Chuanming Yu

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry

Mechanochemical conditions have been applied to a highly efficient cobalt(III)-catalyzed C-H bond activation for the first time. In a subsequent step to the olefin insertion and β-oxygen elimination, N-pyrimidinylindoles were allylated with vinylethylene carbonates in the absence of organic solvent under high-speed ball-milling condition. As the reaction afforded the desired products in up to 98% yields within a short time, this method constitutes an environmentally friendly and powerful alternative to the common solution-based approaches.

Ru(II)-Catalyzed C6-selective C–H amidation of 2-pyridones

Ru(II)-Catalyzed C6 site-selective amidation of 2-pyridones with 1,4,2-dioxazol-5-ones has been developed. The reaction occurred with a low catalyst loading and broad substrate scope under mild conditions, affording desired products in up to 98% yields within a short time.