Benedict E. Abreu

Central nervous system effects of a local anesthetic, dyclonine.

Dyclonine (4-n-butoxy-β-(1-piperidyl)propiophenone HCl), a potent local anesthetic, acts as an anticonvulsant, multisynaptic spinal reflex depressant and central nervous system stimulant. Skeletal muscle tremors, convulsions, and emesis resulting from CNS stimulation are antagonized best by barbiturates, and less by meprobamate, chloral hydrate, chlorpromazine, pheniramine, diphenylhydantoin, and 3-methyl-1-pentyn-3-yl sodium succinate (P-408).

Morphine antagonism with amiphenazole (2, 4-diamino-5-phenyl-thiazole hydrochloride).

Summary Amiphenazole was effective in antagonizing morphine depression in dogs; bromosulfolane was less effective even at toxic doses. Amiphenazole did not significantly alter the analgetic effect of morphine in mice, though this compound alone produced a mild but transient analgetic effect.