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Chandravadan R. Shah

Johnson & Johnson Pharmaceutical Research and Development

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Publication

Featured researches published by Chandravadan R. Shah.

Bioorganic & Medicinal Chemistry Letters | 2010

Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.

Emily M. Stocking; Leah Aluisio; John R. Atack; Pascal Bonaventure; Nicholas I. Carruthers; Christine Dugovic; Anita Everson; Ian C. Fraser; Xiaohui Jiang; Perry Leung; Brian Lord; Kiev S. Ly; Kirsten L. Morton; Diane Nepomuceno; Chandravadan R. Shah; Jonathan Shelton; Akinola Soyode-Johnson; Michael A. Letavic

Pre-clinical characterization of novel substituted pyrrolidines that are high affinity histamine H(3) receptor antagonists is described. These compounds efficiently penetrate the CNS and occupy the histamine H(3) receptor in rat brain following oral administration. One compound, (2S,4R)-1-[2-(4-cyclobutyl-[1,4]diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-yl]-ethanone, was extensively profiled and shows promise as a potential clinical candidate.

Archive | 2004

Phenyl-substituted imidazopyridines

J. Guy Breitenbucher; Nicholas I. Carruthers; Xiaobing Li; Laura C. Mcatee; Chandravadan R. Shah; Ronald L. Wolin

Archive | 2001

Non-imidazole aryloxypiperidines

Richard Apodaca; Nicholas I. Carruthers; Curt A. Dvorak; Chandravadan R. Shah; Wei Xiao

Archive | 2001

Non-imidazole aryloxyalkylamines as h3 receptor ligands

Richard Apodaca; Nicholas I. Carruthers; Curt A. Dvorak; Dale A. Rudolph; Chandravadan R. Shah; Wei Xiao

Archive | 2003

Piperazinyl and diazapanyl benzamides and benzthioamides

Richard Apodaca; Jill A. Jablonowski; Kiev S. Ly; Chandravadan R. Shah; Devin M. Swanson; Wei Xiao

Archive | 2005

Non-imidazole heterocyclic compounds

Nicholas I. Carruthers; Chandravadan R. Shah; Devin M. Swanson

Archive | 2003

(1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders

Nicholas I. Carruthers; Curt A. Dvorak; James P. Edwards; Cheryl A. Grice; Jill A. Jablonowski; Kiev S. Ly; Barbara Pio; Chandravadan R. Shah; Jennifer D. Venable

Archive | 2001

Octahydro-indolizines and quinolizines and hexahydro-pyrrolizines

Richard Apodaca; Nicholas I. Carruthers; John R. Carson; Wenying Chai; Annette K. Kwok; Xiaobing Li; Timothy W. Lovenberg; Dale A. Rudolph; Chandravadan R. Shah

Archive | 2006

Non-imidazole aryloxyalkylamines

Richard Apodaca; Nicholas I. Carruthers; Curt A. Dvorak; Dale A. Rudolph; Chandravadan R. Shah; Wei Xiao

Archive | 2007

Indoles and benzoimidazoles as histamine H4 receptor modulators

James P. Edwards; Brad M. Savall; Chandravadan R. Shah

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Nicholas I. Carruthers

Johnson

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Devin M. Swanson

Johnson

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Michael A. Letavic

Harvard University

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Daniel J. Pippel

Urbana University

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Brock T. Shireman

Janssen Pharmaceutica

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Timothy W. Lovenberg

Janssen Pharmaceutica

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Cheryl A. Grice

Schering-Plough

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John R. Carson

Johnson

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Lars Karlsson

Scripps Research Institute

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Neelakandha S. Mani

Colorado State University

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