Is this you? Create Your Porfile
Avatar

Francis Beaulieu

Bristol-Myers Squibb

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Francis Beaulieu is active.

Explore More

Publication

Featured researches published by Francis Beaulieu.

Bioorganic & Medicinal Chemistry Letters | 2015

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors

B. Narasimhulu Naidu; Margaret E. Sorenson; Manoj Patel; Yasutsugu Ueda; Jacques Banville; Francis Beaulieu; Sagarika Bollini; Ira B. Dicker; Helen Higley; Zeyu Lin; Lori Pajor; Dawn D. Parker; Brian Terry; Ming Zheng; Alain Martel; Nicholas A. Meanwell; Mark Krystal; Michael A. Walker

Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.

Bioorganic & Medicinal Chemistry Letters | 2016

Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors.

Brent Richard Stranix; Jinzi J. Wu; Guy Milot; Francis Beaulieu; Jean-Emanuel Bouchard; Kristine Gouveia; André J. Forté; Seema Garde; Zhigang Wang; Jean-François Mouscadet; Olivier Delelis; Yong Xiao

A series of pyridoxine hydroxamic acid analog bearing a 5-aryl-spacers were synthesized. Evaluation of these novel HIV integrase complex inhibitors revealed compounds with high potency against wild-type HIV virus.

Journal of Medicinal Chemistry | 2005

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

Mark D. Wittman; Joan M. Carboni; Ricardo M. Attar; Balu Balasubramanian; Praveen Balimane; Patrick Brassil; Francis Beaulieu; Chiehying Chang; Wendy Clarke; Janet Dell; Jeffrey Eummer; David B. Frennesson; Marco M. Gottardis; Ann Greer; Steven Hansel; Warren Hurlburt; Bruce L. Jacobson; Subramaniam Krishnananthan; Francis Y. Lee; Aixin Li; Tai-An Lin; Peiying Liu; Carl Ouellet; Xiaopeng Sang; Mark G. Saulnier; Karen Stoffan; Yax Sun; Upender Velaparthi; Henry Wong; Zheng Yang

Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors

Francis Beaulieu; Carl Ouellet; Edward H. Ruediger; Makonen Belema; Yuping Qiu; Xuejie Yang; Jacques Banville; James R. Burke; Kurt R. Gregor; John F. MacMaster; Alain Martel; Kim W. McIntyre; Mark A. Pattoli; F. Christopher Zusi; Dolatrai M. Vyas

Bioorganic & Medicinal Chemistry Letters | 2007

Synthesis and structure-activity relationship of imidazo (1,2 -a )thieno (3,2 -e )pyrazines as IKK-β inhibitors

Makonen Belema; Amy Bunker; Van N. Nguyen; Francis Beaulieu; Carl Ouellet; Yuping Qiu; Yunhui Zhang; Alain Martel; James R. Burke; Kim W. McIntyre; Mark A. Pattoli; Connie Daloisio; Kathleen M. Gillooly; Wendy Clarke; Patrick J. Brassil; F. Chris Zusi; Dolatrai M. Vyas

Journal of Medicinal Chemistry | 2005

Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11†

Mark G. Saulnier; Balu Balasubramanian; Byron H. Long; David B. Frennesson; Edward H. Ruediger; Kurt Zimmermann; Jeffrey Eummer; Denis R. St. Laurent; Karen Stoffan; B. Narasimhulu Naidu; Mikael Mahler; Francis Beaulieu; Carol Bachand; Frank Y. Lee; Craig R. Fairchild; Linda K. Stadnick; William C. Rose; Carola Solomon; Henry Wong; Alain Martel; John J. Wright; Robert Kramer; David R. Langley; Dolatrai M. Vyas

Archive | 2005

Bicyclic heterocycles as hiv integrase inhibitors

B. Narasimhulu Naidu; Jacques Banville; Francis Beaulieu; Timothy P. Connolly; Mark Krystal; John D. Matiskella; Carl Ouellet; Serge Plamondon; Roger Remillard; Margaret E. Sorenson; Yasutsugu Ueda; Michael A. Walker

Journal of Medicinal Chemistry | 2004

Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with Curative Antitumor Activity against Prostate Carcinoma Xenograft Tumor Model§

Balu Balasubramanian; Denis R. St. Laurent; Mark G. Saulnier; Byron H. Long; Carol Bachand; Francis Beaulieu; Wendy Clarke; Milind Deshpande; Jeffrey Eummer; Craig R. Fairchild; David B. Frennesson; Robert Kramer; Frank Y. Lee; Mikael Mahler; Alain Martel; B. Narasimhulu Naidu; William C. Rose; John W. Russell; Edward H. Ruediger; Carola Solomon; Karen Stoffan; Henry Wong; Kurt Zimmermann; Dolatrai M. Vyas

Archive | 2003

Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same

Makonen Belema; Amy Bunker; Van N. Nguyen; Francis Beaulieu; Carl Ouellet; Anne Marinier; Stephan Roy; Xuejie Yang; Yuping Qiu; Yunhui Zhang; Alain Martel; Christopher Zusi

Archive | 2001

AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Francis Beaulieu; Carl Ouellet; Makonen Belema; Yuping Qiu; Xuejie Yang; Fred Christopher Zusi

Explore More

Collaboration

Dive into the Francis Beaulieu's collaboration.

Top Co-Authors
Avatar

Carl Ouellet

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Makonen Belema

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Alain Martel

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

B. Narasimhulu Naidu

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Yuping Qiu

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Xuejie Yang

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Edward H. Ruediger

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Michael A. Walker

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Yasutsugu Ueda

Bristol-Myers Squibb

View shared research outputs
Top Co-Authors
Avatar

Carol Bachand

Bristol-Myers Squibb

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge