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Featured researches published by Carl K. Winter.


Food and Chemical Toxicology | 2009

Comparison of pesticide exposure from consumption of domestic and imported fruits and vegetables.

Josh M. Katz; Carl K. Winter

Estimates of daily dietary human exposure to 18 common pesticides found in fruits and vegetables were developed from residue data obtained from the 2003 US Food and Drug Administrations Regulatory Monitoring Program using probabilistic dietary exposure modeling. The differences between the exposures from domestic versus imported fruit and vegetable residues were compared. Of the 15 pesticides for which quantifiable residues were detected from both domestic and imported fruit and vegetable samples, domestic exposures were significantly higher for 11 pesticides while imported exposures were higher for the remaining four. The five pesticides showing the highest exposures all demonstrated greater domestic exposures than imported exposures. The mean daily exposure estimate for one pesticide, methamidophos, was above the reference dose for domestic fruits and vegetables while slightly below the reference dose for imported fruits and vegetables. Exposures to the other 17 pesticides were well below the established reference doses for domestic and imported fruits and vegetables. Exposure from pesticides in domestic foods exceeds exposure from imported foods and demonstrates that probabilistic modeling of dietary exposure provides more useful information concerning the relative risks of domestic and imported foods than that obtained from the traditional comparisons of residue detection frequency and violation rates.


Advances in Experimental Medicine and Biology | 1996

Chemistry and biological activity of AAL toxins

Carl K. Winter; David G. Gilchrist; Martin B. Dickman; Clinton Jones

AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matricies and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins.


Journal of Agricultural and Food Chemistry | 2012

Pesticide Residues in Imported, Organic, and “Suspect” Fruits and Vegetables

Carl K. Winter

Consumers are frequently urged to avoid imported foods as well as specific fruits and vegetables due to health concerns from pesticide residues and are often encouraged to choose organic fruits and vegetables rather than conventional forms. Studies have demonstrated that while organic fruits and vegetables have lower levels of pesticide residues than do conventional fruits and vegetables, pesticide residues are still frequently detected on organic fruits and vegetables; typical dietary consumer exposure to pesticide residues from conventional fruits and vegetables does not appear to be of health significance. Similarly, research does not demonstrate that imported fruits and vegetables pose greater risks from pesticide residues than do domestic fruits and vegetables or that specific fruits and vegetables singled out as being the most highly contaminated by pesticides should be avoided in their conventional forms.


Journal of Toxicology | 2011

Dietary Exposure to Pesticide Residues from Commodities Alleged to Contain the Highest Contamination Levels

Carl K. Winter; Josh M. Katz

Probabilistic techniques were used to characterize dietary exposure of consumers to pesticides found in twelve commodities implicated as having the greatest potential for pesticide residue contamination by a United States-based environmental advocacy group. Estimates of exposures were derived for the ten most frequently detected pesticide residues on each of the twelve commodities based upon residue findings from the United States Department of Agricultures Pesticide Data Program. All pesticide exposure estimates were well below established chronic reference doses (RfDs). Only one of the 120 exposure estimates exceeded 1% of the RfD (methamidophos on bell peppers at 2% of the RfD), and only seven exposure estimates (5.8 percent) exceeded 0.1% of the RfD. Three quarters of the pesticide/commodity combinations demonstrated exposure estimates below 0.01% of the RfD (corresponding to exposures one million times below chronic No Observable Adverse Effect Levels from animal toxicology studies), and 40.8% had exposure estimates below 0.001% of the RfD. It is concluded that (1) exposures to the most commonly detected pesticides on the twelve commodities pose negligible risks to consumers, (2) substitution of organic forms of the twelve commodities for conventional forms does not result in any appreciable reduction of consumer risks, and (3) the methodology used by the environmental advocacy group to rank commodities with respect to pesticide risks lacks scientific credibility.


