Chixu Chen

Synthesis of dihydropyridone scaffolds on solid support: Resin activation/capture approach/REACAP technology

Abstract Resin Activation/Capture Approach (REACAP Technology) has been used to synthesize dihydropyridone scaffolds on solid support.

Solid phase synthesis of 2,4-disubstituted pyridine and tetrahydropyridine derivatives: Resin activation/capture approach/REACAP technology

Abstract The resin-bound dihydropyridone scaffold generated using the Resin Activation/Capture Approach (REACAP) Technology was further elaborated to afford 2,4-disubstituted pyridine and tetrahydropyridine derivatives. This process car be envisaged as the functionalization of pyridine analogues on solid support by a traceless linker approach.

Solid phase synthesis of N-acyl-2-substituted-dihydro-4-pyridone: Resin Activation/Capture Approach/REACAP Technology

Abstract Resin Activation/Capture (REACAP) Technology was used to prepare N -acyl-2-substituted-dihydro-4-pyridone analogs.

Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin Activation/Capture Approach/REACAP Technology

Abstract The resin-bound enol ether scaffold generated using the Resin Activation/Capture Approach (REACAP) Technology was further elaborated via a stereospecific Diels-Alder addition to afford a series of highly rigid substituted 5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs.