Charles C. Wood

Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models.

Analysis of variance (ANOVA) interactions involving electrode location are often used to assess the statistical significance of differences between event-related potential (ERP) scalp distributions for different experimental conditions, subject groups, or ERP components. However, there is a fundamental incompatibility between the additive model upon which ANOVAs are based and the multiplicative effect on ERP voltages produced by differences in source strength. Using potential distributions generated by dipole sources in spherical volume conductor models, we demonstrate that highly significant interactions involving electrode location can be obtained between scalp distributions with identical shapes generated by the same source. Therefore, such interactions cannot be used as unambiguous indications of shape differences between distributions and hence of differences in source configuration. This ambiguity can be circumvented by scaling the data to eliminate overall amplitude differences between experimental conditions before an ANOVA is performed. Such analyses retain sensitivity to genuine differences in distributional shape, but do not confuse amplitude and shape differences.

Event-related potentials, lexical decision and semantic priming☆

ERPs were recorded during a lexical decision task in order to investigate electrophysiological concomitants of semantic priming. The stimuli were 240 words and 240 nonwords presented one per trial at a fixed intertrial interval. Subjects were required to classify each stimulus as a word or nonword by pressing one of two response buttons. ERPs were recorded from 14 scalp locations, the right suborbital ridge, and the left earlobe, all referred to a balanced non-cephalic reference. RT and error data confirmed that semantic priming occurred under the conditions employed: primed words (those preceded by a semantically related word) were identified as words faster and more accurately than were unprimed words (those preceded by semantically unrelated words or nonwords). ERPs for all stimulus types were characterized by a large positivity peaking between 550 and 650 msec, preceded by a negative-going deflection peaking at approximately 400 msec. ERPs for primed and unprimed words were shown to differ significantly, diverging 200-250 msec following stimulus onset, reaching a maximum near the peak of the negative-going deflection at 400 msec. These differences were observed at locations over both hemispheres and were maximal in the centroparietal region. Although P300 latency differences between primed and unprimed words were also obtained, the priming effect on ERPs at shorter latencies could not be explained solely by P300 latency effects. Possible relationships between these ERP concomitants of semantic priming and P300, N200, and N400 were discussed.

Brain stem auditory, pattern-reversal visual, and short-latency somatosensory evoked potentials: Latencies in relation to age, sex, and brain and body size

To determine standards of normality for auditory, somatosensory and visual evoked potentials commonly used in the assessment of neurological disease, 8 AEP, 1 VEP and 12 SEP components were recorded to stimulation of left and right ears, eyes, and median nerves in 286 normal subjects ranging in age from 4 to 95 years. Peak and interpeak latencies, and left-right differences in latency, were analyzed as a function of age, sex, and estimates of brain and body size. Major features of the results were: (1) Peak latencies of all components showed statistically significant increases in latency with age except that VEP P100 latency decreased significantly between 4 and 19 years and did not change between 20 and 59 years. (2) In adults the peak latencies of all components were significantly later in males than in females. For AEPs and VEPs these differences were explained by sex differences in brain size, and for adult SEPs were explained by sex differences in arm and shoulder dimensions. No significant sex differences in VEP and SEP latencies were seen in children. (3) Most interpeak latencies showed significant differences in relation to age or sex. (4) Age and sex are useful predictors of latency for nearly all peak and interpeak latencies; in addition, height is a useful predictor of SEP peak latencies. (5) Left-right latency differences showed little age-related, and no sex-related, change. The interlaboratory use of these or other normative data was discussed. It was concluded that these AEP and SEP norms can probably be used in other laboratories if stimulating and recording conditions are similar. However, VEP results are difficult to transfer due to the poorly understood effects of variation in stimulus conditions. Some issues regarding the optimal characterization of norms were also discussed.

Scalp distribution of human auditory evoked potentials. II. Evidence for overlapping sources and involvement of auditory cortex

The scalp distributions of human auditory evoked potentials (AEPs) between 20 and 250 msec were investigated using non-cephalic reference recordings. AEPs to binaural click stimuli were recorded simultaneously from 20 scalp locations over the right hemisphere in 11 subjects. Computer-generated isovoltage topographic maps at high temporal resolution were used to assess the stability of AEP scalp distributions over time and relate them to major peaks in the AEP wave forms. For potentials between 20 and 60 msec, the results demonstrate a stable scalp distribution of dipolar form that is consistent with sources in primary auditory cortex on the superior temporal plant near the temporoparietal junction. For potentials between 60 and 250 msec, the results demonstrate changes in AEP morphology across electrode locations and changes in scalp distribution over time that lead to two major conclusions. First, AEPs in this latency period are generated by multiple sources which partially overlap in time. Second, one or more regions of auditory cortex contribute significantly to AEPs in this period. Additional data are needed to determine the relative contribution of auditory cortex sources on the superior temporal plane and the lateral temporal surface and to identify AEP sources outside the temporal lobe.