Food and Chemical Toxicology | 2012

Comparison of acrylamide intake from Western and guideline based diets using probabilistic techniques and linear programming

Josh M. Katz; Carl K. Winter; Samuel E. Buttrey; J.G. Fadel

Western and guideline based diets were compared to determine if dietary improvements resulting from following dietary guidelines reduce acrylamide intake. Acrylamide forms in heat treated foods and is a human neurotoxin and animal carcinogen. Acrylamide intake from the Western diet was estimated with probabilistic techniques using teenage (13-19 years) National Health and Nutrition Examination Survey (NHANES) food consumption estimates combined with FDA data on the levels of acrylamide in a large number of foods. Guideline based diets were derived from NHANES data using linear programming techniques to comport to recommendations from the Dietary Guidelines for Americans, 2005. Whereas the guideline based diets were more properly balanced and rich in consumption of fruits, vegetables, and other dietary components than the Western diets, acrylamide intake (mean±SE) was significantly greater (P<0.001) from consumption of the guideline based diets (0.508±0.003 μg/kg/day) than from consumption of the Western diets (0.441±0.003 μg/kg/day). Guideline based diets contained less acrylamide contributed by French fries and potato chips than Western diets. Overall acrylamide intake, however, was higher in guideline based diets as a result of more frequent breakfast cereal intake. This is believed to be the first example of a risk assessment that combines probabilistic techniques with linear programming and results demonstrate that linear programming techniques can be used to model specific diets for the assessment of toxicological and nutritional dietary components.


Toxicology | 2002

Electronic information resources for food toxicology

Carl K. Winter

This manuscript provides a brief overview of many useful Internet resources concerning food toxicology. Specific topic areas include pesticide residues, food additives, natural toxins, environmental contaminants, and food allergies; numerous links and evaluative information are provided within each topic area. Several helpful Internet resources have been identified and include government, industry, academic, and consumer sites.


Comprehensive Reviews in Food Science and Food Safety | 2015

Diacetyl in Foods: A Review of Safety and Sensory Characteristics

Stephanie Clark; Carl K. Winter

Diacetyl, noted for its appealing butter-like aroma, is present naturally in many foods, and humans have been exposed to it since the beginning of civilization. The advent of microwave (MW) cooking technology has led to the development of a significant market for MW popcorn, to which diacetyl and other flavoring compounds have been frequently added. Based upon reported associations between diacetyl inhalation and lung disease in employees of MW popcorn processing facilities, a very conservative safe level of occupational exposure to diacetyl has been proposed by the American Conference of Governmental Industrial Hygienists. Yet there is conflicting evidence that diacetyl causes lung disease in workers, and no evidence to condemn diacetyl as the cause of lung problems in MW popcorn consumers. Consumer dietary exposure to diacetyl in foods is below levels of health concern while common airborne levels of diacetyl from MW popcorn are far below the conservatively established limit to protect workers.


Journal of Integrative Agriculture | 2015

Pesticide food safety standards as companions to tolerances and maximum residue limits

Carl K. Winter; Elizabeth A Jara

Allowable levels for pesticide residues in foods,known as tolerances in the US and as maximum residue limits(MRLs) in much of the world,are widely yet inappropriately perceived as levels of safety concern. A novel approach to develop scientifically defensible levels of safety concern is presented and an example to determine acute and chronic pesticide food safety standard(PFSS) levels for the fungicide captan on strawberries is provided. Using this approach,the chronic PFSS level for captan on strawberries was determined to be 2 000 mg kg–1 and the acute PFSS level was determined to be 250 mg kg–1. Both levels are far above the existing tolerance and MRLs that commonly range from 3 to 20 mg kg–1,and provide evidence that captan residues detected at levels greater than the tolerance or MRLs are not of acute or chronic health concern even though they represent violative residues. The benefits of developing the PFSS approach to serve as a companion to existing tolerances/MRLs include a greater understanding concerning the health significance,if any,from exposure to violative pesticide residues. In addition,the PFSS approach can be universally applied to all potential pesticide residues on all food commodities,can be modified by specific jurisdictions to take into account differences in food consumption practices,and can help prioritize food residue monitoring by identifying the pesticide/commodity combinations of the greatest potential food safety concern and guiding development of field level analytical methods to detect pesticide residues on prioritized pesticide/commodity combinations.


Mycopathologia | 1997

Characterization of epoxide hydrolase activity in Alternaria alternata f. sp. lycopersici. Possible involvement in toxin production : Epoxide hydrolase in Alternaria alternata f. sp. lycopersici

Franck Pinot; Eloisa Dutra Caldas; Christina Schmidt; David G. Gilchrist; A. D. Jones; Carl K. Winter; Bruce D. Hammock

