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Dive into the research topics where Chung-Pin Chen is active.

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Featured researches published by Chung-Pin Chen.


Journal of Medicinal Chemistry | 2012

Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment 6. Preclinical and Human Pharmacokinetic Profiling of BMS-663749, a Phosphonooxymethyl Prodrug of the HIV-1 Attachment Inhibitor 2-(4-Benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043)

John F. Kadow; Yasutsugu Ueda; Nicholas A. Meanwell; Timothy P. Connolly; Tao Wang; Chung-Pin Chen; Kap-Sun Yeung; Juliang Zhu; John A. Bender; Zhong Yang; Dawn D. Parker; Pin-Fang Lin; Richard J. Colonno; Marina Mathew; Daniel Morgan; Ming Zheng; Caly Chien; Dennis M. Grasela

BMS-663749, a phosphonooxymethyl prodrug 4 of the HIV-1 attachment inhibitor 2-(4-benzoyl-1-piperazinyl)-1-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoethanone (BMS-488043) (2) was prepared and profiled in a variety of preclinical in vitro and in vivo models designed to assess its ability to deliver parent drug following oral administration. The data showed that prodrug 4 had excellent potential to significantly reduce dissolution rate-limited absorption following oral dosing in humans. Clinical studies in normal healthy subjects confirmed the potential of 4, revealing that the prodrug significantly increased both the AUC and C(max) of 2 compared to a solid capsule formulation containing the parent drug upon dose escalation. These data provided guidance for further efforts to obtain an effective HIV-1 attachment inhibitor.


Bioorganic & Medicinal Chemistry Letters | 2003

Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties

Yasutsugu Ueda; John D. Matiskella; Jerzy Golik; Timothy P. Connolly; Thomas W. Hudyma; Srini Venkatesh; Mandar V. Dali; Shin-Hong Kang; Nancy P. Barbour; Ravi Tejwani; Sailesh A. Varia; Jay O. Knipe; Ming Zheng; Marina Mathew; Kathy Mosure; Junius M. Clark; Lucinda Lamb; Ivette Medin; Qi Gao; Stella Huang; Chung-Pin Chen; Joanne J. Bronson


Archive | 2001

Process for water soluble azole compounds

Chung-Pin Chen; Timothy P. Connolly; Laxma Reddy Kolla; John D. Matiskella; Richard H. Mueller; Yadagiri Pendri; Dejah T. Petsch


Archive | 2001

Improved process for water soluble azole compounds

Chung-Pin Chen; Timothy P. Connolly; Laxima Reddy Kolla; John D. Matiskella; Richard H. Mueller; Dejah T. Petsch; Yadagiri Rendri


Archive | 2003

Process for preparing the antiviral agent [1s-(1.alpha., 3.alpha., 4.beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecycloppentyl]-6h-purin-6-one

Yadagiri Pendri; Chung-Pin Chen; Sumil S. Patel; Jeffrey M. Evans; Jing Liang; David R. Kronenthal; Gerald L. Powers; Siva Josyula Prasad; Jeffrey T. Bien; Zhongping Shi; Ramesh N. Patel; Yeung Y. Chan; Sushil K. Rijhwani; Ambarish K. Singh; Shaopeng Wang; Milan Stojanovic; Richard Polniaszek; Charles Lewis; John K. Thottathil; Dhileepkumar Krishnamurty; Maotang X. Zhou; Purushotham Vemishetti


Archive | 2001

Verbessertes verfahren für wasserlösliche azolverbindungen

Chung-Pin Chen; Timothy P. Connolly; Laxima Reddy Kolla; John D. Matiskella; Richard H. Mueller; Dejah T. Petsch; Yadagiri Rendri


Archive | 2001

Promedicaments de composes d'azole, solubles dans l'eau

Chung-Pin Chen; Jerzy Golik; Thomas W. Hudyma; John D. Matiskella; Yasutsugu Ueda


Archive | 2001

Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs Improved process for the production of water-soluble o-phosphonooxymethyl-prodrugs

Chung-Pin Chen; Timothy P. Connolly; Reddy Laxma Rocky Hill Kolla; D Matiskella; H Mueller; Yadagiri Pendri; T Petsch


Archive | 2001

Wasserlösliche wirkstoffvorstufen von azolverbindungen Water-soluble drug precursors of azole compounds

Chung-Pin Chen; Jerzy Golik; W. Thomas Hudyma; D. John Matiskella; Yasutsugu Ueda


Archive | 2001

Procedimiento mejorado para la preparacion de profarmacos de o-fosfonoximetilo solubles en agua.

Chung-Pin Chen; Timothy P. Connolly; Laxma Reddy Kolla; John D. Matiskella; Richard H. Mueller; Yadagiri Pendri; Dejah T. Petsch

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