Carl Ouellet
Bristol-Myers Squibb
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Publication
Featured researches published by Carl Ouellet.
Bioorganic & Medicinal Chemistry | 2001
Anne Marinier; Alain Martel; Carol Bachand; Serge Plamondon; Brigitte Turmel; Jean-Paul Daris; Jacques Banville; Philippe Lapointe; Carl Ouellet; Pierre Dextraze; Marcel Menard; John J Wright; Julie Alford; Debbie Lee; Paul L. Stanley; Xina Nair; Gordon Todderud; Kenneth M. Tramposch
A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111. On the other hand, the 4- and 6-hydroxy groups on the galactose ring are arranged to chelate the calcium ion in the P-selectin active site. The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl Lewis X are identified.
Journal of Medicinal Chemistry | 2005
Mark D. Wittman; Joan M. Carboni; Ricardo M. Attar; Balu Balasubramanian; Praveen Balimane; Patrick Brassil; Francis Beaulieu; Chiehying Chang; Wendy Clarke; Janet Dell; Jeffrey Eummer; David B. Frennesson; Marco M. Gottardis; Ann Greer; Steven Hansel; Warren Hurlburt; Bruce L. Jacobson; Subramaniam Krishnananthan; Francis Y. Lee; Aixin Li; Tai-An Lin; Peiying Liu; Carl Ouellet; Xiaopeng Sang; Mark G. Saulnier; Karen Stoffan; Yax Sun; Upender Velaparthi; Henry Wong; Zheng Yang
Journal of Virology | 1997
Guangxiang Luo; A. Torri; William E. Harte; Stephanie Danetz; Christopher Cianci; Laurence Tiley; Susan H. Day; David Mullaney; Kuo Long Yu; Carl Ouellet; Pierre Dextraze; Nicholas A. Meanwell; Richard J. Colonno; Mark Krystal
Bioorganic & Medicinal Chemistry Letters | 2007
Francis Beaulieu; Carl Ouellet; Edward H. Ruediger; Makonen Belema; Yuping Qiu; Xuejie Yang; Jacques Banville; James R. Burke; Kurt R. Gregor; John F. MacMaster; Alain Martel; Kim W. McIntyre; Mark A. Pattoli; F. Christopher Zusi; Dolatrai M. Vyas
Bioorganic & Medicinal Chemistry Letters | 2007
Makonen Belema; Amy Bunker; Van N. Nguyen; Francis Beaulieu; Carl Ouellet; Yuping Qiu; Yunhui Zhang; Alain Martel; James R. Burke; Kim W. McIntyre; Mark A. Pattoli; Connie Daloisio; Kathleen M. Gillooly; Wendy Clarke; Patrick J. Brassil; F. Chris Zusi; Dolatrai M. Vyas
Archive | 2005
B. Narasimhulu Naidu; Jacques Banville; Francis Beaulieu; Timothy P. Connolly; Mark Krystal; John D. Matiskella; Carl Ouellet; Serge Plamondon; Roger Remillard; Margaret E. Sorenson; Yasutsugu Ueda; Michael A. Walker
Archive | 2003
Makonen Belema; Amy Bunker; Van N. Nguyen; Francis Beaulieu; Carl Ouellet; Anne Marinier; Stephan Roy; Xuejie Yang; Yuping Qiu; Yunhui Zhang; Alain Martel; Christopher Zusi
Archive | 2001
Francis Beaulieu; Carl Ouellet; Makonen Belema; Yuping Qiu; Xuejie Yang; Fred Christopher Zusi
Archive | 2009
Francis Beaulieu; Carl Ouellet; B. Narasimhulu Naidu; Manoj Patel; Yasutsugu Ueda; Timothy P. Connolly; Jonathan R. Weiss; Michael A. Walker; Nicholas A. Meanwell; Kevin Peese; Margaret E. Sorenson
Archive | 2003
Makonen Belema; Amy Bunker; Van N. Nguyen; Francis Beaulieu; Carl Ouellet; Anne Marinier; Stephan Roy; Xuejie Yang; Yuping Qiu; Yunhui Zhang; Alain Martel; Christopher Zusi