Using trans-diphenylpropane oxide (tDPPO) as a substrate, we measured epoxide hydrolase (EH) activity in subcellular fractions of Alternaria alternata f. sp. lycopersici (Aal), a fungus that produces host-specific toxins. The activity was mainly (>99.5%) located in the soluble fraction (100,000 × g supernatant) with the optimum pH at 7.4. An increase of toxin production between days 3 and 9 found in a Aal liquid culture over a 15 days period was concomitant with a period of high EH activity. EH activity remained constant during the same period in an Alternaria alternata culture, a fungus which does not produce toxin. In vivo treatment of Aal culture with the peroxisome proliferator clofibrate stimulated EH activity by 83% and enhanced toxin production 6.3 fold. Both 4-fluorochalcone oxide (4-FCO) and (2S,3S)-(-)-3-(4-nitrophenyl)-glycidol (SS-NPG) inhibited EH activity in vitro with a IM50f 23 ± 1 μM and 72 ± 19 μM, respectively. The possible physiological substrate 9,10-epoxystearic acid was hydrolyzed more efficiently by Aal sEH than the model substrates trans- and cis-stilbene oxide (TSO and CSO) and trans- and cis-diphenylpropane oxide (tDPPO and cDPPO).Using trans-diphenylpropane oxide (tDPPO) as a substrate, we measured epoxide hydrolase (EH) activity in subcellular fractions of Alternaria alternata f. sp. lycopersici (Aal), a fungus that produces host-specific toxins. The activity was mainly (>99.5%) located in the soluble fraction (100,000 × g supernatant) with the optimum pH at 7.4. An increase of toxin production between days 3 and 9 found in a Aal liquid culture over a 15 days period was concomitant with a period of high EH activity. EH activity remained constant during the same period in an Alternaria alternata culture, a fungus which does not produce toxin. In vivo treatment of Aal culture with the peroxisome proliferator clofibrate stimulated EH activity by 83% and enhanced toxin production 6.3 fold. Both 4-fluorochalcone oxide (4-FCO) and (2S,3S)-(-)-3-(4-nitrophenyl)-glycidol (SS-NPG) inhibited EH activity in vitro with a IM50f 23 ± 1 μM and 72 ± 19 μM, respectively. The possible physiological substrate 9,10-epoxystearic acid was hydrolyzed more efficiently by Aal sEH than the model substrates trans- and cis-stilbene oxide (TSO and CSO) and trans- and cis-diphenylpropane oxide (tDPPO and cDPPO).


International Journal of Food Contamination | 2014

Dietary exposure to total and inorganic arsenic in the United States, 2006–2008

Elizabeth A Jara; Carl K. Winter

BackgroundConsumers are frequently exposed to arsenic in foods and considerable public and scientific concern exists regarding the potential health risks from dietary arsenic. Arsenic exists in both organic and inorganic forms and health effects are primarily attributed to inorganic forms. The most common analytical methods used to detect arsenic measure total arsenic, which includes both organic and inorganic forms. It is therefore necessary to make assumptions concerning the amounts of total arsenic found in food samples that represent inorganic arsenic. This work presents a new assessment of US dietary exposure to arsenic using data available from the FDA Total Diet Study from 2006-2008 and a series of scenarios developed to estimate inorganic arsenic levels.ResultsTotal arsenic exposures were estimated for 16 population subgroups and ranged from 1.4 x10-1 to 4.5 x10-1 µg/kg/day. The population subgroup with the highest exposure to total arsenic was 2 year-old children. The major food group contributors to total arsenic exposure for the general US population were marine sources, which accounted for 69 percent of the total arsenic exposure, and grains, legumes and seeds, which accounted for 20 percent. The highest inorganic arsenic exposures occurred for 2 year-old children and ranged from to 1.1 x10-1 µg/kg/day to 2.4 x10-1 µg/kg/day. Inorganic arsenic exposures for the 2 year-olds were 3.3 to 4.8 times higher than inorganic arsenic exposures for the general population. Under Scenario 5, which assumed that 70 percent of total arsenic from terrestrial sources and 10 percent of total arsenic from marine sources existed as inorganic arsenic, the most important food group contributors to inorganic arsenic for 2 years-olds were grains, legumes and seeds (50 percent), beverages (14 percent), marine sources (13 percent) and snacks and breakfast cereals (12 percent).ConclusionsThe exposures estimates obtained in this work are below the EPA’s established RfD of 0.3 µg/kg/day for inorganic arsenic and below EFSA’s health concern level of 0.3 to 8.0 µg/kg/day. To improve the accuracy of future arsenic risk assessments, studies should incorporate specific analytical data measuring inorganic arsenic from foods contributing the most to inorganic arsenic exposure.

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A. Daniel Jones

Michigan State University

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Josh M. Katz

University of California

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Barney Ward

University of California

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A. D. Jones

University of California

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Betty J. Burri

University of California

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