Cintia Teles de Andrade
University of São Paulo
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Featured researches published by Cintia Teles de Andrade.
Photodiagnosis and Photodynamic Therapy | 2014
Dora Patricia Ramirez; Cristina Kurachi; Natalia Mayumi Inada; Lilian Tan Moriyama; Ana Gabriela Salvio; José Dirceu Vollet Filho; Layla Pires; Hilde H. Buzzá; Cintia Teles de Andrade; Clovis Greco; Vanderlei Salvador Bagnato
Non-melanoma skin cancer is the most prevalent cancer type in Brazil and worldwide. Photodynamic therapy (PDT) is a noninvasive technique with excellent cosmetic outcome and good curative results, when used for the initial stages of skin cancer. A Brazilian program was established to determine the efficacy of methyl aminolevulinate (MAL)-PDT, using Brazilian device and drug. The equipment is a dual device that combines the photodiagnosis, based on widefield fluorescence, and the treatment at 630nm. A protocol was defined for the treatment of basal cell carcinoma with 20% MAL cream application. The program also involves the training of the medical teams at different Brazilian regions, and with distinct facilities and previous PDT education. In this report we present the partial results of 27 centers with 366 treated BCC lesions in 294 patients. A complete response (CR) was observed in 76.5% (280/366). The better response was observed for superficial BCC, with CR 160 lesions (80.4%), when compared with nodular or pigmented BCC. Experienced centers presented CR of 85.8% and 90.6% for superficial and nodular BCC respectively. A high influence of the previous doctor experience on the CR values was observed, especially due to a better tumor selection.
Photodiagnosis and Photodynamic Therapy | 2014
Cintia Teles de Andrade; José Dirceu Vollet-Filho; Ana Gabriela Salvio; V. S. Bagnato; Cristina Kurachi
Non-melanoma skin cancer is the most common cancer lesion worldwide. In Brazil, it represents 95% of all skin cancer lesions, and 25% of all tumor types. Early diagnosis allows treatment at initial stages of the disease, improving patients prognosis. Thus, it is of great importance the development of techniques to aid diagnosis, such as marked fluorescence, which we propose here for early detection of skin cancer lesions. In this study, we use a photosensitive substance, aminolaevulinic acid (ALA), as biomarkers, and analyze its in situ fluorescence response to light excitation. The use of ALA as a biomarker precursor is interesting because it shows selectivity for protoporphyrin IX production/concentration in abnormal cells. Protoporphyrin IX shows high fluorescence yield when excited with UV-blue light. In this study, ALA solutions (at 5% and 10% concentrations) were applied to malignant (basal cell carcinoma) and potentially malignant skin lesions (actinic and seborrheic keratoses), aiming to investigate our ability in detecting and distinguishing them by using this technique. At regular time intervals (15, 30, 45 and 60min), fluorescence images were collected with a prototype system for widefield fluorescence imaging. ALA has provided a marked fluorescence that allowed significant discrimination of normal and tumor. Potentially malignant and benign lesions were all well-identified by their autofluorescence; photodynamic detection did not improve diagnostics. This technique also provided a better delineation of the lesion margins, which is very important for an effective treatment of malignant, potentially malignant and benign skin lesions.
SPIE Biophotonics South America | 2015
Clovis Grecco; Hilde H. Buzzá; Mirian D. Stringasci; Cintia Teles de Andrade; José Dirceu Vollet-Filho; Sebastião Pratavieira; Anderson Luis Zanchin; Aparecida M Tuboy; Vanderlei Salvador Bagnato
Photodynamic therapy (PDT) is a treatment modality that can be indicated for several cancer types and pre-cancer lesions. One of the main applications of PDT is the treatment of superficial skin lesions such as basal cell carcinoma, Bowen’s disease and actinic keratosis. Three elements are necessary in PDT, a photosensitizer (PS); light at specific wavelength to be absorbed by the PS, and molecular oxygen. A typical PS used for skin lesion is protoporphyrin IX (PpIX), which is an intrinsic PS; its production is stimulated by a pro-drug, such as 5-aminolevulinic acid (ALA). Before starting a treatment, it is very important to follow up the PpIX production (to ensure that enough PS was produced prior to a PDT application) and, during a PDT session, to monitor its photodegradation (as it is evidence of the photodynamic effect taking place). The aim of this paper is to present a unique device, LINCE (MMOptics - São Carlos, Brazil), that brings together two probes that can, respectively, allow for fluorescence imaging and work as a light source for PDT treatment. The fluorescence probe of the system is optically based on 400 nm LED (light emitting diodes) arrays that allow observing the fluorescence emission over 450 nm. The PDT illumination probe options are constituted of 630 nm LED arrays for small areas and, for large areas, of both 630 nm and 450 nm LED arrays. Joining both functions at the same device makes PDT treatment simpler, properly monitorable and, hence, more clinically feasible. LINCE has been used in almost 1000 PDT treatments of superficial skin lesions in Brazil, with 88.4% of clearance of superficial BCC.
