Charles A. Jones

Macrophage migration inhibition in experimental diabetes.

Abstract To study the cause of increased susceptibility to infections in diabetes, peritoneal macrophages from normal, untreated and insulin-treated diabetic rats were isolated using thioglycollate as an irritant. Alterations in the number of macrophages, their in vitro ability to phagocytose, and migrate from a capillary chamber in response to murine migration inhibition factor (MIF) were investigated. The macrophages from the diabetic rats exhibited decreased sensitivity to MIF and also phagocytic activity with respect to sheep red blood cells. Insulin treatment for 10 to 15 days significantly improved these characteristics toward normal.

Life History of Manson's Blood Fluke (Schistosoma mansoni). III. The Blood Picture in Schistosomiasis Mansoni.∗

The blood picture in experimental mammals infected with S. mansoni shows first a leukocytosis, paralleling the migration of the larvae through the lungs. This is followed by a gradually developing leukopenia, with or without an eosinophilia, which, if present, is most pronounced about the end of the prepatent period. From about the 40th day there is an excess of euglobulin in the blood plasma. Moderate to late clinical cases usually give a positive precipitation test for serum globulin. The total erythrocyte counts are little altered in experimental and clinical cases, but there is definite evidence of regeneration of these cells, as indicated by a hyperplastic bone marrow and an increased reticulocyte count.