Cécile Delcourt

Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes.

The molecular recognition of human telomeric G-quadruplexes by a novel cationic π-extended Ni(II)-porphyrin (Ni(II)-TImidP4) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted Ni(II)-porphyrin (Ni(II)-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of Ni(II)-TImidP4 towards human telomeric G4 than that of Ni(II)-TMPyP4.

Macrocyclic regioregular poly(3-hexylthiophene): from controlled synthesis to nanotubular assemblies

An easy and quantitative cyclization procedure based on an intramolecular imperfect aldol reaction from a pre-generated regioregular poly(3-hexylthiophene) is developed. As an illustration of the versatility of this procedure, the synthesis of a representative macrocyclic poly(3-hexylthiophene) with a diameter of 5 nm is presented.