Chieko Tahara
Teikyo University
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Featured researches published by Chieko Tahara.
Thrombosis Research | 1990
Yoshiko Akiyama; Mutsuyoshi Kazama; Chieko Tahara; Chisato Shimazu; Junko Otake; Kieko Kamei; Toshihiko Nakatake; Noriko Sakurai; Yoko Yasumuro; Setsuko Suzuki; Eiko Maeba; Toshiro Nishida
The circadian fluctuation of hemostasis related parameters was examined on 16 healthy Japanese adults (male 9, female 7). Twenty one parameters were measured in this study, i.e. fibrinogen, the activity of F.II, F.V., F.VII, F.VIII, F.IX, F.X., F.XI, F.XII, antithrombin III, plasminogen, alpha 2-antiplasmin, as well as the antigen level of F.IX, von Willebrand Factor, protein C, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), beta-thromboglobulin, platelet factor 4, fibrinopeptide A, plasmin-alpha 2-antiplasmin complex and FDP. Fluctuation was not significant in almost all of the parameters except F.VIII, F.IX, beta-thromboglobulin, platelet factor 4, tPA and PAI-1. Although the fluctuations of F.VIII, F.IX, beta-thromboglobulin and platelet factor 4 were statistically significant, they remained within the normal ranges. On the other hand, tPA and free PAI-1 showed significant circadian fluctuation, of which levels were highest at 9:00. It was postulated that the significant circadian fluctuation of fibrinolytic activity will be regulated by the balance between tPA and PAI-1 in plasma.
Thrombosis Research | 1992
Kazuyoshi Sawada; Hitoshi Yamamoto; Kenji Matsumoto; Hisashi Yago; Seishi Suehiro; Chieko Tahara; Hidemi Ishii; Mutsuyoshi Kazama; Takeshi Abe
Changes in the plasma thrombomodulin (TM) level were examined in endotoxin-infused rabbits. The plasma TM level in normal rabbits was 143.8 +/- 8.4 ng/ml (n = 67) and the molecular weight of the major TM was about 55 kd. Endotoxin (lipopolysaccharide, LPS, E. Coli B8:0127) was intravenously infused. LPS infusion increased the plasma TM level dose-dependently between 0.2 mg/kg and 5 mg/kg. When 5 mg/kg LPS was infused, the plasma TM level started to increase immediately and was 2.3 times higher than the control value within 1 hr. The molecular weight of the major TM was about 75 kd. This rapid increase in TM occurred before the decrease in fibrinogen content and the prolongation of prothrombin time. To examine the effect of circulating leukocytes on the TM increase in endotoxin-infused rabbits, 5 mg/kg LPS was infused into rabbits with leukocytopenia induced by X-ray irradiation. The maximum plasma level of TM was significantly lower than in the untreated rabbits given LPS. These data suggest that the increase in plasma TM is caused by LPS-stimulated leukocytes prior to hemostaseological changes. It is well known that endothelial cells can be injured by stimulated leukocytes, so this increase in plasma TM probably reflects the deterioration of endothelial cells. This deterioration decreases the ability of endothelial cells to inhibit thrombosis, which would, in turn, contribute to the development of disseminated intravascular coagulation in endotoxin-infused rabbits.
Journal of the Japan Society of Blood Transfusion | 1989
Jun Teruya; Akemi Umejima; Yumi Saitoh; Emiko Maruyama; Yurie Shimizu; Mutsuyoshi Kazama; Machiko Morioka; Chieko Tahara
Because plasma is in much demand but very short in selfsufficiency in Japan, it is not enough to get source plasma derived only from 200ml or 400ml donations of whole blood. As a less expensive process whereby plasma is collected from a single voluntary donor, membrane plasmapheresis has been initiated.We investigated the safety of donating plasma and the efficacy of collected plasma by using a membrane plasmapheresis apparatus, KM8700 Kuraray. There were no complaints from 20 voluntary donors and no abnormal vital signs observed. And there was no activation of platelet, coagulation, fibrinolysis, and complement systems.The components in collected plasma showed little difference from fresh frozen plasma supplied by the Japanese Red Cross, except for a slightly low level of factor IX.We concluded that donor membrane plasmapheresis by using KM8700 Kuraray was safe and clinically useful.
Thrombosis and Haemostasis | 1990
Hidemi Ishii; Masahiko Nakano; Jiro Tsubouchi; Tai-ichi Ishikawa; Hiroyuki Uchiyama; Sayuri Hiraishi; Chieko Tahara; Yukari Miyajima; Mutsuyoshi Kazama
Thrombosis Research | 1981
Mutsuyoshi Kazama; Chieko Tahara; Z. Suzuki; Kengo Gohchi; Takeshi Abe
Thrombosis and Haemostasis | 1990
Mutsuyoshi Kazama; Setsuko Suzuki; Takeshi Abe; Chieko Tahara; Chisato Shimazu; Yoshiko Akiyama; Katsumi Higashi; Izumi Ishiguro; Toshiyuki Kimura; Shigemi Motoi; Kazuo Tsukai; Masaki Kobayashi; Yoshimasa Niwa; Hisao Makita; Yoko Yasumuro; Toshihiko Nakatake
Thrombosis Research | 1988
Mutsuyoshi Kazama; Chieko Tahara; Takeshi Abe; K. Kasai
Japanese Journal of Thrombosis and Hemostasis | 1989
Chieko Tahara; Mutsuyoshi Kazama; Yukari Miyajima; Takeshi Abe
Japanese Journal of Thrombosis and Hemostasis | 1988
Mutsuyoshi Kazama; Chieko Tahara; Kenji Matsumoto; Qilang Zhang; Iwao Naito; Juzo Matsuda; Takeshi Abe
Japanese journal of medical science & biology | 1977
Takeshi Abe; Mutsuyoshi Kazama; Chieko Tahara; Yasuhiro Miura; Junichi Yasuda