Thomas Richard Belliotti
Pfizer
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Publication
Featured researches published by Thomas Richard Belliotti.
Bioorganic & Medicinal Chemistry Letters | 2009
David Juergen Wustrow; Thomas Richard Belliotti; Thomas Capiris; Clare Octavia Kneen; Justin Stephen Bryans; Mark J. Field; Dic Williams; Ayman El-Kattan; Lisa Buchholz; Jack J. Kinsora; Susan M. Lotarski; Mark G. Vartanian; Charles P. Taylor; Sean Donevan; Andrew John Thorpe; Jacob Bradley Schwarz
A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the alpha(2)-delta subunit of voltage-gated calcium channels. Oxadiazolone 9 derived from 2 achieved low brain uptake but was nevertheless active in models of osteoarthritis. The high clearance associated with compound 9 was postulated to be a consequence of efflux by OAT and/or OCT, and was attenuated on co-administration with cimetidine or probenecid.
Journal of Medicinal Chemistry | 2005
Thomas Richard Belliotti; Thomas Capiris; I. Victor Ekhato; Jack J. Kinsora; Mark J. Field; Thomas G. Heffner; Leonard T. Meltzer; Jacob Bradley Schwarz; Charles P. Taylor; Andrew John Thorpe; Mark G. Vartanian; Lawrence D. Wise; Ti Zhi-Su; Mark L. Weber; David Juergen Wustrow
Archive | 2000
Thomas Richard Belliotti; Justin Stephen Bryans; Ihoezo Victor Ekhato; Augustine Tobi Osuma; Robert Michael Schelkun; Jacob Bradley Schwarz; Andrew John Thorpe; Lawrence D. Wise; David Juergen Wustrow; Po-Wai Yuen
Archive | 1998
Thomas Richard Belliotti; Justin Stephen Bryans; Thomas Capiris; David Christopher Horwell; Clare Octavia Kneen; David Juergen Wustrow
Archive | 1999
Thomas Richard Belliotti; David Juergen Wustrow
Journal of Medicinal Chemistry | 1998
David Juergen Wustrow; Thomas Richard Belliotti; Shelly Ann Glase; Suzanne Ross Kesten; Don Johnson; Norman L. Colbry; Ronald Rubin; Anthony C. Blackburn; Hyacinth Akunne; Ann E. Corbin; M. Duff Davis; Lynn M. Georgic; Steven Z. Whetzel; Kim Zoski; Thomas G. Heffner; Thomas A. Pugsley; Lawrence D. Wise
Journal of Medicinal Chemistry | 1999
Thomas Richard Belliotti; David Juergen Wustrow; Wouter A. Brink; Kim Zoski; Yu-Hsin Shih; Steven Z. Whetzel; Lynn M. Georgic; Ann E. Corbin; Hyacinth Akunne; Thomas G. Heffner; Thomas A. Pugsley; Lawrence D. Wise
Bioorganic & Medicinal Chemistry Letters | 2007
Daniel D. Holsworth; Mehran Jalaie; Thomas Richard Belliotti; Cuiman Cai; Wendy Collard; Suzie Ferreira; Noel A. Powell; Michael Andrew Stier; Erli Zhang; Pat McConnell; Igor Mochalkin; Michael J. Ryan; John W. Bryant; Tingsheng Li; Aparna Kasani; Rajendra Subedi; Samarendra N. Maiti; Jeremy J. Edmunds
Archive | 2000
Thomas Richard Belliotti; Andrew John Thorpe; David Juergen Wustrow
Archive | 1997
Thomas Richard Belliotti; Lawrence D. Wise; David Juergen Wustrow
