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Dive into the research topics where Chaoyu Xie is active.

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Featured researches published by Chaoyu Xie.


Synthetic Communications | 2007

Selective Monoarylation of Benzenediols via Dianion Intermediates

Chaoyu Xie; Kevin A. Sullivan; Michael E. Laurila; David Mitchell; Y.John Pu

Abstract Application of the SNAr reaction on benzenediols with arylfluorides revealed an enhancement in monosubstitution selectivity over bis substitution when excess base was used. This trend was studied using symmetrical and nonsymmetrical benzenediols with various levels of steric hindrance. The effect of various bases was examined. A 100% monoselectivity was achieved in the presence of 2.5 equiv. of Cs2CO3. The methodology was employed in the synthesis of an important pharmaceutical product, 1, an arylether.


Archive | 2002

Piperazine- and piperidine-derivatives as melanocortin receptor agonists

Karin Briner; Christopher William Doecke; Vincent Mancuso; Michael John Martinelli; Timothy I. Richardson; Roger Ryan Rothhaar; Qing Shi; Chaoyu Xie


Archive | 2002

Substituted piperidines/piperazines as melanocortin receptor agonists

Ryan T. Backer; Karin Briner; Christopher William Doecke; Matthew Joseph Fisher; Steven L. Kuklish; Vincent Mancuso; Michael J. Martinelli; Jeffrey Thomas Mullaney; Chaoyu Xie


Journal of Medicinal Chemistry | 2006

Design and synthesis of dual peroxisome proliferator-activated receptors γ and δ agonists as novel euglycemic agents with a reduced weight gain profile

Yanping Xu; Garret J. Etgen; Carol L. Broderick; Emily J. Canada; Isabel C. Gonzalez; Jason Lamar; Chahrzad Montrose-Rafizadeh; Brian A. Oldham; John Osborne; Chaoyu Xie; Qing Shi; Leonard L. Winneroski; Jeremy Schulenburg York; Nathan Yumibe; Richard W. Zink; Nathan Bryan Mantlo


Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor

Qing Shi; Paul L. Ornstein; Karin Briner; Timothy I. Richardson; Macklin Brian Arnold; Ryan T. Backer; Jennifer L. Buckmaster; Emily J. Canada; Christopher W. Doecke; Larry Wayne Hertel; Nick Honigschmidt; Hansen M. Hsiung; Saba Husain; Steve L. Kuklish; Michael J. Martinelli; Jeffrey Thomas Mullaney; Thomas P. O’Brien; Matt R. Reinhard; Roger Ryan Rothhaar; Jikesh Shah; Zhipei Wu; Chaoyu Xie; John M. Zgombick; Matthew Joseph Fisher


Organic Process Research & Development | 2011

Process Development for a Key Synthetic Intermediate of LY2140023, a Clinical Candidate for the Treatment of Schizophrenia

Mario Waser; Eric D. Moher; Sandy S. K. Borders; Marvin M. Hansen; David W. Hoard; Michael E. Laurila; Michael E. LeTourneau; Richard D. Miller; Michael L. Phillips; Kevin A. Sullivan; Jeffrey A. Ward; Chaoyu Xie; Cheryl A. Bye; Tanja Leitner; Brigitte Herzog-Krimbacher; Marcus Kordian; Martin Müllner


Organic Process Research & Development | 2005

Nucleosidic phosphoramidite synthesis via phosphitylation : Activator selection and process development

Chaoyu Xie; Michael A. Staszak; John Thomas Indianapolis Quatroche; Christa D. Sturgill; Vien V. Khau; Michael John Martinelli


Bioorganic & Medicinal Chemistry Letters | 2007

Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists

Qing Shi; Emily J. Canada; Yanping Xu; Alan M. Warshawsky; Garret J. Etgen; Carol L. Broderick; Cathleen K. Clutinger; Lynnie Irwin; Michael E. Laurila; Chahrzad Montrose-Rafizadeh; Brian A. Oldham; Minmin Wang; Leonard L. Winneroski; Chaoyu Xie; Jeremy Schulenburg York; Nathan Yumibe; Richard W. Zink; Nathan Bryan Mantlo


Archive | 2002

Piperazine derivatives as agonists of the melanocortin receptor

Kelly Christopher Biggers; Karin Briner; William Christopher Doecke; Joseph Matthew Fisher; Wayne Larry Hertel; Vincent Mancuso; John Michael Martinelli; Philip Mayer; Leslie Paul Ornstein; Ivo Timothy Richardson; Arvind Shah; Qing Shi; Zhipei Wu; Chaoyu Xie


Archive | 2002

Piperazinderivate als agonisten des melanocortin-rezeptors Piperazine derivatives as agonists of the melanocortin-receptor expression

Kelly Christopher Biggers; Karin Briner; William Christopher Doecke; Joseph Matthew Fisher; Wayne Larry Hertel; Vincent Mancuso; John Michael Martinelli; Philip Mayer; Leslie Paul Ornstein; Ivo Timothy Richardson; Arvind Shah; Qing Shi; Zhipei Wu; Chaoyu Xie

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Qing Shi

Eli Lilly and Company

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Zhipei Wu

Eli Lilly and Company

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