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Dive into the research topics where Charles A. Dinarello is active.

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Featured researches published by Charles A. Dinarello.


Archive | 1995

A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production

Amy E. Chernoff; Eric V. Granowitz; Leland Shapiro; Edouard Vannier; Gerhard Lonnemann; Jonathan B. Angel; Scott F. Orencole; Jeffrey S. Kennedy; Xi-Xian Zhang; Hei-De Wen; Ellen C. Donaldson; Elaine Radwanski; David L. Cutler; Sheldon M. Wolff; Charles A. Dinarello

Interleukin-l0 (IL-10) has multiple in vitro actions on different cell types including thymocytes,1 T and B lymphocytes,2–4 monocytes,5 neu-trophils,6 and mast cells.7 When cultured with T lymphocytes, IL-10 suppresses IL-2 and IFN-γ production and inhibits mitogen-induced T-cell proliferation.8,9 On the other hand, IL-10 stimulates B-cell growth and immunoglobulin (Ig) production.4 In monocytes, IL-10 inhibits synthesis and gene expression for IL-1, TNF, IL-6, IL-8, and colony stimulating factors.5,8 Similar effects have been observed in neutrophils.6 IL-10 also prevents macrophage cytotoxic activity by inhibiting both cytokine and nitric oxide production.10


Archive | 1987

Recombinant DNA which codes for interleukin-1

Philip E. Auron; Charles A. Dinarello; Andrew C. Webb; Alexander Rich; Sheldon M. Wolff


Archive | 1985

Truncated protein of interleukin-1

Philip E. Auron; Andrew C. Webb; Lee Gehrke; Charles A. Dinarello; Lanny J. Rosenwasser; Alexander Rich; Sheldon M. Wolff


Archive | 1985

Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins

Philip E. Auron; Andrew C. Webb; Lee Gehrke; Charles A. Dinarello; Lanny Rosenwasser; Alexander Rich; Sheldon M. Wolff


Archive | 1988

IL-1βprotein precursor

Philip E. Auron; Charles A. Dinarello; Andrew C. Webb; Alexander Rich; Sheldon M. Wolff


Archive | 1992

Inhibition of cytokine activity

Charles A. Dinarello; Reuven Porat; Burton D. Clark; Sheldon M. Wolff


Archive | 1995

Biologically active fragments of IL-1β

Philip E. Auron; Charles A. Dinarello; Andrew C. Webb; Alexander Rich; Sheldon M. Wolff


Archive | 2011

Compositions, methods and uses for treatment of type 1 diabetes

Eli C. Lewis; Peter A. Gottlieb; Charles A. Dinarello; Leland Shapiro; Aaron Michels


Archive | 2011

Methods and compositions for islet cell preservation

Eli C. Lewis; Charles A. Dinarello; Leland Shapiro


Archive | 2011

COMPOSITIONS, METHODS AND USES FOR TREATING DIABETES

Lee Shapiro; Charles A. Dinarello; Eli C. Lewis; Peter A. Gottlieb; Amy Wallace; Aaron Michels; Gregory B. Potts

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Sheldon M. Wolff

Massachusetts Institute of Technology

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Eli C. Lewis

Ben-Gurion University of the Negev

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Lanny J. Rosenwasser

University of Missouri–Kansas City

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Leland Shapiro

University of Colorado Denver

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Aaron Michels

University of Colorado Boulder

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