Charl P. Botha

Fast and reproducible fiber bundle selection in DTI visualization

Diffusion tensor imaging (DTI) is an MRI-based technique for quantifying water diffusion in living tissue. In the white matter of the brain, water diffuses more rapidly along the neuronal axons than in the perpendicular direction. By exploiting this phenomenon, DTI can be used to determine trajectories of fiber bundles, or neuronal connections between regions, in the brain. The resulting bundles can be visualized. However, the resulting visualizations can be complex and difficult to interpret. An effective approach is to pre-determine trajectories from a large number of positions throughout the white matter (full brain fiber tracking) and to offer facilities to aid the user in selecting fiber bundles of interest. Two factors are crucial for the use and acceptance of this technique in clinical studies: firstly, the selection of the bundles by brain experts should be interactive, supported by real-time visualization of the trajectories registered with anatomical MRI scans. Secondly, the fiber selections should be reproducible, so that different experts will achieve the same results. In this paper we present a practical technique for the interactive selection of fiber-bundles using multiple convex objects that is an order of magnitude faster than similar techniques published earlier. We also present the results of a clinical study with ten subjects that show that our selection approach is highly reproducible for fractional anisotropy (FA) calculated over the selected fiber bundles.

Piecewise laplacian-based projection for interactive data exploration and organization

Multidimensional projection has emerged as an important visualization tool in applications involving the visual analysis of high‐dimensional data. However, high precision projection methods are either computationally expensive or not flexible enough to enable feedback from user interaction into the projection process. A built‐in mechanism that dynamically adapts the projection based on direct user intervention would make the technique more useful for a larger range of applications and data sets. In this paper we propose the Piecewise Laplacian‐based Projection (PLP), a novel multidimensional projection technique, that, due to the local nature of its formulation, enables a versatile mechanism to interact with projected data and to allow interactive changes to alter the projection map dynamically, a capability unique of this technique. We exploit the flexibility provided by PLP in two interactive projection‐based applications, one designed to organize pictures visually and another to build music playlists. These applications illustrate the usefulness of PLP in handling high‐dimensional data in a flexible and highly visual way. We also compare PLP with the currently most promising projections in terms of precision and speed, showing that it performs very well also according to these quality criteria.

Lines of Curvature for Polyp Detection in Virtual Colonoscopy

Computer-aided diagnosis (CAD) is a helpful addition to laborious visual inspection for preselection of suspected colonic polyps in virtual colonoscopy. Most of the previous work on automatic polyp detection makes use of indicators based on the scalar curvature of the colon wall and can result in many false-positive detections. Our work tries to reduce the number of false-positive detections in the preselection of polyp candidates. Polyp surface shape can be characterized and visualized using lines of curvature. In this paper, we describe techniques for generating and rendering lines of curvature on surfaces and we show that these lines can be used as part of a polyp detection approach. We have adapted existing approaches on explicit triangular surface meshes, and developed a new algorithm on implicit surfaces embedded in 3D volume data. The visualization of shaded colonic surfaces can be enhanced by rendering the derived lines of curvature on these surfaces. Features strongly correlated with true-positive detections were calculated on lines of curvature and used for the polyp candidate selection. We studied the performance of these features on 5 data sets that included 331 pre-detected candidates, of which 50 sites were true polyps. The winding angle had a significant discriminating power for true-positive detections, which was demonstrated by a Wilcoxon rank sum test with p<0.001. The median winding angle and inter-quartile range (IQR) for true polyps were 7.817 and 6.770-9.288 compared to 2.954 and 1.995-3.749 for false-positive detections

Smooth Graphs for Visual Exploration of Higher-Order State Transitions

In this paper, we present a new visual way of exploring state sequences in large observational time-series. A key advantage of our method is that it can directly visualize higher-order state transitions. A standard first order state transition is a sequence of two states that are linked by a transition. A higher-order state transition is a sequence of three or more states where the sequence of participating states are linked together by consecutive first order state transitions. Our method extends the current state-graph exploration methods by employing a two dimensional graph, in which higher-order state transitions are visualized as curved lines. All transitions are bundled into thick splines, so that the thickness of an edge represents the frequency of instances. The bundling between two states takes into account the state transitions before and after the transition. This is done in such a way that it forms a continuous representation in which any subsequence of the timeseries is represented by a continuous smooth line. The edge bundles in these graphs can be explored interactively through our incremental selection algorithm. We demonstrate our method with an application in exploring labeled time-series data from a biological survey, where a clustering has assigned a single label to the data at each time-point. In these sequences, a large number of cyclic patterns occur, which in turn are linked to specific activities. We demonstrate how our method helps to find these cycles, and how the interactive selection process helps to find and investigate activities.

