Charles B. Clayman

Induced primaquine resistance in vivax malaria

Abstract 1. 1) After 36 sequential subinoculations with suboptimal treatment of a single strain of vivax malaria, it has been possible to show a significant increase in trophozoite resistance to primaquine. In fact this resistance reached the point where maximum tolerated doses of primaquine had no action on parasitaemia and fever. This constitutes the maximum resistance that can be achieved in human volunteers. 2. 2) During this programme gametocytes were observed to form and were transmitted through mosquitoes to the stage of mature and apparently viable sporozoites. These failed to infect man. 3. 3) This induced resistance to primaquine should be one additional reason for always using primaquine in conjunction with a good blood schizontocide.

Adrenocortical and Pituitary Responsiveness Following Long-term, High Dosage Corticotropin Administration

Excerpt The purpose of this study was to investigate the effect of prolonged administration of corticotropin in high dosage on the function of the adrenal cortex and the pituitary gland. More infor...

The Effect of Corticotropin and Adrenal Steroids on Adrenocortical and Pituitary Responsiveness.

Excerpt Clinical experience has shown that the effect of adrenocorticotrophic hormone (ACTH) and the adrenal hormones, while frequently dramatic, is nevertheless variable and often disappointing. R...

The Human Central Nervous System: A Synopsis and Atlas

The Human Central Nervous System is an excellently diagrammed atlas and brief synopsis of neuroanatomy, extending to and from the cortices, depicting and defining functions of the afferent and efferent tracts. The descriptive material is at times distant from the diagrams, necessitating some shifting back and forth but preserving the continuity of the graphic and descriptive material. The drawings are well numbered and labeled, but the labels are in Latin and are abbreviated. Three-dimensional diagramming permits the viewer to follow tracts at various levels of the spinal cord or brain. The use of color at least to differentiate some of the nervus tracts would have further enhanced the book. Likewise the anatomy might have been more easily ingested and related had some effort been made to make clinical or physiological correlations. However, whatever deficiencies exist, they are more than compensated for by the beauty and clarity of the drawings. Medical

The Irritable Gut: Functional Disorders of the Alimentary Canal

Following an introductory description of the neural, muscular, and hormonal role in intestinal motility, the author discusses the importance of healthy bowel habits and the role of dietary fiber in normal defecation. He then briefly tries to relate the response of the gut to emotions and the importance of sigmoidoscopy in the evaluation of the bowel. The chapters are short, and the explanations are brief—perhaps a bit too brief for the student or generalist interested in basic principles that will permit him to build his understanding of this important segment of gastroenterology from them. For the gastroenterologist the material is rather oversimplified. Discussion of practical clinical aspects of constipation, functional diarrhea, gas, and dyspepsia is replete with numerous pointers that will render diagnosis and management of their problems much easier. In his discussion of laxatives, the author, recognizing and acknowledging the inadequacy and inaccuracy of the classification, nevertheless uses it

Human Disease in Color

Dr Smith has assembled full-color photographs of gross and microscopic specimens representing 140 different diseases of several of the organ systems of the body. To these he has added succinct case reports providing symptoms and findings as well as some of the natural history of the conditions presented. These reports and a comment regarding the pathological material are arranged to immediately precede or follow the photographs. The book is organized so each system is introduced with a description of a normal organ (heart, lung, brain, kidney, thyroid, and adrenal gland) and then is followed with clinical examples of infarction, inflammation, degenerative disease, neoplasia, and miscellaneous entities. Descriptions of the gross material are excellent, but the briefer discussions of the histopathological appearance could be expanded. A larger page format would have permitted greater clarity of some of the gross specimens, but more important the photomicrographs would then have been able to

Coronary Artery Disease: Recognition and Management

An exemplary product of the Specialized Center of Research on Ischemic Heart Disease founded by Dr Tinsley R. Harrison has been created by his latter-day descendants Drs Rackley and Russell and their colleagues at the University of Alabama Medical Center, Division of Cardiology. An efficiently organized, complete discussion of almost every aspect of coronary artery disease is presented for the primary care physician as well as for the student and the cardiologist. In clear language the authors introduce the reader to the problem, its natural history, manifestations, as well as factors in etiology and prognosis, including consideration of singleor multiple-vessel disease and left ventricular function. Noninvasive methods of evaluation, including kinetocardiography, echocardiography, exercise testing, and radionucleide study, are completely explained, and the reader is well able to appreciate the limits and benefits of each of these procedures. Arteriography, cardiac catheterization to evaluate left ventricular function, and left ventricular biplane angiography

Topics in Gastroenterology 5

A thorough and comprehensive review of selected subjects is provided in what is generally a lucid and assimilable fashion. If any criticism at all can be leveled, it might be that a bit more space has been given to cancer of the colon and surgery of the bile ducts, at the expense of the section on drugs and the liver, and five briefer topics, including a delightful and informative discussion of the virology and pathogenesis of acute infectious diarrhea.