Catherine Ott
BioMérieux
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Publication
Featured researches published by Catherine Ott.
Biological Chemistry | 2006
Nathalie Heuzé-Vourc'h; Mireille Ainciburu; Chris Planque; Michèle Brillard-Bourdet; Catherine Ott; Colette Jolivet-Reynaud; Yves Courty
Abstract Kallikreins have been implicated in carcinogenesis and are promising biomarkers for the diagnosis and follow-up of various cancers. To evaluate the functions and clinical interest of kallikreins, it is important to be able to produce them as recombinant proteins. Here we summarize the various strategies used to produce kallikreins, emphasizing their advantages and limitations. We also describe an approach to achieve high-level production of kallikreins, such as hK6, with correct folding and activity, combining an expression system with targeted transgene integration and an efficient cultivation device to increase yield, the CELLine bioreactor. This novel method for recombinant kallikrein production will be useful to study their bio-pathological functions and to develop anti-bodies.
Biological Chemistry | 2014
Catherine Ott; Mireille Ainciburu; Christelle Parent; Sandrine Michel; Céline Roesch; Patrick Vourc’h; Philippe Corcia; Nathalie Heuzé-Vourc’h; Colette Jolivet-Reynaud; Yves Courty
Abstract We have raised monoclonal antibodies against KLK6 and constructed a ‘sandwich’ type immunoassay using 8A8G3 as capture and 3H3E9 as tracer antibodies. 8A8G3 bound to one side of KLK6, whereas 3H3E9 probably bound near its catalytic site. The assay did not detect complexed forms of KLK6, indicating that it quantifies only free KLK6 (fKLK6). fKLK6 was higher in serum of patients with ovarian cancer (11.34 μg/l±1.37) than in controls (3.39 μg/l±0.42). The cerebrospinal fluid contained high concentrations of fKLK6 (257–965 μg/l). This assay could facilitate the evaluation of fKLK6 in human diseases.
Diabetologia | 2014
Hala Aswad; Alexis Forterre; Oscar P. B. Wiklander; Guillaume Vial; Emmanuelle Danty-Berger; Audrey Jalabert; Antonin Lamazière; Sandra Pesenti; Catherine Ott; Karim Chikh; Samir El-Andaloussi; Hubert Vidal; Etienne Lefai; Jennifer Rieusset; Sophie Rome
Journal of Molecular Biology | 2011
Bruno H. Muller; Alexandra Savatier; Guillaume L'Hostis; Narciso Costa; Marc Bossus; Sandrine Michel; Catherine Ott; Laurence Becquart; Alain Ruffion; Enrico A. Stura; Frédéric Ducancel
Archive | 1998
Glaucia Paranhos-Baccala; Florence Komurian-Pradel; Frederic Bedin; Mireille Sodoyer; Catherine Ott; François Mallet; Hervé Perron; Bernard Mandrand
Archive | 2016
Catherine Ott; François Mallet; Laurence Generenaz
Archive | 2013
Yasemin Ataman-Önal; Geneviève Choquet-Kastylevsky; Hader Haidous; Sandrine Michel-Busseret; Catherine Ott
Archive | 2010
Glaucia Paranhos-Baccala; Florence Komurian-Pradel; Frederic Bedin; Mireille Sodoyer; Catherine Ott; François Mallet; Hervé Perron; Bernard Mandrand
Medecine Nucleaire-imagerie Fonctionnelle Et Metabolique | 2008
Colette Jolivet-Reynaud; Sandrine Michel; Catherine Ott
Archive | 1998
Glaucia Parahnos-Baccala; Florence Komurian-Pradel; Frederic Bedin; Mireille Sodoyer; Catherine Ott; Hervé Perron; Bernard Mandrand; François Mallet