Charles Botstein

Microwave applicators for localized hyperthermia treatment of cancer of the prostate

Abstract Directional coaxial applicators designed for operation with microwave frequencies of 915 MHz or 2450 MHz are described. Hyperthermia can be induced in tumors located within, or in the vicinity of, natural body cavities by means of these applicators. This paper reports on a method developed in animal experiments for the use of these applicators as therapeutic tools and on results of initial clinical trials using this technique in cases of cancer of the prostate.

The management of malignant thymoma with radiation therapy

Abstract Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1–6 years after initial excision. Eight patients were alive and free of disease 2–16 years after radiotherapy.Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1 to 6 yrs after initial excision. Eight patients were alive and free of disease 2 to 16 years after radiotherapy.

Microwave-induced hyperthermia in cancer treatment: apparatus and preliminary results.

Abstract Apparatus for the controlled local heating of cutaneous and subcutaneous tumors is described. This apparatus, which uses microwave radiation in the frequency 915 MHz or 2450 MHz, can raise the temperature of such tumors to the hyperthermic range (42.5–43°C), i.e. the temperature range which appears to be optimum for the treatment of malignant tumors. Encouraging results have been obtained with this apparatus in treating malignancies in laboratory animals and in man. Complete eradication of transplanted mammary adenocarcinoma was achieved in C3H mice. In several clinical cases, hyperthermis appeared to be beneficial in the treatment of basal. cell carcinoma, malignant melanoma, and skin metastases of carcinoma of the breast.

Treatment of carcinoma of the oral tongue by radium needle implantation.

Forty-nine patients had a radium implant for carcinoma of the oral tongue. In thirty-four of the forty-nine (70 per cent), local three year control of the cancer was achieved. Three patients in whom the radiation failed were rescued by subsequent surgery. The five year absolute survival in this series was 63.8 per cent. In conclusion, we believe that improved survival rates without functional and cosmetic defect can be obtained by closer cooperation between surgeons and radiotherapists.

The Use of Intrauterine and Intravaginal Radium in the Treatment of Carcinoma of the Bladder in Women

Eight women with advanced stage or high grade carcinoma of the bladder were treated in part with intrauterine and/or intravaginal radium. Local control was achieved in 7 cases. This is an effective form of treatment which should be considered for all women with bladder carcinoma.

The treatment of carcinoma of the bladder with high energy electrons.

Abstract A total of 112 patients with carcinoma of the urinary bladder were treated with high energy electrons or 35 meV X-rays. The vast majority of patients had been rejected for surgery; their average age was 10 years older than in most surgical series. The 5 year survival of patients was low, only 996. Among the 112 patients, 23 were treated with photons and 89 with electrons. The only difference between the groups was the larger sagittal diameter of patients in the smaller group which did not permit treatment with electrons. While none of the X-ray irradiated patients survived 5 years, the 5 year survival of the patients receiving electrons as the chief treatment modality was 14%

Brief communicationThe management of malignant thymoma with radiation therapy

Abstract Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1–6 years after initial excision. Eight patients were alive and free of disease 2–16 years after radiotherapy.Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1 to 6 yrs after initial excision. Eight patients were alive and free of disease 2 to 16 years after radiotherapy.

Management of malignant thymoma with radiation therapy. [Pleural complications]

Abstract Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1–6 years after initial excision. Eight patients were alive and free of disease 2–16 years after radiotherapy.Eleven patients were treated at Montefiore Hospital from 1962 to 1975 for malignant thymic tumor. Radiation therapy was administered in the immediate post-operative period or for recurrence 1 to 6 yrs after initial excision. Eight patients were alive and free of disease 2 to 16 years after radiotherapy.