Archive | 2013
Cintia Teles de Andrade; Natalia Mayumi Inada; Dora Patricia Ramirez; Vanderlei Salvador Bagnato; Cristina Kurachi
Treatments such as surgical excision, cryotherapy, topical application of imiquimod cream and 5-fluorouracil cream, and radiotherapy are commonly chosen based on the depth and exten‐ sion of the lesions. Limitations and side-effects of the conventional therapies motivate the development of other techniques. Photodynamic therapy (PDT) is presented as an alternative treatment for basal cell carcinoma (BCC).
Photodiagnosis and Photodynamic Therapy | 2018
Natalia Mayumi Inada; Hilde H. Buzzá; Fernanda Mansano Carbinatto; Kate Cristina Blanco; Cintia Teles de Andrade; José Dirceu Vollet-Filho; Vanderlei Salvador Bagnato; Ron R. Allison
Human papillomaviruses (HPV) are the most common sexually-transmitted virus, and carcinogenic HPV strains are reported to be responsible for virtually all cases of cervical cancer and its precursor, the cervical intraepithelial neoplasia (CIN). About 30% of the sexually active population are considered to be affected by HPV. Around 600 million people are estimated to be infected worldwide. Diseases related to HPV cause significant impact from both the personal welfare point of view and public healthcare perspective. This resource letter collects relevant information regarding HPV-induced lesions and discusses both diagnosis and treatment, with particular attention to optical techniques and the challenges involved to the implementation of those approaches.
Photodiagnosis and Photodynamic Therapy | 2017
José Dirceu Vollet Filho; Cintia Teles de Andrade; Hilde H. Buzzá; Kate Cristina Blanco; Fernanda Mansano Carbinatto; Vanderlei Salvador Bagnato; Ron R. Allison
Aktinic Keratosis is common and if left untreated may develop into life threatening squamous cell carcinoma. Therefore early intervention is the standard of care. While many treatments are available PDT continues to move to the for - front for this indication (Brito et al., 2016 [31]). Topical PS is commercially available that are able to reliably ablate these lesions. Innovative protocols including sunlight, large volume LED arrays and maneuvers to improve treatment parameters and cosmesis continue to make this a worldwide treatment of choice for AK.
Latin America Optics and Photonics Conference (2012), paper LT4A.4 | 2012
Natalia Mayumi Inada; Dora Patricia Ramirez; Lilian Tan Moriyama; Cintia Teles de Andrade; Clóvis Grecco; Ana Gabriela Salvio; Cristina Kurachi; Vanderlei Salvador Bagnato
Non melanoma skin cancer (NMSC) is the most frequent worldwide, and it is necessary the development of new technologies with successful results. We are presenting our National Program for the Photodynamic Therapy of NMSC.
Latin America Optics and Photonics Conference (2012), paper LT2A.19 | 2012
Cintia Teles de Andrade; José Dirceu Vollet-Filho; Ana Gabriela Salvio; Vanderlei Salvador Bagnato; Cristina Kurachi
In vitro and in vivo tests were performed to investigate marked fluorescence diagnosis of basal cell carcinoma. Results showed improved differentiation between normal and lesion tissues. Excitation light showed to be limiting factor for diagnosis.
Latin America Optics and Photonics Conference (2010), paper MB13 | 2010
Ruy Carvalho Mattosinho Castro Ferraz; Cintia Teles de Andrade; Carla Raquel Fontana; Emery C. Lins; Vanderlei Salvador Bagnato; Cristina Kurachi
In this study, the viability of chemiluminescence use a PDT light source was evaluated in the in vitro microbial reduction of Staphylococcus aureus.
Latin America Optics and Photonics Conference (2010), paper MB10 | 2010
Cintia Teles de Andrade; José Dirceu Vollet-Filho; Mardoqueu Martins da Costa; Natalia Mayumi Inada; Vanderlei Salvador Bagnato; Cristina Kurachi
This study investigates light propagation (UV-blue range) in a skin tissue phantom to characterize a LED cancer diagnosis device using a photosensitizer (protoporphyrin IX) as a biomarker.