new topical gel, (Protefix) with triester glycerol oxide (TGO) on recurrent aphthous stomatitis (RAS). Method: In this study, 50 patients referred to the Department of Oral Diagnosis and Radiology, Marmara University, Faculty of Dentistry, were studied. A clinical examination, a complete review of past medical history, and a detailed history of RAS was performed in each patient. Clinical features of apthous ulcers and visual analogue scale values scraped (VAS) were recorded. Cytological examination was performed by collecting smear material scraped off the lesion surface. Triester glycerol oxide (TGO) gel (Protefix®, Queisser Pharma) was applied to lesions three times a day. Results: A significant reduction of the number of erythrocytes and inflammatory cells, and a significant increase of mature epithelial cells were observed. Conclusions: This treatment may be used as an initial strategy for reduct...

Abstract 4458: Discovery of novel epigenetic biomarkers in premalignant/malignant oral cavity lesions by methylation arrays

Purpose: The incidence of the oral squamous cell carcinoma (OSCC) is around 50% of all head and neck cancer (HNC), the sixth most common type of cancer in the world. Aberrant hyper/hypo-methylation in the promoter region of some known or putative tumor suppressor/protoonco-genes occurs frequently during the development of various cancers including OSCC. Both of genetic and environmental factors play roles in the carcinogenesis of malignant lesions. Etiological factors predisposing to OSCC are smoking, alcohol and tobacco consumption, snuffuse, viral factors, chronic irritation, iron and various vitamin deficiencies, poor oral hygiene and diseases such as syphilis. Despite the advances in cancer diagnosis and treatment, the 5-year survival rate of OSCC patients is poor and because of advanced stage of disease, it has high mortality and morbidity. Another the most important ethiological factor of OSCC is oral premalignant lesions (OPML), since OPML is related with malignant transformation. In our study, we included three different OPML associated with different risks of leading to malignancy: Oral leukoplakia has a high risk of conversion into malignancy, whereas oral lichen planus and oral lichenoid dysplasia are associated with lower risk. We aimed to investigate the epigenetic characterization of OSCC and OPML relative to the epigenetic changes in these groups. Experimental Design: Tumor and corresponding healthy tissues from 12 and 10 Turkish patients with OPML and OSCC, respectively were collected. The samples were analyzed histopatologically and after DNA extraction and bisulfite modification, methylation patterns of the samples were investigated by using the Illumina Infinium HumanMethylation450 (450K) BeadChip array. Results: According to our preliminary results obtained from the methylation array experiments, CpG regions in the UOX, ABCC12, FCRLB, ABL2, LGR6 and SLC22A18 genes were found unmethylated while CpGs located in YPEL-3 were highly methylated (p Conclusion: We concluded the UOX, ABCC12, FCRLB, ABL2, LGR6, SLC22A18 and YPEL-3 may be potential biomarker candidate genes playing role in the transformation mechanism of OPML/OSCC. In the further studies, we will compare the methylation patterns between OPML subgroups to discriminate the potential candidates. *This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK-SBAG-114S497). Citation Format: Semra Demokan, Sevde Comert, Cansu Ozkoklesen, Murat Ulusan, Gulsum Ak, Canan Alatli, Nejat Dalay. Discovery of novel epigenetic biomarkers in premalignant/malignant oral cavity lesions by methylation arrays. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4458.

ORAL SKUAMÖZ HÜCRELİ KARSİNOM: 3 OLGU SUNUMU VE LİTERATÜR DERLEMESİ

Skuamoz hucreli karsinom, oral kavitede en sik izlenen malignitedir. Agiz mukozasinin her bolgesinde gorulebilen bu karsinomlarda tutun ve alkol tuketimi onemli etkendir. Bu makalede son alti ay icinde klinigimizde tanisi konan, lokalizasyonlari bakimindan farkli uc oral skuamoz hucreli karsinom olgusu literatur bilgileri dogrultusunda sunulmustur. Anahtar kelimeler: Skuamoz hucreli karsinom, oral kavitede en sik izlenen malignitedir. Agiz mukozasinin her bolgesinde gorulebilen bu karsinomlarda tutun ve alkol tuketimi onemli etkendir. Bu makalede son alti ay icinde klinigimizde tanisi konan, lokalizasyonlari bakimindan farkli uc oral skuamoz hucreli karsinom olgusu literatur bilgileri dogrultusunda sunulmustur. Anahtar kelimeler: Skuamoz hucreli karsinom, oral kavite, diseti mukozasi, dil mukozasi ORAL SQUAMOUS CELL CARCINOMA: 3 CASE REPORT AND REVIEW OF LITERATURE ABSTRACT Squamous cell carcinoma is the most common malignancy affecting the oral cavity. Tobacco and alcohol consumption in these carcinomas can be seen in every region where the oral mucosa is an important factor. This article in the latest issue of our clinic diagnosed within six months in terms of localization of three different oral squamous cell carcinoma are presented in accordance with the literature. Key words: Squamous cell carcinoma, oral cavity, gingiva,, tongue ORAL SQUAMOUS CELL CARCINOMA: 3 CASE REPORT AND REVIEW OF LITERATURE ABSTRACT Squamous cell carcinoma is the most common malignancy affecting the oral cavity. Tobacco and alcohol consumption in these carcinomas can be seen in every region where the oral mucosa is an important factor. This article in the latest issue of our clinic diagnosed within six months in terms of localization of three different oral squamous cell carcinoma are presented in accordance with the literature. Key words: Squamous cell carcinoma, oral cavity, gingiva, tongue