Charles R. Reagan
Emory University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Charles R. Reagan.
Journal of Clinical Investigation | 1973
John B. Mills; Charles R. Reagan; Daniel Rudman; Jack L. Kostyo; P. Zachariah; Alfred E. Wilhelmi
As a first step in our study of structure-function relationships among primate and non-primate growth hormones, human growth hormone (hGH) was subjected to the limited digestive activity of human plasmin. The lyophilized whole digest, containing less than 2% of unchanged hormone, had an average of 2.3 new amino-terminal groups per mole. The digest had the same potency as the native hormone (a) in causing weight gain in hypophysectomized rats; (b) in stimulating somatomedin production in hypophysectomized rats; (c) in stimulating upake of [(3)H]leucine into isolated diaphragm of hypophysectomized rats; (d) in accelerating transport of [(14)C]alpha-aminoisobutyric acid into isolated diaphragm of hypophysectomized rats; (e) in stimulating uptake of [3-0-methyl-(14)C]glucose by isolated adipose tissue of hypophysectomized rats; (f) in accelerating conversion of [(14)C]glucose to (14)CO(2) by isolated epididymal adipose tissue of hypophysectomized rats. The digest also caused glucosuria in partially pancreatectomized rats treated with dexamethasone. These metabolic actions of plasmin-digested hGH in the array of animal tests were confirmed by comparable effects elicited in 11 human subjects (nine pituitary-deficient children and adolescents and two nondeficient adults). A single injection of the plasmin digest caused an increase in plasma free fatty acids and a fall in plasma amino acids. Seven daily injections caused positive balances of nitrogen, phosphorous, sodium, and potassium, gain in body weight, and in two of three subjects impairment of glucose tolerance. The potency of the plasmin digest in producing these metabolic effects in man was comparable to that of native hGH.Thus, 2-3 bonds in the hGH molecule can be cleaved by plasmin without impairing the hormones growthpromoting, anabolic, diabetogenic, and adipokinetic actions for rat and man.
Endocrinology | 1980
Katherine D. Fagin; Suzette Lackey; Charles R. Reagan; Mario DiGirolamo
The Journal of Clinical Endocrinology and Metabolism | 1974
Knut Uthne; Charles R. Reagan; Lynn P. Gimpel; Jack L. Kostyo
Endocrinology | 1980
John B. Mills; Jack L. Kostyo; Charles R. Reagan; S. A. Wagner; Martha H. Moseley; Alfred E. Wilhelmi
Endocrinology | 1978
Olle Isaksson; David F. Nutting; Jack L. Kostyo; Charles R. Reagan
Endocrinology | 1975
Charles R. Reagan; John B. Mills; Jack L. Kostyo; Alfred E. Wilhelmi
Endocrinology | 1978
Charles R. Reagan; Jack L. Kostyo; John B. Mills; Martha H. Moseley; Alfred E. Wilhelmi
Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology | 1976
Jack L. Kostyo; Charles R. Reagan
Endocrinology | 1981
Charles R. Reagan; Jack L. Kostyo; John B. Mills; S. E. Gennick; J. L. Messina; S. A. Wagner; Alfred E. Wilhelmi
Endocrinology | 1979
Olle Isaksson; Jessica Schwartz; Jack L. Kostyo; Charles R. Reagan