Carl A. Bunde

Glycogen in Alloxan-Treated Rats.

Summary Glycogen determinations were made on the heart, liver, and skeletal muscle of rats with alloxan-produced diabetes mellitus and on the same tissues of untreated controls. The alloxan-treated animals showed a statistically significant increase in glycogen content of heart muscle and a statistically significant decrease in liver and skeletal muscle glycogen. Rats which developed diabetes mellitus had a high blood sugar and high blood ketones at the time of autopsy. On histological examination of the tissues, the islet cells of alloxan-treated rats which developed diabetes showed a marked reduction in cytoplasm, pycnosis and decrease in size of the nuclei with resultant collapse of islet structure. Almost all kidney and liver sections showed some degenerative changes.

Suppression of Persisting Corpora Lutea in Hypophysectomized Rats.

Summary The character of persisting corpora lutea in hypophysectomized rats was not influenced by the injection of oestrin, progestin or the follicle stimulating hormone of the hypophysis. The luteinizing fraction, however, caused almost total regression of the corpora lutea with marked diminution of ovarian weight.

Failure of oral saccharine to influence blood sugar.

Summary Oral administration of saccharine to 10 normal subjects, fasted and at rest, did not influence the blood sugar during the subsequent 50 minutes.

Effect on Cardiac Glycogen of Intravenously Administered Sodium Acetoacetate, Sodium Beta-Hydroxybutyrate and Sodium Butyrate

Summary In experiments carried out on adult male white rats under sodium pentobarbital anaesthesia, intravenous administration of ketone bodies resulted in an increase in the glycogen stores of the heart. Concomitant increase in the glycogen stores of the liver and skeletal muscle did not occur.

Ascaricidal Action of Cadmium

Conclusion CdO mixed with dry ground grain and supplied as the only food for two or three days will effectively eliminate ascarids from pigs. The concentration shown to be effective is .01% to .02% and this mixture is palatable and readily eaten.