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Dive into the research topics where Carl-Magnus A. Andersson is active.

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Featured researches published by Carl-Magnus A. Andersson.


Tetrahedron Letters | 2000

Microwave-assisted solvent-free parallel synthesis of thioamides

Roger Olsson; Henrik C. Hansen; Carl-Magnus A. Andersson

Abstract Rapid parallel synthesis of thioamides is described. A library of amides, synthesised by mixing acyl chlorides and diamines, was transformed into the corresponding thioamides utilising Lawessons reagent as the oxygen/sulphur exchange reagent. Purification by solid-phase extraction afforded the library members in adequate purities and yields.


Tetrahedron Letters | 2001

General combinatorial synthesis of tertiary amines on solid support. A novel conditional release strategy based on traceless linking at nitrogen

Magnus Gustafsson; Roger Olsson; Carl-Magnus A. Andersson

Abstract A novel solid phase synthesis of tertiary amines involving iodide-induced cleavage of the N O bond of resin bound alkoxyammonium intermediates is described. The quaternary intermediates were assembled via sequential reductive aminations followed by alkylation. Cleavage from the solid support was induced by iodide ion or base, to afford the target tertiary amines in excellent purity.


Bioorganic & Medicinal Chemistry Letters | 2000

Multistep solution-phase parallel synthesis of spiperone analogues.

Henrik C. Hansen; Roger Olsson; Glenn Croston; Carl-Magnus A. Andersson

A flexible, multistep parallel synthesis of spiperone analogues is described. A library of 4-substituted piperidines, assembled utilizing reductive amination and acylation protocols, was alkylated either homogeneously or heterogeneously, exploiting a product release only concept, to afford an oxa-series of spiperone analogues. Screening of the products at 5-HT2 and D2 receptors revealed 5-HT2A antagonists with improved selectivity compared to spiperone and AMI-193.


Archive | 2004

Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases

David M. Weiner; Robert E. Davis; Mark R. Brann; Carl-Magnus A. Andersson; Allan K. Uldam


Archive | 2003

N-substituted piperidine derivatives as serotonin receptor agents

Carl-Magnus A. Andersson; Nathalie Schlienger; Alma Fejzic; Eva Louise Hansen; Jan Pawlas


Archive | 2001

Azacyclic compounds for use in the treatment of serotonin related diseases

Carl-Magnus A. Andersson; Glenn Croston; Eva-Louise Hansen; Allan K. Uldam


Archive | 2005

Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

Mikkel Boas Thygesen; Nathalie Schlienger; Bo-Ragnar Tolf; Carl-Magnus A. Andersson; Fritz Blatter; Jörg Berghausen


Archive | 2008

N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

Mikkel Boas Thygesen; Nathalie Schlienger; Bo-Ragnar Tolf; Carl-Magnus A. Andersson; Fritz Blatter; Jörg Berghausen


Archive | 2000

Solid phase parallel synthesis of tertiary amines

Carl-Magnus A. Andersson; Magnus Gustafsson; Kent R. I. Olsson


Archive | 2011

Methods of treatment using selective 5-ht2a inverse agonists

Carl-Magnus A. Andersson; Glenn Croston; Eva Louise Hansen; Allan K. Uldam

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Allan K. Uldam

ACADIA Pharmaceuticals Inc.

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Bo-Ragnar Tolf

ACADIA Pharmaceuticals Inc.

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Jörg Berghausen

ACADIA Pharmaceuticals Inc.

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Norman Nash

ACADIA Pharmaceuticals Inc.

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Fritz Blatter

Ciba Specialty Chemicals

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