Principal component analysis of event-related potentials: Simulation studies demonstrate misallocation of variance across components ☆

Simulated event-related potential (ERP) components were used to investigate the ability of principal component analysis (PCA), Varimax rotation and univariate analysis of variance (ANOVA) to reconstruct component wave shapes, to allocate variance correctly across components, and to identify the correct locus of simulated experimental treatments. The simulated ERPs consisted of 800 randomly weighted combinations of three 64-point components, corresponding to a 2 X 2 X 10 repeated-measures design with 20 subjects. Covariance PCAs, Varimax rotations and univariate ANOVAs were performed on each of 400 such simulations, 100 with no effect of any experimental treatment and 100 each with main effects on each of the 3 components. Eight hundred additional simulations were performed to investigate the effects of systematic variations in the size of the experimental treatments and the number of subjects per experiment. The wave shapes of the simulated components were reconstructed reasonably well, although not completely, by the rotated principal component (PC) loadings. However, comparison of rotated PC scores with the random weights used to generate the simulated ERPs indicated that PCA incorrectly allocated variance across overlapping components, producing dramatic increases in type I error (the largest in excess of 80%) for ANOVAs on one component when the true treatment effect was on another. Although these results should not be overgeneralized, they clearly demonstrate that the PCA-Varimax-ANOVA strategy can incorrectly distribute variance across components, resulting in serious misinterpretation of treatment effects. Additional simulation studies are needed to determine the generality of the variance misallocation problem; pending the outcome of such studies, results obtained with the PCA-Varimax-ANOVA strategy should be interpreted cautiously.

Anatomical and Physiological Substrates of Event‐Related Potentials: Two Case Studies

Because an excellent tutorial introduction to the anatomical and physiological substrates of event-related potentials (ERPs) is available (Goff et al.. 1978), our objective in this chapter is not a general tutorial review. Rather, we intend to consider in detail the anatomical and physiological substrates of two classes or families of ERPs that have been the subject of intense investigation in recent years: (a) the auditory “ N I P ~ complex” and (b) P300 and related “endogenous” potentials. Our hope is that such a “case study” approach to ERP substrates will not only provide the reader with a thorough review of recent research findings, but will also provide a critical analysis of both the theoretical and empirical foundations of inferences about the neural substrates of ERPs. Our consideration of each family of potentials will consist of (a) a brief descriptive introduction, including the identifying characteristics of the potentials under consideration and the experimental conditions under which they can be obtained; (b) a detailed consideration of the different types of evidence that have been used to formulate and

ERPs predictive of subsequent recall and recognition performance

By exploiting measures of information processing complementary to those obtained from behavioral studies, electrophysiological studies of human memory may provide insights into the cognitive processes associated with encoding. In the present experiment, subjects viewed words under incidental learning conditions in which each word required a two-choice decision based on semantic criteria (interesting/uninteresting or edible/inedible). Memory for those words was subsequently assessed by a free recall test and then a recognition test. Event-related brain potentials elicited in response to the original presentation of each word were found to differ as a function of later memory performance. Over the 400-800 ms latency range, responses to remembered words were positive relative to responses to forgotten words, especially for recall. These electrophysiological differences are interpreted as reflections of processes that correlated with encoding.

Potentials evoked in human and monkey medial temporal lobe during auditory and visual oddball paradigms

Event-related potentials (ERPs) were recorded from epileptic patients with electrodes chronically implanted in the medial temporal lobe (MTL) and other intracranial locations, and from monkeys with epidural, transcortical, and MTL electrodes. For both humans and monkeys, the eliciting events consisted of trains of auditory or visual stimuli in which a random 10-20% deviated in pitch or pattern from the remaining stimuli. The distribution of ERPs elicited by the rare (oddball) stimuli in both species was similar, consisting of a P3 recorded from the scalp or cortical surface and a slightly later, but temporally overlapping, focal negativity in the hippocampus and nearby MTL structures. The similarity between the patterns of ERPs in humans and monkeys establishes the feasibility of studying the electrogenesis of P3-like activity with detailed intracranial recordings in an animal model. The data also establish that the MTL ERPs in human patients represent a normal neurophysiological process unrelated to epilepsy.

Parallel processing of auditory and phonetic information in speech discrimination.

Recent experiments using a variety of techniques have suggested that speech perception involves separate auditory and phonetic levels of processing. Two models of auditory and phonetic processing appear to be consistent with existing data: (a) a strictserial model in which auditory information would be processed at one level, followed by the processing of phonetic information at a subsequent level; and (b) aparallel model in which auditory and phonetic processing could proceed simultaneously. The present experiment attempted to distinguish empirically between these two models. Ss identified either an auditory dimension (fundamental frequency) or a phonetic dimension (place of articulation of the consonant) of synthetic consonant-vowel syllables. When the two dimensions varied in a completely correlated manner, reaction times were significantly shorter than when either dimension varied alone. This “redundancy gain” could not be attributed to speed-accuracy trades, selective serial processing, or differential transfer between conditions. These results allow rejection of a completely serial model, suggesting instead that at least some portion of auditory and phonetic processing can occur in parallel.

Discriminability, response bias, and phoneme categories in discrimination of voice onset time.

The ’’phoneme‐boundary effect’’ refers to the observation that discrimination of stop consonants across a boundary between phoneme categories is superior to discrimination of comparable stimulus differences within a phoneme category. The present experiment employed signal detection methodology (a) to distinguish between changes in discriminability and response bias; and (b) to reevaluate the role of phonetic categorization in the phoneme‐boundary effect. A SAME–DIFFERENT discrimination task compared discrimination of 10− and 20−msec differences in voice onset time (VOT) in a synthetic stimulus continuum ranging from [ba] to [pa] (VOT’s from −50 to +70 msec). Both a clear increase in discriminability and a marked shift in response bias from SAME to DIFFERENT occurred near the voiced–voiceless boundary. When variations in VOT were isolated from syllable context so that they were not categorized as phonemes, discriminability increased near the voiced–voiceless boundary in a manner comparable to the full‐syll...