Claire Leurent

Systems pharmacology modeling in 5HT4: Prediction and outcome of a clinical scopolamine impairment trial and further application to Alzheimer's disease pathology

then challenged orally with CWD infected brains. Tonsil and rectal biopsies plus blood, saliva, feces and urine were collected every three months post-infection until the 9 month; and every 45 days thereafter. Results: Two vaccinated animals produced low antibody titers, two intermediate titers and one high titers of IgA and IgG anti-PrP. Both groups produced high titers of IgA and IgG against Salmonella. Six months post-infection 5 out of 6 controls and 3 out of 5 vaccinated showed histologically prion structures in the tonsils. Ayear post-infection one of the vaccinated animals remained prion free, with all controls being infected. The negative animal has the highest titers of IgA in saliva and IgG systemic against PrP. Immunoglobulins purified from saliva, feces and serum of this vaccinated deer reacts to PrP. Conclusions: Oral immunization can be used to overcome tolerance to self-PrP protein and produce a mucosal IgA and systemic IgG response to normal and conformational modified PrP in large mammals. High antibody titers might be enough to prevent transmission or to retard progression of PrP infection. This approach may lead to an effective anti-prion vaccine.

LOW PREVALENCE OF AMYLOID POSITIVITY IN HEALTHY ELDERLY PARTICIPANTS OF A METHODOLOGY STUDY EVALUATING REMOTE TABLET-BASED COGNITIVE LEARNING

Conclusions Though a gold standard of amyloid burden was not available, results indicate that a hybrid qualitative visual / quantitative method can be used to obtain greater concordance between quantitative and visual results. Clinical studies using only visual or only SUVR information for eligibility decisions must understand the implications of potential differences between the visual and quantitative methodologies.