Chae Man Lim
Asan Medical Center
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Publication
Featured researches published by Chae Man Lim.
Journal of Korean Medical Science | 2014
Youjin Chang; So Hee Park; Jin Won Huh; Chae Man Lim; Younsuck Koh; Sang-Bum Hong
Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary fibrosis. He received a long period of mechanical ventilation and weaning proved difficult. On hospital day 114, he underwent the intratracheal administration of UCB-derived MSCs at a dose of 1 × 106/kg. After cell infusion, an immediate improvement was shown in his mental status, his lung compliance (from 22.7 mL/cmH2O to 27.9 mL/cmH2O), PaO2/FiO2 ratio (from 191 mmHg to 334 mmHg) and his chest radiography over the course of three days. Even though he finally died of repeated pulmonary infection, our current findings suggest the possibility of using MSCs therapy in an ARDS patient. It is the first clinical case of UCB-derived MSCs therapy ever reported.
Academic Emergency Medicine | 2013
Chang Hwan Sohn; Seung Mok Ryoo; Ji Young Yoon; Dong Woo Seo; Kyoung Soo Lim; Sung-Han Kim; Sang-Bum Hong; Chae Man Lim; Younsuck Koh; Won Young Kim
OBJECTIVES A novel swine-origin influenza A (H1N1) virus caused worldwide outbreaks starting in April 2009. The aim of this study was to evaluate the clinical characteristics and outcomes of pandemic 2009 H1N1 pneumonia by comparing to community-acquired pneumonia (CAP) of other origin. METHODS The authors conducted a prospective cohort study of consecutive adult (over 15 years old) patients with suspected CAP requiring admission to a tertiary university-affiliated hospital during the second wave of pandemic 2009 H1N1 influenza. Based on the results of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis, the staff completed a standard assessment form and managed the patients according to a uniform protocol. Clinical characteristics, as well as laboratory and radiologic findings, were collected and compared between pandemic 2009 H1N1 pneumonia and CAP of other origin. The primary outcome was in-hospital mortality and secondary outcomes were duration of hospitalization, duration of intensive care unit (ICU) stay, and requirement of mechanical ventilation. RESULTS A total of 135 patients with suspected CAP were included in the study. Of these, 59 patients were RT-PCR positive for H1N1 virus, and 76 patients were RT-PCR negative. Patients with H1N1 pneumonia were significantly younger than those with CAP of other origin (46.0 years vs. 68.0 years, p < 0.01) and more frequently had nonspecific symptoms (p < 0.01), initial leukopenia (8.5% vs. 0.0%, p = 0.01), lymphopenia (45.8% vs. 26.3%, p = 0.02), low values of C-reactive protein (CRP; 5.2 mg/dL vs. 13.4 mg/dL, p = 0.02), bilateral abnormalities (57.7% vs. 29.7%, p < 0.01) on chest radiography, ground glass opacities (43.9% vs. 12.8%, p < 0.01) on chest computed tomography, and low values of pneumonia severity index (PSI) score (56.0 vs. 91.0, p < 0.01) than those with CAP of other origin. However, there were no significant differences in infection severity, clinical outcome, length of ICU stay, requirement for mechanical ventilation, and mortality between the two groups. CONCLUSIONS This study shows that clinical characteristics and outcomes of 2009 H1N1 pneumonia are comparable to those of CAP of other origin. However, some characteristics, including younger age, nonspecific symptoms (including headache, leukopenia, and fatigue), lymphopenia, lower initial CRP and PSI score, and radiologic findings (including bilateral abnormalities and ground glass opacities), may help clinicians to diagnostically differentiate between H1N1 pneumonia and CAP of other origin before the result of RT-PCR are obtained.
Tuberculosis and Respiratory Diseases | 2002
Jin Won Huh; Chae Man Lim; Yang Jin Jegal; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Won Dong Kim; Younsuck Koh
Tuberculosis and Respiratory Diseases | 1998
Sang-Bum Hong; Woo Sung Kim; Jae Hwan Lee; Sung Jo Bang; Tae Son Shim; Chae Man Lim; Sang Do Lee; Younsuck Koh; In Chul Lee; Dong Soon Kim; Won Dong Kim
Tuberculosis and Respiratory Diseases | 1999
Doo Seop Moon; Chae Man Lim; Chik Hyun Pai; Mi Na Kim; Jae Yong Chin; Tae Sun Shim; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Won Dong Kim; Younsuck Koh
Tuberculosis and Respiratory Diseases | 1997
Jang Won Sohn; Younsuck Koh; Chae Man Lim; Jong Deog Lee; Tae Sun Shim; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Won Dong Kim
Tuberculosis and Respiratory Diseases | 1996
Younsuck Koh; Brooks M Hybertson; Eric K Jepson; Mi Jung Kim; In Chul Lee; Chae Man Lim; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Won Dong Kim; John E Repine
Tuberculosis and Respiratory Diseases | 1995
Chae Man Lim; Jae Kyun Lee; Sung Soon Lee; Younsuck Koh; Woo Sung Kim; Dong Soon Kim; Won Dong Kim; Pyung Hwan Park; Jong Moo Choi
Tuberculosis and Respiratory Diseases | 1999
Joo Hun Park; Hee Bom Moon; Joo Ock Na; Hun Ho Song; Chae Man Lim; Moo Song Lee; Tae Sun Shim; Sang Do Lee; Woo Sung Kim; Dong Soon Kim; Won Dong Kim; Younsuck Koh
Tuberculosis and Respiratory Diseases | 1996
Won Kyoung Cho; Chae Man Lim; Sang Do Lee; Younsuck Koh; Woo Sung Kim; Eun Sil Yoo; Dong Soon Kim; Won Dong Kim