Interactive visualization of multi-field medical data using linked physical and feature-space views

Multi-field datasets contain multiple parameters defined over the same spatio-temporal domain. In medicine, such multi-field data is being used more often every day, and there is an urgent need for exploratory visualization approaches that are able to deal effectively with the data-analysis. In this paper, we present a highly interactive, coordinated view-based visualization approach that has been developed especially for dealing with multi-field medical data. It can show any number of views of the physical domain and also of the abstract high-dimensional feature space. The approach has been optimized for interactive use with very large datasets. It is based on intuitive interaction techniques, and integrates analysis techniques from pattern classification to guide the exploration process. We will give some details about the implementation, and we demonstrate the utility of our approach with two real medical use cases.

Integrated Support for Medical Image Analysis Methods: From Development to Clinical Application

Computer-aided image analysis is becoming increasingly important to efficiently and safely handle large amounts of high-resolution images generated by advanced medical imaging devices. The development of medical image analysis (MIA) software with the required properties for clinical application, however, is difficult and labor-intensive. Such development should be supported by systems providing scalable computational capacity and storage space, as well as information management facilities. This paper describes the properties of distributed systems to support and facilitate the development, evaluation, and clinical application of MIA methods. First, the main characteristics of existing systems are presented. Then, the phases in a methods lifecycle are analyzed (development, parameter optimization, evaluation, clinical routine), identifying the types of users, tasks, and related computational issues. A scenario is described where all tasks are performed with the aid of computational tools integrated into an ideal supporting environment. The requirements for this environment are described, proposing a grid-oriented paradigm that emphasizes virtual collaboration among users, pieces of software, and devices distributed among geographically dispersed healthcare, research, and development enterprises. Finally, the characteristics of the existing systems are analyzed according to these requirements. The proposed requirements offer a useful framework to evaluate, compare, and improve the existing systems that support MIA development

Dynamic multi-view exploration of shape spaces

Statistical shape modeling is a widely used technique for the representation and analysis of the shapes and shape variations present in a population. A statistical shape model models the distribution in a high dimensional shape space, where each shape is represented by a single point.

Articulated Planar Reformation for Change Visualization in Small Animal Imaging

The analysis of multi-timepoint whole-body small animal CT data is greatly complicated by the varying posture of the subject at different timepoints. Due to these variations, correctly relating and comparing corresponding regions of interest is challenging.In addition, occlusion may prevent effective visualization of these regions of interest. To address these problems, we have developed a method that fully automatically maps the data to a standardized layout of sub-volumes, based on an articulated atlas registration.We have dubbed this process articulated planar reformation, or APR. A sub-volume can be interactively selected for closer inspection and can be compared with the corresponding sub-volume at the other timepoints, employing a number of different comparative visualization approaches. We provide an additional tool that highlights possibly interesting areas based on the change of bone density between timepoints. Furthermore we allow visualization of the local registration error, to give an indication of the accuracy of the registration. We have evaluated our approach on a case that exhibits cancer-induced bone resorption.

PEx-WEB: Content-based Visualization of Web Search Results

The efficacy of search engines has expanded the uses for the information available on the Web. An increasing number of applications make use of the WWW as a primary source of information. The usefulness of such applications is, however, impaired by the current styles of display of the Web search results. This paper presents a system that adapts two techniques to map and explore Web results visually in order to find relevant patterns and relationships amongst the resulting documents. The first technique creates a visual map of the search results using a content-based multidimensional projection. The second techniques is capable of identifying, labeling and displaying topics within sub-groups of documents on the map. The system (The Projection explorer for the WWW, or PEx-Web) implements these techniques and various additional tools as means to make better use of Web search results for exploratory applications.

Integrated visualization of multi-angle bioluminescence imaging and micro CT

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.