Carl A. Schnaitman
Johns Hopkins University
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Featured researches published by Carl A. Schnaitman.
Biochemical and Biophysical Research Communications | 1968
Carl A. Schnaitman; Peter L. Pedersen
Abstract Intact rat liver mitochondria catalyze an ADP-ATP exchange which is partially inhibited by oligomycin and dinitrophenol ( Wadkins and Lehninger, 1963 ; Guillory and Slater, 1965 ). It has been postulated that the dinitrophenol- and oligomycin-sensitive ADP-ATP exchange reaction is catalyzed by the enzyme(s) participating in ATP formation during oxidative phosphorylation ( Wadkins and Lehninger, 1958 ; 1963 ). However, the presence of large amounts of adenylate kinase and nucleoside diphosphokinase, which catalyze oligomycin-insensitive ADP-ATP exchanges, has rendered further investigation of the oligomycin-sensitive exchange difficult. In this communication it is shown that when rat liver mitochondria are fractionated with digitonin the oligomycin-sensitive ADP-ATP exchange activity is recovered with the inner membrane-matrix fraction, while all of the nucleoside diphosphokinase and adenylate kinase activity is released with the outer membrane. The exchange activity found in the inner membrane-matrix fraction is localized in the inner membrane and is completely inhibited by oligomycin, dinitrophenol, and atractyloside when assayed in the absence of added Mg ++ . Thus, the oligomycin-sensitive ADP-ATP exchange activity observed in intact mitochondria does not appear to be catalyzed by nucleoside diphosphokinase or adenylate kinase.
Journal of Cell Biology | 1968
Carl A. Schnaitman; John W. Greenawalt
Journal of Cell Biology | 1967
Carl A. Schnaitman; V. Gene Erwin; John W. Greenawalt
Journal of Cell Biology | 1970
John W. Greenawalt; Carl A. Schnaitman
Journal of Biological Chemistry | 1974
Carolyn H. MacGregor; Carl A. Schnaitman; David E. Normansell; Martin G. Hodgins
Journal of Biological Chemistry | 1973
Sohair Farid Sabet; Carl A. Schnaitman
Journal of Cell Biology | 1971
Jochen W. Heine; Carl A. Schnaitman
Journal of Biological Chemistry | 1969
Peter L. Pedersen; Carl A. Schnaitman
Chemistry and Functions of Colicins | 1973
Sohair Farid Sabet; Carl A. Schnaitman
Biochemical and Biophysical Research Communications | 1969
Carl A. Schnaitman