Cigdem Yolacan

Synthesis of New Pyrazolothiazole Derivatives from 4-Thiazolidinones

The synthesis of new 2,3,5,6-aryl substituted tetrahydro-2H-pyrazolo[3,4-d]- thiazoles 4a-j as potential biologically active compounds by the cyclocondensation of phenyl hydrazine with new 5-arylidene derivatives 2a-j of 2,3-disubstituted-1,3- thiazolidin-4-ones 1a-e is reported.

Epibatidine Alkaloid Chemistry: 5. Domino-Heck Reactions of Azabicyclic and Tricyclic Systems †

Palladium-catalyzed hydroarylations and additional domino reactions of aza-bicyclic and tricyclic norbornene derivatives were investigated and a series of new epibatidine analogues were synthesized.

Clauson Kaas Pyrrole Synthesis Catalyzed by Acidic Ionic Liquid under Microwave Irradiation

A new procedure to synthesize the N-substituted pyrrole derivatives by Clauson Kaas reaction catalyzed by acidic ionic liquid under microwave irradiation was developed. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.

Sulfur-nitrogen heterocycles from the condensation of pyrazolones and 2-iminothiazolidin-4-ones with phenyl isothiocyanate

The condensation of 2-pyrazolin-5-ones with phenyl isothiocyanate, followed by reaction of the resulting thiolate ions with chloroacetyl chloride, phenacyl bromide, oxalyl chloride, 1,4-dibromo-2,3-butanedione and ethyl chloroformate, resulted in cyclisation to S,N-heterocycles in all cases. 2-Iminothiazolidin-4-ones, with phenyl isothiocyanate and then chloroacetyl chloride or phenacyl bromide, similarly formed 2,4′-bi(thiazolidine)-derived products.

New and effective proline-based catalysts for asymmetric aldol reaction in water

ABSTRACT New proline diamide organocatalysts with Pro-Phe peptide bonds were synthesized and their catalytic activities in asymmetric direct aldol reactions of aliphatic ketones with aromatic aldehydes were investigated. Catalyst 6a showed good enantioselectivity at 0 °C in the presence of p-nitrobenzoic acid as cocatalyst in water. GRAPHICAL ABSTRACT

Domino-Heck Type Reactions of N-Benzoyl-2-Azabicyclo [2.2.1]Hept-5-ene-3-one

The coupling of 2-azabicyclo[2.2.1]hept-5-en-3-one and trimethylsilylacetylene or phenylacetylene under Domino Heck conditions gives compounds 2a c and 4a c in moderate yields and cyclopentene derivatives, 3a c in low yields. The procedure can be of use for the synthesis of alkynyl bicyclic lactams.

Convenient Route to Quinoline-Tetrahydroquinolines from Quinoline-Carboxaldehydes

Quinoline and tetrahydroquinoline structures are essential feature of many natural products. These heterocycles play a key role in heterocyclic and medicinal chemistry. Their synthesis by various methodologies has been published extensively1–3. However, in comparison to these systems, general synthetic methods of the preparation of diversely linked bisquinolines have been less developed. On the other hand, several N,N-(bisquinolin-4yl)(hetero)alkanediamines may be useful agents against chloroquineresistant malaria4–6. As a part of our research program on the chemistry of homoallylamines containing a (hetero)aromatic ring towards the synthesis of bioactive N-heterocycles7,8, we are pursuing investigations on the synthesis of 1,2,3,4-tetrahydroquinolines containing quinoline nucleus. In the present paper, we report a simply and efficient two step synthesis of 2-(8’quinolinyl)- and 2-(2’-quinolinyl)-1,2,3,4-tetrahydroquinolines using 6-exotrig process where allyl group of accessible 4-N-arylamino-4-quinolinyl-1butenes acts as an internal electrophilic C3 synthon8,9. The proposed route is based on our experience in the construction of diverse heterocycles containing nitrogen via cationic intramolecular cyclisation reactions of similar N-phenyl substituted amino-l -butenes (homoallylamines) that are very versatile starting materials, possessing an π-electron rich aromatic ring and an ally! fragment10–12.

The Biological Activities of New Heterocylic Compounds Containing Nitrogen and Sulphur

Oxadiazole derivatives which belong to an important group of heterocyclic compounds have been subject of extensive study in the recent past. Numerous reports have appeared which highlight their chemistry and. use1–3. Diverse biological activities such as antituberculostatic, antiinflamatory, analgesic, antipyretic, anticonvulsant, etc. have been found to be associated with oxadiazole derivatives4’5. Because of this reason we aimed to synthesize various 1,3,4-oxadiazole-2-thione derivatives to make remarkable contributions to this class of heterocyclic compounds. Here, we report the synthesis and characterization of some 5-alkyl substituted 1,3,4oxadiazole-2-thiones (3a-e) and 5-alkyl substituted 3-(2,4-dimethylphenyl)1,3,4-oxadiazole-2-thiones (4a-d) by using the synthetic procedure based on the ring closure reactions of appropriate acid hydrazides with carbon disulphide6. We also have synthesized some bis-Mannich bases by the reaction of 3a-e with benzaldehyde and benzidine.