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Dive into the research topics where Chengtao Wang is active.

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Featured researches published by Chengtao Wang.


Rapid Prototyping Journal | 2010

Fabrication and compressive properties of Ti6Al4V implant with honeycomb‐like structure for biomedical applications

Xiang Li; Chengtao Wang; Wenguang Zhang; Yuanchao Li

Purpose – The purpose of this paper is to verify the feasibility and evaluate the compressive properties of Ti6Al4V implants with controlled porosity via electron beam melting process. This process might be a promising method to fabricate orthopedic implants with suitable pore architecture and matched mechanical properties.Design/methodology/approach – Ti6Al4V implants with controlled porosity are produced using an electron beam melting machine. A scanning electron microscope is utilized to examine the macro‐pore structures of the Ti6Al4V implants. The compressive test is performed to investigate the mechanical properties of the porous implants.Findings – The fabricated samples show a fully interconnected open‐pore network. The compressive yield strength of the Ti6Al4V implants with the porosity of around 51 percent is higher than that of human cortical bone. The Youngs modulus of the implants is similar to that of cortical bone.Research limitations/implications – The surface of samples produced by elect...


PLOS ONE | 2012

Evaluation of Biological Properties of Electron Beam Melted Ti6Al4V Implant with Biomimetic Coating In Vitro and In Vivo

Xiang Li; Ya-Fei Feng; Chengtao Wang; Guochen Li; Wei Lei; Zhiyong Zhang; Lin Wang

Background High strength porous titanium implants are widely used for the reconstruction of craniofacial defects because of their similar mechanical properties to those of bone. The recent introduction of electron beam melting (EBM) technique allows a direct digitally enabled fabrication of patient specific porous titanium implants, whereas both their in vitro and in vivo biological performance need further investigation. Methods In the present study, we fabricated porous Ti6Al4V implants with controlled porous structure by EBM process, analyzed their mechanical properties, and conducted the surface modification with biomimetic approach. The bioactivities of EBM porous titanium in vitro and in vivo were evaluated between implants with and without biomimetic apatite coating. Results The physical property of the porous implants, containing the compressive strength being 163 - 286 MPa and the Young’s modulus being 14.5–38.5 GPa, is similar to cortical bone. The in vitro culture of osteoblasts on the porous Ti6Al4V implants has shown a favorable circumstance for cell attachment and proliferation as well as cell morphology and spreading, which were comparable with the implants coating with bone-like apatite. In vivo, histological analysis has obtained a rapid ingrowth of bone tissue from calvarial margins toward the center of bone defect in 12 weeks. We observed similar increasing rate of bone ingrowth and percentage of bone formation within coated and uncoated implants, all of which achieved a successful bridging of the defect in 12 weeks after the implantation. Conclusions This study demonstrated that the EBM porous Ti6Al4V implant not only reduced the stress-shielding but also exerted appropriate osteoconductive properties, as well as the apatite coated group. The results opened up the possibility of using purely porous titanium alloy scaffolds to reconstruct specific bone defects in the maxillofacial and orthopedic fields.


Materials Science and Engineering: C | 2013

Tantalum coating on porous Ti6Al4V scaffold using chemical vapor deposition and preliminary biological evaluation

Xiang Li; Lin Wang; Xiaoming Yu; Ya-Fei Feng; Chengtao Wang; Ke Yang; Daniel Su

Porous tantalum (Ta), produced via chemical vapor deposition (CVD) of commercially pure Ta onto a vitreous carbon, is currently available for use in orthopedic applications. However, the relatively high manufacturing cost and the incapability to produce customized implant using medical image data have limited its application to gain widespread acceptance. In this study, Ta film was deposited on porous Ti6Al4V scaffolds using CVD technique. Digital microscopy and scanning electron microscopy indicated that the Ta coating evenly covered the entire scaffold structure. X-ray diffraction analysis showed that the coating consisted of α and β phases of Ta. Goat mesenchymal stem cells were seeded and cultured on the Ti6Al4V scaffolds with and without coating. The tetrazolium-based colorimetric assay exhibited better cell adhesion and proliferation on Ta-coated scaffolds compared with uncoated scaffolds. The porous scaffolds were subsequently implanted in goats for 12weeks. Histological analysis revealed similar bone formation around the periphery of the coated and uncoated implants, but bone ingrowth is better within the Ta-coated scaffolds. To demonstrate the ability of producing custom implant for clinical applications via this technology, we designed and fabricated a porous Ti6Al4V scaffold with segmental mandibular shape derived from patient computerized tomography data.


Rare Metal Materials and Engineering | 2010

Fabrication of Bioactive Titanium with Controlled Porous Structure and Cell Culture in Vitro

Xiang Li; Chengtao Wang; Lin Wang; Wenguang Zhang; Yuanchao Li

Abstract One of the direct metal forming techniques, electron beam melting (EBM) process, was used to fabricate Ti6Al4V implants with controllable porous structure. The micro-structural pore characterization, porosity and mechanical properties of the fabricated implants were investigated. Scanning electron microscope (SEM) observation shows that the porous structure of fabricated samples coincide with the designed architecture. It is demonstrated that EBM process can provide accurate control over the internal pore architectures of the implant. The compressive strength of the implant with porosity of 60.1% is 163 MPa. The Youngs modulus is 14 GPa, which is similar to that of cortical bone. The surface modification by improved alkali-heat treatment induces apatite formation in simulated body fluid (SBF). In vitro cell culture experiment results reveal that osteoblasts will spread and proliferate on the surface of modified specimens over a culture time of 7 d.


Materials Letters | 2009

Fabrication and characterization of porous Ti6Al4V parts for biomedical applications using electron beam melting process

Xiang Li; Chengtao Wang; Wenguang Zhang; Yuanchao Li


The International Journal of Advanced Manufacturing Technology | 2005

Sectional multipoint forming technology for large-size sheet metal

Jipeng Chen; Min Li; Wei Liu; Chengtao Wang


Archive | 2012

Bone restoration body with composite porous structure and preparation method thereof

Xiang Li; Yun Luo; Chengtao Wang


Composites Science and Technology | 2015

A novel composite scaffold consisted of porous titanium and chitosan sponge for load-bearing applications: Fabrication, characterization and cellular activity

Xiang Li; Xiang-Yu Ma; Ya-Fei Feng; Lin Wang; Chengtao Wang


The International Journal of Advanced Manufacturing Technology | 2004

Fabricating auricular prostheses based on rapid prototyping and the FreeForm modelling system

X. Huang; Ming Ye; Wenchuan Zhang; Chengtao Wang; T. Jiao


Materials Letters | 2012

Preparation and characterization of porous Ti6Al4V/alginate hybrid implant by combination of electron beam melting and freeze-drying

Xiang Li; Yun Luo; Chengtao Wang

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Xiang Li

Shanghai Jiao Tong University

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Lin Wang

Fourth Military Medical University

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Wenguang Zhang

Shanghai Jiao Tong University

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Yuanchao Li

Shanghai Jiao Tong University

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Ya-Fei Feng

Fourth Military Medical University

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Yun Luo

Shanghai Jiao Tong University

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Guochen Li

Fourth Military Medical University

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Wei Lei

Fourth Military Medical University

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Daniel Su

Shanghai Jiao Tong University

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Guoxian Pei

Fourth Military Medical University

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