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Clare Octavia Kneen

Merck & Co.

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Publication

Featured researches published by Clare Octavia Kneen.

Bioorganic & Medicinal Chemistry Letters | 2009

Oxadiazolone bioisosteres of pregabalin and gabapentin.

David Juergen Wustrow; Thomas Richard Belliotti; Thomas Capiris; Clare Octavia Kneen; Justin Stephen Bryans; Mark J. Field; Dic Williams; Ayman El-Kattan; Lisa Buchholz; Jack J. Kinsora; Susan M. Lotarski; Mark G. Vartanian; Charles P. Taylor; Sean Donevan; Andrew John Thorpe; Jacob Bradley Schwarz

A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the alpha(2)-delta subunit of voltage-gated calcium channels. Oxadiazolone 9 derived from 2 achieved low brain uptake but was nevertheless active in models of osteoarthritis. The high clearance associated with compound 9 was postulated to be a consequence of efflux by OAT and/or OCT, and was attenuated on co-administration with cimetidine or probenecid.

Journal of Medicinal Chemistry | 1990

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor

John Saunders; Mark Cassidy; Stephen B. Freedman; Elizabeth A. Harley; Leslie L. Iversen; Clare Octavia Kneen; Angus Murray Macleod; Kevin John Merchant; Roger J. Snow; Raymond Baker

Journal of Medicinal Chemistry | 1998

Identification of Novel Ligands for the Gabapentin Binding Site on the α2δ Subunit of a Calcium Channel and Their Evaluation as Anticonvulsant Agents

Justin Stephen Bryans; Natasha Davies; Nicolas S. Gee; Visaka Udeni Karalliadde Dissanayake; Giles S. Ratcliffe; David Christopher Horwell; Clare Octavia Kneen; Andrew Morrell; Ryszard J. Oles; John O'Toole; Gemma M. Perkins; Lakhbir Singh; Nirmala Suman-Chauhan; Jacqueline A. O'Neill

Archive | 1998

1-substituted-1-aminomethyl-cycloalkane derivatives (= gabapentin analogues), their preparation and their use in the treatment of neurological disorders

Justin Stephen Bryans; Thomas Capiris; David Christopher Horwell; Clare Octavia Kneen; David Juergen Wustrow

Archive | 1997

Substituted gamma aminobutyric acids as pharmaceutical agents

Justin Stephen Bryans; David Christopher Horwell; Clare Octavia Kneen; David Juergen Wustrow; Andrew John Thorpe

Archive | 2000

Cyclic amino acids as pharmaceutical agents

David Christopher Horwell; Justin Stephen Bryans; Clare Octavia Kneen; Giles S. Ratcliffe

Archive | 1997

Novel substituted cyclic amino acids as pharmaceutical agents

David Christopher Horwell; Justin Stephen Bryans; Clare Octavia Kneen; Andrew Morrell; Giles S. Ratcliffe; Johannes Hartenstein

Archive | 1997

Bridged cyclic amino acids as pharmaceutical agents

David Christopher Horwell; Justin Stephen Bryans; Clare Octavia Kneen; Andrew Morrell; Giles S. Ratcliffe

Archive | 1998

Novel amines as pharmaceutical agents

Thomas Richard Belliotti; Justin Stephen Bryans; Thomas Capiris; David Christopher Horwell; Clare Octavia Kneen; David Juergen Wustrow

Archive | 1997

Substituted cyclic amino acids as pharmaceutical agents

David Christopher Horwell; Justin Stephen Bryans; Clare Octavia Kneen; Andrew Morrell; Giles S. Ratcliffe; Johannes Hartenstein

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Collaboration

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Justin Stephen Bryans

University of Cambridge

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David Juergen Wustrow

Pfizer

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Thomas Capiris

Pfizer

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Raymond Baker

Merck

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Thomas Richard Belliotti

Pfizer

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Andrew John Thorpe

Pfizer

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Christopher John Swain

University of Leicester

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Christopher John Swain

University of Leicester

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Ayman El-Kattan

Pfizer

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Charles P. Taylor

Pfizer

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