Hülya Koçak

The Effects of Etodolac, Nimesulid and Naproxen Sodium on the Frequency of Sister Chromatid Exchange after Enclused Third Molars Surgery

Purpose Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. Materials and Methods In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use. Results There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium. Conclusion Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.

AĞIZ İÇİNDEKİ YUMUŞAK DOKU LEZYONLARINDA MAST HÜCRELERİNİN İNCELENMESİ-INVESTIGATION OF MAST CELLS IN ORAL SOFT TISSUE LESIONS

Ozet Degisik kimyasal maddeler salgilayarak damarlar ve bag dokusu hucrelerini etkileyen mast hucreleri, aller-jik reaksiyonlar, iltihap, yara iyilesmesi gibi cesitli fizyolojik ve patolojik olaylarda rol oynarlar. Bu calismada iltihapsal fibroz hiperplazi, iritasyon fibromu, peri-ferik fibrom, piyojenik granulom, hemanjiom ve peri-ferik dev hucreli reparatif granulom tanisi konmus agiz lezyonlarnida mast hucrelerinin yogunluk ve loka-lizasyonlari incelenmis, bulgular kaynak bilgileriyle karsilastirilarak tartisilmistir. Agiz icindeki lezyonlar-da mast hucrelerinin genellikle orta yogunlukta goruldugu epitel alti ve bag dokusu bolgelerinde daha fazla lokalize oldugu gozlenmistir. Agiz lezyonlarinda mast hucrelerinin cogunlukla bag dokusu icinde kollagen lif yapimi ile iliskili oldugu, epitel altinda gorulen muko-zal tipteki mast hucrelerinin ise travmaya ugramis epi-telin beslenmesi ile iliskili olabilecegi sonucuna varilmistir. Anahtar sozcukler: Mast hucresi, agiz lezyonlari, Abstract Mast celts, by releasing various chemical material affecting material affecting tlie vessels and connective tissue cells, play an important role in different physiological and pathological events, like allergic reactions, inflammation and wound heating. In the present study, the amount and the localization of the mast cells in certain oral lesions, as inflammatory fibrous hyperplasia, irritation fibroma, peripheral fibroma, granuloma pyogenicum, hemangioma and peripheral giant cell granuloma were investigated. Findings were compared and discussed with reference to those of the literature. Mast cells were generally observed in mild intensity and they were localized witliin the connective tissue and subepithelial region. In oral lesions most of the mast cells were found to be related to fibrous tissue formation. Mucosal type of mast cells, which were localized in close relation to the epitlielium were tiwugfit to have a role in the nutrition of Hie traumatic epithelium. Key words: Mast cell, oral lesions.