Christian Stanek

Methicillin-resistant Staphylococcus aureus ST398 in Humans and Animals, Central Europe

Isolates found in persons and animals in Germany and Austria show a genetic relationship.

Clusters of Infections in Horses with MRSA ST1, ST254, and ST398 in a Veterinary Hospital

During 2006 and 2007 small clusters of methicillin-resistant Staphylococcus aureus (MRSA) infections in horses were recorded in different clinical departments of a veterinary university. The infections were caused by different MRSA clones (ST1, ST254, and ST398). In the same time, nasal colonization of veterinarians, veterinary personnel, and students was observed indicating transmission to humans.

Radiation of jejunal interposition in T3–T4 upper aerodigestive tumours

30 patients with T3 and T4 tumours of the upper aerodigestive tract had their tumours resected by pharyngolaryngectomy. This was followed by reconstruction of a gullet or creation of a siphon as a tracheohypopharyngeal shunt for voice restoration with a free jejunal autograft. All patients were treated postoperatively with 60Co gamma radiation, 6 MeV photons or 7.5 to 10 MeV electrons of a beta-tron, with a dose of 50-65 Gy in the area of the primary tumour and 50-65 Gy to the neck. 4 patients refused further treatment after a depth dose of between 16 and 32 Gy. Local recurrence occurred in 40% of cases. The survival rate was 36.6% (11/30) after a mean follow-up time of 21.5 months, although 2 patients died of intercurrent diseases without recurrence of their tumours. The results obtained justify active surgical intervention with postoperative irradiation even at an advanced stage of the tumour.

Speicheldrüsen I: Tumoren

Die Pathogenese der verschiedenen Speicheldrusengeschwulste ist bislang noch nicht geklart. Ebenso existieren uber die Atiologie dieser Tumoren nur sparliche Informationen. Verschiedene Faktoren wurden bislang als epidemiologisch relevant bei der Entstehung von Parotistumoren diskutiert: Als viral-infektiose Faktoren wurden das Epstein-Barr-Virus, Zytomegalie-Virus, verschiedene oncogene DNA-Viren, Adenoviren, Simian-40-Viren und das Polyoma-Virus in Zusammenhang mit der Entstehung von Parotistumoren gebracht. Chromosomale Faktoren, wie clonale Aberrationen von Chromosom Nr. 8, chromosomale Translokationen und Verlust von Chromosomen wurden beobachtet. Neben mehreren anderen Faktoren wurden schlieslich ionisierende Strahlen anhand vieler Studien, die sich u.a. mit den Folgen der Hiroshima-Atombombenexplosion sowie therapeutischer und diagnostischer Strahlenbelastung beschaftigten, fur die Entwicklung von Parotistumoren verantwortlich gemacht.