Christiana I. Iwuagwu
Bristol-Myers Squibb
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Publication
Featured researches published by Christiana I. Iwuagwu.
ACS Medicinal Chemistry Letters | 2017
Dalton King; Christiana I. Iwuagwu; Jim Cook; Ivar M. McDonald; Robert A. Mate; F. Christopher Zusi; Matthew D. Hill; Haiquan Fang; Rulin Zhao; Bei Wang; Amy Easton; Regina Miller; Debra J. Post-Munson; Ronald J. Knox; Lizbeth Gallagher; Ryan Westphal; Thaddeus F. Molski; Jingsong Fan; Wendy Clarke; Yulia Benitex; Kimberley A. Lentz; Rex Denton; Daniel J. Morgan; Robert Zaczek; Nicholas J. Lodge; Linda J. Bristow; John E. Macor; Richard E. Olson
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provide an effective approach to treating cognitive dysfunction in schizophrenia. We report herein the discovery and evaluation of 1c (BMS-933043), a novel and potent α7 nACh receptor partial agonist with high selectivity against other nicotinic acetylcholine receptor subtypes (>100-fold) and the 5-HT3A receptor (>300-fold). In vivo activity was demonstrated in a preclinical model of cognitive impairment, mouse novel object recognition. BMS-933043 has completed Phase I clinical trials.
Archive | 2009
H. Cook Ii James; Ivar M. McDonald; Dalton King; Richard E. Olson; Nenghui Wang; Christiana I. Iwuagwu; F. Christopher Zusi; John E. Macor
PLOS ONE | 2016
Linda J. Bristow; Amy Easton; Yu-Wen Li; Digavalli V. Sivarao; Regina Lidge; Kelli M. Jones; Debra J. Post-Munson; Christopher Daly; Nicholas J. Lodge; Lizbeth Gallagher; Thaddeus F. Molski; Richard Pieschl; Ping Chen; Adam Hendricson; Ryan Westphal; James M. Cook; Christiana I. Iwuagwu; Daniel J. Morgan; Yulia Benitex; Dalton King; John E. Macor; Robert Zaczek; Richard K. Olson
Journal of Medicinal Chemistry | 2016
James M. Cook; F. Christopher Zusi; Ivar M. McDonald; Dalton King; Matthew D. Hill; Christiana I. Iwuagwu; Robert A. Mate; Haiquan Fang; Rulin Zhao; Bei Wang; Jingfang Qian Cutrone; Baoqing Ma; Qi Gao; Ronald J. Knox; Michele Matchett; Lizbeth Gallagher; Meredith Ferrante; Debra J. Post-Munson; Thaddeus F. Molski; Amy Easton; Regina Miller; Kelli M. Jones; Siva Digavalli; Francine Healy; Kimberley A. Lentz; Yulia Benitex; Wendy Clarke; Joanne Natale; Judith A. Siuciak; Nicholas J. Lodge
Archive | 2011
Kimberley A. Lentz; Rex Denton; James Cook; Ivar M. McDonald; Dalton King; Richard E. Olson; Nenghui Wang; Robert A. Mate; Christiana I. Iwuagwu; F. Christopher Zusi; John E. Macor; Matthew D. Hill; Haiquan Fang
ACS Medicinal Chemistry Letters | 2017
Matthew D. Hill; Haiquan Fang; H. Dalton King; Christiana I. Iwuagwu; Ivar M. McDonald; James Cook; F. Christopher Zusi; Robert A. Mate; Ronald J. Knox; Debra J. Post-Munson; Amy Easton; Regina Miller; Kimberley A. Lentz; Wendy Clarke; Yulia Benitex; Nicholas J. Lodge; Robert Zaczek; Rex Denton; Daniel J. Morgan; Linda J. Bristow; John E. Macor; Richard E. Olson
Bioorganic & Medicinal Chemistry Letters | 2017
Christiana I. Iwuagwu; Dalton King; Ivar M. McDonald; James Cook; F. Christopher Zusi; Matthew D. Hill; Robert A. Mate; Haiquan Fang; Ronald J. Knox; Lizbeth Gallagher; Debra Post-Munson Amy Easton; Regina Miller; Yulia Benitex; Judy Siuciak; Nicholas J. Lodge; Robert Zaczek; Daniel G. Morgan; Linda J. Bristow; John E. Macor; Richard E. Olson
Archive | 2010
Ivar M. McDonald; Robert A. Mate; H. Cook Ii James; Dalton King; Richard E. Olson; Nenghui Wang; Christiana I. Iwuagwu; F. Christopher Zusi; Matthew D. Hill; Haiquan Fang; John E. Macor
Archive | 2009
H. Cook Ii James; Ivar M. McDonald; Dalton King; Richard E. Olson; Nenghui Wang; Christiana I. Iwuagwu; F. Christopher Zusi; John E. Macor
Archive | 2010
Ivar M. McDonald; Robert A. Mate; Ii James H. Cook; Dalton King; Richard E. Olson; Nenghui Wang; Christiana I. Iwuagwu; F. Christopher Zusi; Matthew D. Hill; Haiquan Fang; John E. Macor
