Esther Friedenthal

Microwave applicators for localized hyperthermia treatment of cancer of the prostate

Abstract Directional coaxial applicators designed for operation with microwave frequencies of 915 MHz or 2450 MHz are described. Hyperthermia can be induced in tumors located within, or in the vicinity of, natural body cavities by means of these applicators. This paper reports on a method developed in animal experiments for the use of these applicators as therapeutic tools and on results of initial clinical trials using this technique in cases of cancer of the prostate.

Microwave-induced hyperthermia in cancer treatment: apparatus and preliminary results.

Abstract Apparatus for the controlled local heating of cutaneous and subcutaneous tumors is described. This apparatus, which uses microwave radiation in the frequency 915 MHz or 2450 MHz, can raise the temperature of such tumors to the hyperthermic range (42.5–43°C), i.e. the temperature range which appears to be optimum for the treatment of malignant tumors. Encouraging results have been obtained with this apparatus in treating malignancies in laboratory animals and in man. Complete eradication of transplanted mammary adenocarcinoma was achieved in C3H mice. In several clinical cases, hyperthermis appeared to be beneficial in the treatment of basal. cell carcinoma, malignant melanoma, and skin metastases of carcinoma of the breast.

Role of vitamin A and β carotene in radiation protection: relation to antioxidant properties

ELI SEIFTER * t , JOZEF MENDECKI + , SEYMOUR HOLTZMAN §, JACOB D. KANOFSKY¶, ESTHER FRIEDENTHAL + , LAWRENCE DAVIS ~: and JEFFREY WEINZWEIG* Denartments of *Surgery, t Biochemistry, and ¶Psychiatry, Albert Einstein College of Medicine, New York, U.S.A. (c Department of Radiation Oncology, Montefiore Medical Center, New York, U.S.A. §Department of Physiology, New York College of Osteopathic Medicine, Old Westbury, New York, U.S.A.

A Self-Balancing Microwave Radiometer for Non-Invasively Measuring the Temperature of Subcutaneous Tissues During Localized Hyperthermia Treatments of Cancer

The use of a self-balanced microwave radiometer in localized rf and microwave hyperthermia treatments of cancer is described. Initial clinical observations are presented.

Microwave treatments for prostate disease

This paper describes three novel microwave techniques that show promise for being useful in treating diseases of the prostate. They are (1) Microwave Urethroplasty for providing immediate symptomatic relief of urinary obstructions caused by BPH. This technique uses microwave balloon catheters for producing biological stents in the urethra. Initial results obtained in an FDA approved Phase I clinical trial are highly encouraging. (2) Hyperthermia produced in the prostate by dual microwave balloon catheters. When combined with external beam radiation or implanted radioactive seeds this technique has the potential of improving local recurrence rates of prostate cancer over the rates that are obtained when only radiation treatments are given. (3) Microwave Poration Therapy, a therapy that when combined with either systemic or locally administered chemotherapy has been shown to be effective in shrinking implanted prostatic tumors in rats. The potential clinical advantages of microwave poration/chemotherapy over electrochemotherapy using DC pulses for treating cancers are discussed.

A Microwave Apparatus for Producing Uniform Hyperthermic Temperatures Over Large Surfaces

A microwave apparatus that can produce uniform hyperthermic temperatures over large surface fields is described. The apparatus consists of a 2450 MHz power generator, a PIN diode power controller, a low-leakage non-contacting microwave applicator with an integral non-contacting infrared thermometer, a thermostat that provides feedback control and can be set to the desired tissue temperature, and a computer controlled mechanical arm that scans the applicator and the infrared thermometer over the treatment field.

27 MHz Waveguide Applicators for Localized Hyperthermia Treatment of Cancer

The design of a 27 MHz ridged-waveguide applicator for use in localized hyperthermia treatment of cancer is described. The design includes considerations for mechanical constraints and for the size and location of tumors. Results of animal and clinical experiments are given.

Enhancing the Efficacy of Localized Thermotherapy by Monitoring Changes in Tumor Blood Flow

Changes in the blood flow of tumors being heated with microwaves can be conveniently monitored by monitoring the applied heating power needed to maintain the tumors at given temperatures. Data obtained by this method are presented, and applications to clinical localized thermotherapy are discussed.

Microwave Thermotherapy of Recurrent Chest-Wall Carcinoma

During the past four years, 42 patients with chest-wall recurrence of breast carcinoma were treated with microwave thermotherapy and ionizing radiation. Complete or subtotal tumor regression and healing of lesions was achieved in about 70% of the patients.